Tomasz Dariusz Fajferek

Mr. Tomasz Dariusz Fajferek

orcid

Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
5 December 2025 in Applied Sciences
Verified
Journal Article
Open access
PDF file
TFTomasz Dariusz Fajferek
Tomasz Dariusz Fajferek
AJAleksander Joniec
Aleksander Joniec
SKSeweryn Kaczara
Seweryn Kaczara
EMEmma Mażul-Kulesza
Emma Mażul-Kulesza
JMJedrzej Mikolajczyk
Jedrzej Mikolajczyk
BPBarbara Zofia Pietrzyk
Barbara Zofia Pietrzyk
(1) Background: Surgical site infections (SSIs) pose a significant clinical challenge, with early detection hindered by the overlap between physiological postoperative inflammation and incipient infection. Continuous wound temperature monitoring offers a promising, non-invasive method to identify subtle thermal deviations that precede overt clinical signs. This review synthesizes current evidence on the utility of temperature monitoring as an early predictor of SSI and evaluates its clinical applications. (2) Methods: A narrative literature review was conducted using PubMed and Embase for English-language studies published between 2015 and 2025. Following PRISMA principles, eligible studies were selected that examined continuous or repeated local wound temperature measurements in adult postoperative patients and their association with a clinical diagnosis of SSI. (3) Results: Six studies met the inclusion criteria. Key findings indicate that infected wounds may paradoxically exhibit lower temperatures “cold spots” than non-infected wounds in the early postoperative period. Dynamic indicators, particularly the temperature difference (ΔT) between the wound and adjacent skin and the temperature trajectory over time, proved more predictive than single, isolated measurements. Confounding factors such as patient adiposity were noted to influence thermal signatures. (4) Conclusions: Wound temperature monitoring is a valuable strategy for the early risk stratification of SSI. The analysis of thermal trends and dynamic parameters holds greater diagnostic significance than single readings. Integration with other biomarkers may further enhance specificity, but the development of standardized measurement protocols is essential for reliable clinical implementation and improved postoperative outcomes.

Verified
Journal Article
Open access
PDF file
BPBarbara Zofia Pietrzyk
Barbara Zofia Pietrzyk
JMJedrzej Mikolajczyk
Jedrzej Mikolajczyk
AJAleksander Joniec
Aleksander Joniec
TFTomasz Dariusz Fajferek
Tomasz Dariusz Fajferek
SKSeweryn Kaczara
Seweryn Kaczara
Controlled local hyperthermia supports postoperative wound healing in liver surgery by stimulating metabolism, angiogenesis, and immune responses through the induction of heat shock proteins (HSPs) and modulation of Damage-Associated Molecular Patterns (DAMPs). This study evaluates the impact of thermal modulation on immune processes during abdominal wound repair, specifically analyzing the role of HSPs and immune activation pathways. A narrative review of the literature from 2010 to 2025 was conducted to summarize molecular mechanisms regarding temperature, HSP activation, cytokine expression, and DAMPs, excluding studies conducted solely in animal models. The results indicate that precise local hyperthermia in postoperative abdominal wounds activates HSPs as well as inflammasome and Toll-like receptor (TLR) pathways, modulating immune and cytokine responses depending on the type and depth of tissue injury. Consequently, such thermoimmunomodulation stabilizes immune cell functions, optimizes the balance between inflammation and regeneration, and minimizes the risk of postoperative complications to support effective wound healing.

