Background and objectives: Atherosclerotic cardiovascular disease (ASCVD) remains a major global cause of mortality, with chronic infections and systemic inflammation, including those arising from periodontal pathogens, contributing to vascular pathology. This study aims to investigate the presence of bacterial DNA from oral cavity microorganisms in atherosclerotic plaques of patients with abdominal aortic aneurysm (AAA) and to explore correlations with oral health indices and clinical variables. Materials and Methods: Forty patients (mean age 61 ± 6 years; 60% male) with periodontitis and AAA were included. Subgingival biofilm and arterial plaque samples were analyzed using PCR for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythensis, and T. denticola. Dental indices (PI, GI, SBI, and PPD) were determined in all patients, and concordance of the findings was assessed by Cohen’s κ, and correlations were evaluated using Spearman’s coefficient. Results: P. gingivalis exhibited the highest concordance between oral and arterial plaques, followed by T. forsythensis and A. actinomycetemcomitans. T. denticola DNA was not detected in aortic samples. Positive correlations found between A. actinomycetemcomitans and P. gingivalis with dental indices were found to be statistically significant. Conclusions: The detection of periodontal pathogens, particularly P. gingivalis and T. forsythensis, in both oral and arterial plaques supports their potential role in atherosclerotic and aneurysmal changes. The findings highlight the relevance of periodontal health in cardiovascular risk prevention and the need for longitudinal studies to reveal causal mechanisms.

Cancers of the oral tongue (OT) and floor of the mouth (FOM) are frequently grouped together as carcinomas of the tongue and floor of the mouth (OTFOM). The incidence rate of these cancers varies worldwide from 0.1/100,000 persons a year for females in Algeria, Chile and Korea to 7.4/100,000 persons a year for men in New Delhi, India. The aim of this study was to analyze the trends in age-standardized incidence rates of oral tongue cancer in the Belgrade population during the period of past 12 years. The data were obtained from the Serbian Cancer Registry (The Registry). Age-standardized incidence rates were calculated using the direct standardization method to the world standard population and presented as an incidence rate per 100,000 persons a year. Joinpoint regression analysis was used to analyze the trends and annual percentage change (APC). The results of the joinpoint regression analysis showed an increasing trend of OT cancers for both genders, with an APC of 4.1% among men and 1.7 % among women. The incidence rate for FOM cancers increased, with an APC of 4.8% among men and 6.8% among women. Our results showed a continuously increasing incidence rate of oral tongue and floor of the mouth carcinoma in the capital of the Republic of Serbia.

The article discusses the history, development, and properties of gold dental alloys. Alloys produced by Zlatarna Celje d.o.o. are certified medical devices in class IIa according to Regulation (EU) 2017/745, indicating a moderate level of risk. Alloys for porcelain crowns and bridges have a special status, requiring specific chemical composition and processing. Future development should aim to minimize biological risks and corrosion, achievable with highly noble alloys with stable microstructure. Dental alloys must not be ferromagnetic. Correct chemical composition is crucial for each patient, as the market offers various alloys suitable for individuals with different allergies and specific conditions in their oral cavity. It is important to follow the manufacturer's recommendations to ensure the quality fabrication and installation of dental prosthetic constructions.

Background and Objectives: Malignant tumors of the oral cavity are an important and growing component of the global cancer burden, with well-documented sex disparities in incidence. This study aimed to characterize temporal trends in the incidence of these tumors in the Republic of Serbia between 1999 and 2020, overall and by sex, and to forecast incidence through 2040. Materials and Methods: All histopathologically verified cases (ICD-10: C01–C06, excluding the lip) reported to the Cancer Registry of the Republic of Serbia (excluding the Autonomous Province of Kosovo and Metohija, for which data are unavailable) were analyzed retrospectively. Age-standardized incidence rates (ASRs; world standard population) were calculated, and joinpoint regression estimated the annual percentage change (APC) with 95% confidence intervals (CI). Autoregressive Integrated Moving Average (ARIMA) models projected incidence to 2040, with sensitivity analyses for the 2016 extension of Registry coverage. Results: A total of 5695 cases were registered (3872 men, 1823 women). Restricted to the population under consistent Registry coverage (Central Serbia, 1999–2015), incidence did not change significantly in either sex (men: APC = −0.30%, 95% CI: −1.63, 1.06; women: APC = −3.31%, 95% CI: −7.41, 0.96). Over the full 1999–2020 series, which includes the 2016 extension of coverage to Vojvodina, incidence appeared to rise among men (APC = 1.71%; 95% CI: 0.47, 2.96; p = 0.009), with an apparent acceleration after 2013 (APC = 8.39%; p = 0.002); a level-shift model and a formal comparison of competing trend descriptions both attributed this apparent rise to the 2016 coverage change rather than to a genuine trend (+50.7%; p < 0.001). Male incidence was about twice that in women (mean ASR 3.63 versus 1.64). Under an unchanged-coverage scenario, ARIMA models projected a flat mean incidence through 2040 (2.6 per 100,000 overall; 4.7 in men, with a 95% prediction interval widening from 3.6–5.8 in 2021 to 1.2–8.2 in 2040), with a considerably less precise and less reliable forecast for women. Conclusions: Oral cavity cancer incidence in Central Serbia was stable from 1999 to 2015, with a persistent male excess. The apparent post-2013 rise is attributable to the 2016 extension of registry coverage rather than to a genuine trend, and a counterfactual estimate suggests considerably higher incidence in Vojvodina. Region-stratified reporting is needed before national trends can be interpreted reliably.