To Development and Evaluation of Aceclofenac Swellable Matrix Tablets Utilizing Okra (Abelmoschus Esculentus) and Hibiscus Leaf (Hibiscus Rosa-Sinensis) Natural Polymer Mucilage as Release Modifier.This study investigates the development of sustained-release Aceclofenac tablets using natural polymers, Okra Gum and Hibiscus Leaf Mucilage, to enhance drug efficacy, reduce dosing frequency, and minimize adverse effects in the treatment of inflammation and pain.: Sustained-release NSAID formulations using natural polymers like Okra Gum and Hibiscus Leaf Mucilage enhance drug efficacy, patient adherence, and safety by reducing dosing frequency and adverse effects.Non-steroidal anti-inflammatory drugs (NSAIDs), like Aceclofenac, are commonly prescribed for managing inflammation and pain associated with various conditions such as arthritis, musculoskeletal disorders, and post-operative recovery. Despite their effectiveness, traditional NSAIDs often exhibit rapid-release kinetics, necessitating frequent dosing intervals to maintain therapeutic efficacy. However, frequent dosing increases the risk of adverse effects such as gastrointestinal complications, renal impairment, and cardiovascular events. To address these challenges, sustained-release formulations have been developed to prolong drug action and reduce dosing frequency. Natural polymers, such as Okra Gum and Hibiscus Leaf Mucilage, have emerged as promising excipients for sustained drug delivery systems. These natural polymers offer several advantages, including biocompatibility, biodegradability, and the ability to modulate drug release kinetics. By incorporating Okra Gum and Hibiscus Leaf Mucilage into pharmaceutical formulations can improve patient adherence and therapeutic effectiveness while minimizing adverse effects.Fourier Transform Infrared analysis conducted as part of this study demonstrated no chemical interaction between Aceclofenac and the natural polymers, confirming their compatibility for formulation purposes. The formulated tablets met pharmacopoeial specifications for physicochemical properties, ensuring quality and consistency in manufacturing. The optimized formulation exhibited prolonged drug release lasting up to 12 hours, with release kinetics inversely proportional to polymer concentration. Stability studies conducted over a specified period indicated no significant changes in tablet attributes, affirming the robustness of the formulation.The findings of this study confirm the suitability of Okra Gum and Hibiscus Leaf Mucilage as effective release modifiers for Aceclofenac, offering potential benefits for sustained drug delivery in inflammation therapy. By providing valuable insights into the development of improved drug delivery systems using natural polymers, this research contributes to enhanced patient care and treatment outcomes in inflammatory conditions. Further exploration and optimization of natural polymer-based formulations hold promise for advancing drug delivery technologies and improving patient outcomes in clinical practice.

Background: Pneumonia is a common respiratory infection affecting millions of people worldwide and often leads to serious complications such as pulmonary fibrosis – a progressive disorder recognized by persistent scarring, alveolar thickening, impaired gas exchange, and reduced lung capacity. The pathogenesis of pulmonary fibrosis remains complex and poorly understood. A hallmark feature is the buildup of extracellular matrix disrupting the normal architecture and function of the lung parenchyma, ultimately causing irreversible lung damage. At present, there is no known remedy for pulmonary fibrosis, and the existing treatments are often limited in efficacy and associated with adverse effects. This underscores the urgent need to identify novel molecular targets and therapeutic approaches for this debilitating condition. Aim: This review summarizes recent advances in understanding the pharmacotherapeutic potential of microRNAs (miRNAs) in reducing fibrosis associated with pneumonia and pulmonary fibrosis. It highlights the signaling mechanisms through which miRNAs regulate gene expression, as well as their role in maintaining lung development and homeostasis. The review also identifies the specific miRNAs with antifibrotic effects as demonstrated in experimental models and clinical settings. Finally, it discusses the key challenges in developing miRNA-based therapies, including delivery strategies and off-target effects. Methods: The study entailed a thorough literature review on antifibrotic effect of mi-RNA in pneumonia and lung fibrosis, conducted through the electronic searches on Google, Google Scholar, and PubMed databases. Results: In his study we provide a recent finding on antifibrotic activity of miRNA in pulmonary complications. Moreover, the evidences from animal and clinical researches are also discussed. This may further help scholars, practitioners, and legislators who are interested to do the research on mi-RNA therapies in clinical practice. Conclusion: In conclusion, miRNA-based diagnostics and therapies represent a promising frontier for the management of pneumonia and pulmonary fibrosis. Further research is warranted to deepen our understanding of miRNA mechanisms in the therapeutic context. Relevance for patients: Advances in therapies for pneumonia and pulmonary fibrosis can enhance treatment efficacy, aiding in the mitigation and treatment of the disease.

The human body is influenced by different factors, like genetical, physiological, and external factors. It is necessary to mark that the constituents of the intestinal microbes significantly affects health, which involved the harmful microorganisms in a variety of practices that affect physical functions by promoting or reducing their existence. The GI-microbiome, a complex community of trillions of microbes that live in the GIT, contributes the principal role in digestive and overall health. This review examines the complex connections between the GI-microbes and multiple areas of human health, digestion, nutrient absorption, immune support, and mental well-being. This chapter also demonstrates the effects of microbial dysbiosis in host health, and the possibility of dietary intervention to regulate the intestinal microbes for the purpose of being probiotics, prebiotics, and intestinal microbes. Additionally, the complexities of the GI-microbiome in understanding of its important role in maintaining health and preventing disease are also discussed.