Minimally Invasive Surgery (MIS) has been limited from its inception by insufficient haptic feedback to surgeons. To address this, various force sensing methods have been developed that can provide information about tool–tissue interaction forces. However, the results have been unreliable in most of these studies since there are many sources of error and uncertainty in the force acquisition method. Furthermore, none of the force sensing devices described in the literature can be fully cleaned or sterilized for use in surgery. To address this, a sterilizable needle-driver type grasper is presented in this paper that incorporates fiber Bragg gratings to measure axial and grasping forces. The results of its performance evaluation show that the 2-degrees of freedom grasper is capable of measuring grasping and axial forces with an accuracy of 0.27 N and 0.3 N, respectively. Integration of this device into a needle driver instrument will result in a sterilizable instrument capable of measuring tool– tissue interaction forces during MIS.

Chronic Obstructive Pulmonary Disease (COPD) is a life-threatening lung disease and a major cause of morbidity and mortality worldwide. Although a curative therapy has yet to be found, permanent monitoring of biomarkers that reflect the disease progression plays a pivotal role for the effective management of COPD. The accurate examination of respiratory tract fluids like saliva is a promising approach for staging disease and predicting its upcoming exacerbations in a Point-of-Care (PoC) environment. However, the concurrent consideration of patients' demographic and medical parameters is necessary for achieving accurate outcomes. Therefore, Machine Learning (ML) tools can play an important role for analyzing patient data and providing comprehensive results for the recognition of COPD in a PoC setting. As a result, the objective of this research work was to implement ML tools on data acquired from characterizing saliva samples of COPD patients and healthy controls as well as their demographic information for PoC recognition of the disease. For this purpose, a permittivity biosensor was used to characterize dielectric properties of saliva samples and, subsequently, ML tools were applied on the acquired data for classification. The XGBoost gradient boosting algorithm provided a high classification accuracy and sensitivity of 91.25% and 100%, respectively, making it a promising model for COPD evaluation. Integration of this model on a neuromorphic chip, in the future, will enable the real-time assessment of COPD in PoC, with low cost, low energy consumption, and high patient privacy. In addition, constant monitoring of COPD in a near-patient setup will enable the better management of the disease exacerbations.

This paper presents a dielectrophoretic system for the immobilization and separation of live and dead cells. Dielectrophoresis (DEP) is a promising and efficient investigation technique for the development of novel lab-on-a-chip devices, which characterizes cells or particles based on their intrinsic and physical properties. Using this method, specific cells can be isolated from their medium carrier or the mixture of cell suspensions (e.g., separation of viable cells from non-viable cells). Main advantages of this method, which makes it favorable for disease (blood) analysis and diagnostic applications are, the preservation of the cell properties during measurements, label-free cell identification, and low set up cost. In this study, we validated the capability of complementary metal-oxide-semiconductor (CMOS) integrated microfluidic devices for the manipulation and characterization of live and dead yeast cells using dielectrophoretic forces. This approach successfully trapped live yeast cells and purified them from dead cells. Numerical simulations based on a two-layer model for yeast cells flowing in the channel were used to predict the trajectories of the cells with respect to their dielectric properties, varying excitation voltage, and frequency.

In spite of the remarkable benefits that minimally invasive surgery provides for patients, the absence of force feedback is still a significant disadvantage. Several studies have been performed to address this issue; however, an accurate sterilizable force sensing technology for measuring axial and grasping forces is still missing. In this work, an innovative partial grasper has been designed and developed for a laparoscopic needle driver that can measure axial and grasping force information at the grasper tip. Fiber Bragg Grating sensors are used in this work because of their sterilizability and high sensitivity. Accuracies of 0.19 N and 0.26 N were achieved for the grasping and axial sensors respectively.

Chronic Obstructive Pulmonary Disease (COPD) is a life-threatening lung disease, affecting millions of people worldwide. Implementation of Machine Learning (ML) techniques is crucial for the effective management of COPD in home-care environments. However, shortcomings of cloud-based ML tools in terms of data safety and energy efficiency limit their integration with low-power medical devices. To address this, energy efficient neuromorphic platforms can be used for the hardware-based implementation of ML methods. Therefore, a memristive neuromorphic platform is presented in this paper for the on-chip recognition of saliva samples of COPD patients and healthy controls. Results of its performance evaluations showed that the digital neuromorphic chip is capable of recognizing unseen COPD samples with accuracy and sensitivity values of 89% and 86%, respectively. Integration of this technology into personalized healthcare devices will enable the better management of chronic diseases such as COPD.