Geological Carbon Sequestration (GCS) plays a crucial role in addressing climate change, particularly in oil and gas development. Understanding the reaction of supercritical CO₂ under in situ conditions and its effects on minerals is essential for advancing GCS technology. This study investigates the reaction mechanisms of feldspar (potassium and sodium feldspar) and clay minerals (chlorite, illite, montmorillonite, kaolinite) in CO₂ environments. The impacts on mineral crystal structures, morphologies, and elemental compositions were analyzed using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), and ion concentration measurements (ICP-OES and ICP-MS). The results show that feldspar minerals exhibit lower reaction rates, with sodium feldspar dissolving faster than potassium feldspar, due to the higher solubility of sodium ions in acidic conditions. Chlorite showed significant crystal structure damage after 30 days, while montmorillonite underwent both dissolution and precipitation, influenced by interlayer cation dissociation. Kaolinite exhibited minimal reaction, primarily showing localized dissolution. Additionally, the formation of siderite (FeCO₃) was observed as Fe²⁺ substituted for Ca²⁺ in CaCO₃, highlighting the role of iron-bearing carbonates in CO₂ interactions. The study provides insights into the factors influencing mineral reactivity, including mineral structure, ion exchange capacity, and solubility, and suggests that chlorite, montmorillonite, and illite are more reactive under reservoir conditions, while kaolinite shows higher resistance to CO₂-induced reactions. These findings offer valuable data for optimizing GCS technologies and predicting long-term sequestration outcomes.