Age-related cognitive and brain declines can result in functional deterioration in many cognitive domains, dependency, and dementia. A major goal of aging research is to investigate methods that help to maintain brain health, cognition, independent living and wellbeing in older adults. This randomized controlled study investigated the effects of 20 1-hr non-action video game training sessions with games selected from a commercially available package (Lumosity) on a series of age-declined cognitive functions and subjective wellbeing. Two groups of healthy older adults participated in the study, the experimental group who received the training and the control group who attended three meetings with the research team along the study. Groups were similar at baseline on demographics, vocabulary, global cognition, and depression status. All participants were assessed individually before and after the intervention, or a similar period of time, using neuropsychological tests and laboratory tasks to investigate possible transfer effects. The results showed significant improvements in the trained group, and no variation in the control group, in processing speed (choice reaction time), attention (reduction of distraction and increase of alertness), immediate and delayed visual recognition memory, as well as a trend to improve in Affection and Assertivity, two dimensions of the Wellbeing Scale. Visuospatial working memory (WM) and executive control (shifting strategy) did not improve. Overall, the current results support the idea that training healthy older adults with non-action video games will enhance some cognitive abilities but not others. Trial Registration: ClinicalTrials.gov identifier NCT02007616http://clinicaltrials.gov/show/NCT02007616

Video game training with older adults potentially enhances aspects of cognition that decline with aging and could therefore offer a promising training approach. Although, previous published studies suggest that training can produce transfer, many of them have certain shortcomings. This randomized controlled trial (RCT; Clinicaltrials.gov ID: NCT02796508) tried to overcome some of these limitations by incorporating an active control group and the assessment of motivation and expectations. Seventy-five older volunteers were randomly assigned to the experimental group trained for 16 sessions with non-action video games from Lumosity, a commercial platform (http://www.lumosity.com/) or to an active control group trained for the same number of sessions with simulation strategy games. The final sample included 55 older adults (30 in the experimental group and 25 in the active control group). Participants were tested individually before and after training to assess working memory (WM) and selective attention and also reported their perceived improvement, motivation and engagement. The results showed improved performance across the training sessions. The main results were: (1) the experimental group did not show greater improvements in measures of selective attention and working memory than the active control group (the opposite occurred in the oddball task); (2) a marginal training effect was observed for the N-back task, but not for the Stroop task while both groups improved in the Corsi Blocks task. Based on these results, one can conclude that training with non-action games provide modest benefits for untrained tasks. The effect is not specific for that kind of training as a similar effect was observed for strategy video games. Groups did not differ in motivation, engagement or expectations.

This randomized controlled study (ClinicalTrials.gov NCT02007616) investigated the maintenance of training effects of 20 1-hr non-action video game training sessions with selected games from a commercial package on several age-declining cognitive functions and subjective wellbeing after a 3-month no-contact period. Two groups of cognitively normal older adults participated in both the post-training (posttest) and the present follow-up study, the experimental group who received training and the control group who attended several meetings with the research team during the study but did not receive training. Groups were similar at baseline on demographics, vocabulary, global cognition, and depression status. Significant improvements in the trained group, and no variation in the control group had been previously found at posttest, in processing speed, attention and visual recognition memory, as well as in two dimensions of subjective wellbeing. In the current study, improvement from baseline to 3 months follow-up was found only in wellbeing (Affection and Assertivity dimensions) in the trained group whereas there was no change in the control group. Previous significant improvements in processing speed, attention and spatial memory become nonsignificant after the 3-month interval. Training older adults with non-action video games enhanced aspects of cognition just after training but this effect disappeared after a 3-month no-contact follow-up period. Cognitive plasticity can be induced in older adults by training, but to maintain the benefits periodic boosting sessions would be necessary.

The decays ${\chi }_{c1}\to J/\psi {\mu }^{+}{\mu }^{-}$ and ${\chi }_{c2}\to J/\psi {\mu }^{+}{\mu }^{-}$ are observed and used to study the resonance parameters of the ${\chi }_{c1}$ and ${\chi }_{c2}$ mesons. The masses of these states are measured to be $m({\chi }_{c1})=3510.71\pm 0.04(\mathrm{stat})\pm 0.09(\mathrm{syst})\mathrm{MeV}$ and $m({\chi }_{c2})=3556.10\pm 0.06(\mathrm{stat})\pm 0.11(\mathrm{syst})\mathrm{MeV}$, where the knowledge of the momentum scale for charged particles dominates the systematic uncertainty. The momentum-scale uncertainties largely cancel in the mass difference $m({\chi }_{c2})-m({\chi }_{c1})=45.39\pm 0.07(\mathrm{stat})\pm 0.03(\mathrm{syst})\mathrm{MeV}$. The natural width of the ${\chi }_{c2}$ meson is measured to be $\mathrm{\Gamma }({\chi }_{c2})=2.10\pm 0.20(\mathrm{stat})\pm 0.02(\mathrm{syst})\mathrm{MeV}$. These results are in good agreement with and have comparable precision to the current world averages.

Measurements of CP observables in B ⁰ → DK ^∗0 decays are presented, where D represents a superposition of D ⁰ and $$ {\overline{D}}^0 $$ D ¯ 0 states. The D meson is reconstructed in the two-body final states K ⁺ π ⁻, π ⁺ K ⁻, K ⁺ K ⁻ and π ⁺ π ⁻, and, for the first time, in the fourbody final states K ⁺ π ⁻ π ⁺ π ⁻, π ⁺ K ⁻ π ⁺ π ⁻ and π ⁺π⁻π⁺π⁻. The analysis uses a sample of neutral B mesons produced in proton-proton collisions, corresponding to an integrated luminosity of 1.0, 2.0 and 1.8 fb⁻¹ collected with the LHCb detector at centre-of-mass energies of $$ \sqrt{s}=7,8 $$ s = 7 , 8 and 13 TeV, respectively. First observations of the decays B ⁰ → D(π ⁺ K ⁻)K ^∗0 and B ⁰ → D(π ⁺ π ⁻ π ⁺ π ⁻)K ^∗0 are obtained. The measured observables are interpreted in terms of the CP -violating weak phase γ.