27 February 2026 in Applied Sciences
Verified
Journal Article
Open access
PDF file
AJAleksander Joniec
Aleksander Joniec
JMJedrzej Mikolajczyk
Jedrzej Mikolajczyk
SKSeweryn Kaczara
Seweryn Kaczara
EMEmma Mażul-Kulesza
Emma Mażul-Kulesza
TFTomasz Dariusz Fajferek
Tomasz Dariusz Fajferek
BPBarbara Zofia Pietrzyk
Barbara Zofia Pietrzyk
Surgical wound complications, particularly surgical site infection (SSI), remain common despite advances in perioperative care, and modern dressings—including emerging smart systems—are intended to optimize moisture balance, reduce bioburden, and support monitoring of healing. This narrative review, informed by PRISMA 2020, synthesized comparative clinical evidence on postoperative dressings across surgical specialties. PubMed and Embase were searched for peer-reviewed comparative human studies published in 2015–2025 involving adults undergoing surgery with primary closure or secondary intention healing. Outcomes included SSI, time to epithelialization/closure, scar outcomes, pain, peri-wound skin integrity, and dressing change frequency. Nine studies met the inclusion criteria across orthopedics, general and endocrine surgery, otolaryngology, maxillofacial surgery, and surgical oncology. In hip/knee arthroplasty, hydrofiber dressings were associated with lower SSI rates versus standard/absorbent dressings. A meta-analysis suggested that moist and silver-based dressings generally outperformed gauze, with ionic silver ranking highest for healing and metallic silver for SSI prevention, and hydrocolloids reduced dressing change frequency. Oxygen diffusion therapy improved scar outcomes after cervicotomy, and chitosan gel reduced synechiae after endoscopic sinus surgery. Evidence in oncologic surgery was inconclusive, and heterogeneity in interventions, endpoints, and follow-up limited pooling. Overall, advanced postoperative dressings may improve selected outcomes compared with traditional gauze, but effects appear procedure- and context-dependent; future studies should standardize outcomes, extend follow-up, and incorporate cost-effectiveness and patient-reported measures, alongside evaluation of sensor-enabled smart dressings.

2 September 2025 in Annales Academiae Medicae Silesiensis
Verified
Journal Article
Open access
BPBarbara Zofia Pietrzyk
Barbara Zofia Pietrzyk
PDPatrycja Dolibog
Patrycja Dolibog
TFTomasz Dariusz Fajferek
Tomasz Dariusz Fajferek
AJAleksander Joniec
Aleksander Joniec
JMJedrzej Mikolajczyk
Jedrzej Mikolajczyk
EKEmilia Kołodziej
Emilia Kołodziej
Wstęp: Większość dostępnych raportów naukowych na temat etiopatogenezy COVID-19 koncentruje się głównie na populacjach dorosłych z zaawansowanymi stadiami chorób przewlekłych, w tym ciężkimi zaburzeniami układów oddechowego i sercowo-naczyniowego, a także schorzeniami onkologicznymi, w których zaobserwowano korelację z przebiegiem klinicznym choroby. Przebieg kliniczny COVID-19 jest bardzo zmienny, od bezobjawowych lub łagodnych objawów do ciężkiej niewydolności oddechowej i krążeniowej oraz zgonu. Celem badania była ocena, czy powszechne choroby przewlekłe wpływają na nasilenie objawów klinicznych COVID-19.Materiał i metody: Badanie retrospektywne prowadzono w grupie 208 pacjentów w okresie od października 2022 r. do lutego 2023 r. Autorski kwestionariusz zawierał dane dotyczące objawów po COVID-19 i ich nasilenia (łagodne, umiarkowane lub ciężkie), częstości występowania oraz związku z chorobami współistniejącymi. Zastosowano statystyki opisowe, przy istotności statystycznej p < 0,05. Porównania zmiennych dokonano za pomocą testu χ².Wyniki: Spośród pacjentów 50,48% cierpiało na choroby przewlekłe, z czego u 55% wystąpiły łagodne objawy COVID-19, a u 40% umiarkowane. W grupie bez chorób przewlekłych (49,52%) łagodne objawy zaobserwowano u 58%, a umiarkowane u 36%. Nie stwierdzono istotnej korelacji między chorobami przewlekłymi a nasileniem objawów (p = 0,809).Wnioski: Nie stwierdzono istotnej korelacji między powszechnymi chorobami przewlekłymi a nasileniem objawów COVID-19. Rodzaj, nasilenie i czas trwania schorzeń, a także poziom wiremii wpływają na rokowanie. Konieczne są dalsze badania uwzględniające dodatkowe czynniki, takie jak płeć i wiek.

