Biomass burning in the Amazon region, especially during the dry season, generates aerosol dispersion events across the southern part of the continent, with impacts observable thousands of kilometers from the emission source. This study presents a long-range aerosol transport case from September 2024, in which smoke aerosols from forest fires in the central Amazon reached southeastern and southern Brazil, affecting the air quality in distant areas such as São Paulo and São Martinho. The event was simulated using the Weather Research and Forecasting model with Chemistry (WRF-Chem), configured with the MOZCART chemical mechanism, combined with MERRA-2 reanalysis data and by using the 3BEM biomass burning emission inventory. Satellite datasets from MODIS and MERRA-2 reanalysis were used to evaluate the model’s performance. The results indicate that the South American Low-Level Jet (SALLJ) played a key role in transporting carbonaceous aerosols over long distances. The model successfully captured the spatial and temporal evolution of the aerosol plume and its impacts, although it tended to underestimate aerosol optical depth (AOD) values compared with satellite observations. This study highlights the WRF-Chem’s capability to simulate extreme smoke transport events in South America and supports its potential application in forecasting and air quality assessments.