Quercus laurina is an oak species used orally in Mexican folk medicine. However, its toxicological profile has not yet been evaluated, which makes it difficult to determine safe doses for traditional preparations. This study, for the first time, evaluates the acute toxicity of an ethanolic extract of Q. laurina bark (QLBE) in Wistar rats in accordance with OECD guideline 423, and it explores the impact of QLBE on mitochondrial bioenergetics and glycolytic capacity in primary hepatocytes to determine whether the extract alters cellular energy metabolism. QLBE at 2000 mg/kg elicited death and tremors, and a dose‐dependent hepatic injury, in addition to histopathological changes in the kidney, brain, lung, and heart. QLBE caused a significant reduction in the basal, ATP‐linked, spare, and maximal mitochondrial respiratory capacities of hepatocytes, and it decreased glycolytic capacity after 2 and 24 h of exposure. These findings indicate that QLBE disrupts mitochondrial bioenergetics and glycolytic activity in hepatocytes, alterations that may be associated with the observed liver toxicity. HPLC and GC–MS analyses identified myo‐inositol, quininic acid, and ellagic acid as the primary metabolites of QLBE. The results demonstrated the toxic potential of QLBE, thereby discouraging its unregulated use in traditional remedies in Mexican folk medicine.

Background: Invasive breast cancer (IBC) is the most prevalent neoplasm and the leading cause of death in women worldwide. Young women under 40 years of age, despite their low incidence, have different clinical-pathological characteristics than older women, giving them a worse prognostic profile. Objective: To determine the association between risk factors associated with MIC in young women in Michoacan. Methods: descriptive, observational, retrospective and cross-sectional study that included 1178 patients < 40 years of age with MIC diagnosed in the period 2015-2022 in a second-level hospital of the IMSS in Michoacán. Sample size at convenience, with database registration, with the use of means, standard deviation, chi-square and Student's t-test, p ≤ 0.05 as an indicator of significance. Registration Number: R-2022-1602-025. Results: of 1178 cases, 12.1% were in young women, who had an increased risk of tumors > 2 cm (p = 0.02, 1.062–2.058), ER–/RP– (p = 0.0067, 1.158–2.501) and triple negative (p = 0.0006; 1.377–5.563). Obesity III was associated with larger tumors (P = 0.0028, 1.051–3.518), advanced TNM stages (P = 0.0445), and greater tissue involvement (T3-T4, P = 0.0301). Conclusions: Breast cancer in young women in Michoacan showed worse prognostic clinical profiles compared to older women.