1 January 2026 in Medical Studies
Verified
Journal Article
Open access
TFTomasz Dariusz Fajferek
Tomasz Dariusz Fajferek
JMJedrzej Mikolajczyk
Jedrzej Mikolajczyk
AJAleksander Joniec
Aleksander Joniec
SKSeweryn Kaczara
Seweryn Kaczara
EMEmma Mażul-Kulesza
Emma Mażul-Kulesza
BPBarbara Zofia Pietrzyk
Barbara Zofia Pietrzyk
Body temperature is a key vital sign, but traditional intermittent monitoring in hospitals increases nursing workload. Continuous monitoring via wearable sensors could improve efficiency and early deterioration detection, but systematic evidence remains scarce. This study therefore aimed to evaluate the clinical application of the SteadyTemp® and TempTraq® wireless temperature sensors for integration into clinical care protocols. A narrative review of the literature (PubMed/Embase, 2020–2025) including 58 clinical studies was conducted. The systems were compared in terms of accuracy, battery life, patient comfort, data security, and integration with hospital information systems/electronic medical records. Statistical analysis included means, standard deviations, and trend analysis. Both systems demonstrated clinical utility but differed in application. SteadyTemp® offers stable 7-day monitoring and GDPR-compliant data integration, suiting hospital use. TempTraq® provides high real-time accuracy (measurements every 10 s), benefiting paediatrics, but has a shorter 72-hour lifespan and higher cost. Wireless sensors are a valuable complement to traditional methods, enabling continuous, automated monitoring. SteadyTemp® is optimal for hospital settings, while TempTraq® is ideal for short-term paediatric fever detection, improving workflow and supporting early infection detection.

10 June 2026 in Annales Academiae Medicae Silesiensis
Verified
Journal Article
Open access
JMJedrzej Mikolajczyk
Jedrzej Mikolajczyk
AJAleksander Joniec
Aleksander Joniec
EMEmma Mażul-Kulesza
Emma Mażul-Kulesza
JGJakub Gonscz
Jakub Gonscz
TFTomasz Dariusz Fajferek
Tomasz Dariusz Fajferek
Agata StanekAgata Stanek
Agata Stanek
Primary pulmonary sarcomas are exceptionally rare, and pulmonary spindle cell sarcomas represent an even rarer, highly aggressive subset. Their clinical presentation is often nonspecific, and rapid local invasion may culminate in malignant spinal cord compression (MSCC), posing urgent diagnostic and therapeutic challenges. A 60-year-old man with a history of follicular lymphoma treated with O-CHOP and obinutuzumab maintenance subsequently developed a metachronous undifferentiated spindle cell sarcoma of the right upper lobe with pleural dissemination (FNCLCC grade 2). Despite multimodal therapy including cisplatin/etoposide and thoracic radiotherapy, followed by ifosfamide-imaging in June 2025 demonstrated rapid progression. Right-sided video-assisted thoracoscopic surgery revealed a massive, unresectable tumor infiltrating the chest wall. A subsequent gemcitabine/docetaxel regimen was initiated; shortly thereafter, the patient developed acute urinary retention and rapidly progressive lower-limb sensory symptoms evolving to paraparesis. Computed tomography showed a 127 × 99 × 165 mm right upper-lobe mass with osseous invasion and intraspinal extension at Th4–Th6 and Th11–Th12, with additional liver and bilateral renal metastases. Laboratory testing demonstrated severe anemia, thrombocytopenia, and markedly elevated inflammatory markers. Management included transfusion support, high-dose corticosteroids, antibiotics for MRSE urinary infection, and opioid-based analgesia. Given disseminated disease and ECOG 4 performance status, neurosurgical decompression and further systemic therapy were withheld, and the patient was discharged to home hospice. Abrupt neurological deterioration in aggressive thoracic sarcoma mandates urgent evaluation for MSCC; in terminal disseminated disease, early goal-concordant palliative care is essential.