Many small ruminants infected with foot-and-mouth disease (FMD) remain asymptomatic, with the capacity to promote silent viral spread within domestic and wildlife species. However, little is known about the epidemiological role played by small ruminants in FMD. In particular, there are few studies that examine FMD seroprevalence, spatial patterns and risk factors for exposure in small ruminants. A cross-sectional study was conducted in northern Nigeria (Bauchi, Kaduna, and Plateau States) to determine the true seroprevalence of FMD in backyard small ruminants, identify factors associated with FMD seroconversion at animal and household levels, and identify spatial patterns for FMD virus exposure. Data on animal (n = 1800) and household (n = 300) characteristics were collected using a standardised questionnaire. Sera samples from 1800 small ruminants were tested for antibodies against non-structural proteins of FMD virus. True seroprevalence was estimated stochastically to account for variability and uncertainty in the test sensitivity and specificity previously reported. Risk factors for FMD seropositivity were identified at animal and household levels and spatial patterns were determined. The overall true seroprevalence for FMD virus, in the small ruminant population tested, was estimated to be 10.2 % (95 % Credible Interval (CrI) 0.0-19.0), while State-level estimates were 17.3 % (95 % CrI 0.0-25.8) for Kaduna, 6.9 % (95% CrI 0.0-15.8) for Bauchi, and 3.6 % (95 % CrI 0.0-12.6) for Plateau. State and species were the main risk factors identified at animal level, with interaction detected between them. Compared to goats in Plateau, the odds of testing positive were higher for goats in Bauchi (Odds Ratio (OR)= 1.83, 95 % CI 1.13-2.97, p = 0.01) and Kaduna (OR=2.97, 95 % CI 1.89-4.67, p < 0.001), as well as for sheep in Plateau (OR=3.78, 95 % CI 2.08-6.87, p < 0.001), Bauchi (OR=1.61, 95 % CI 0.91-2.84, p = 0.10), and Kaduna (OR=3.11, 95 % CI 1.61-6.01, p = 0.001). Households located in Kaduna were more likely to have a higher number of seropositive SR compared to those in Plateau (Prevalence Ratio (PR)= 1.75, 95 % CI 1.30-2.36, p < 0.001), and households keeping sheep flocks were more likely to be seropositive (from 1 to 10 sheep: PR=1.39, 95 % CI 1.05-1.82, p = 0.02; more than 10 sheep: PR=1.55, 95 % CI 1.12-2.15, p = 0.008) compared to those that did not keep sheep. A hot-spot was detected in Kaduna, and a cold-spot in Plateau. These results reveal that small ruminants had been recently exposed to FMD virus with spatial heterogeneity across the study area.

Crimean-Congo hemorrhagic fever (CCHF) and Rift Valley fever (RVF) are major zoonotic diseases, spread by arthropods, with livestock serving as amplifying hosts. Despite Nigeria’s large ruminant population and robust cross-border animal trade, data on the seroprevalence of the viral agents causing these diseases remain limited. A longitudinal serological survey was conducted in five major livestock markets across Nigeria. A total of 3450 animals (cattle, sheep, and goats) were tested for Crimean-Congo hemorrhagic fever virus (CCHFV) and Rift Valley fever virus (RVFV) antibodies using ELISA. Data on species, age, sex, animal origin, and tick infestation were collected and analyzed. Overall seroprevalence was 27.1% (95% CI: 25.6–28.6) for CCHFV and 5.8% (95% CI: 5.1–6.7) for RVFV. Cattle showed the highest prevalence for both CCHFV (55.4%) and RVFV (11.2%), followed by sheep (17.4% and 2.9%) and goats (8.6% and 3.4%). Evidence of mixed exposure to both CCHFV and RVFV antibodies was detected in 8.2% of cattle, 0.7% of sheep, and 0.2% of goats. Seropositivity was higher in older animals, females, tick-infested animals, and those of Nigerian origin compared to imported animals. Market-level variation was observed, with Mubi livestock market showing the highest CCHFV prevalence (35.5%) and Illela livestock market the highest RVF prevalence (11.2%). The detection of con-current CCHFV and RVFV antibodies, alongside high CCHFV prevalence and detectable RVFV circulation among Nigerian livestock highlight the risk of zoonotic spillover, particularly in livestock markets with intense human–animal interaction.

Multiple transboundary animal diseases (TADs) circulate in Plateau State, Nigeria, where livestock keeping is common and contributes to both the physical and socio-economic well-being of a large proportion of the population. In this study, we explored the potential for environmental sampling to detect viruses causing TADs circulating in the region. Electrostatic dust cloths were used to swab areas of the environment likely to have contact with secretions and excretions from infected animals. Samples were collected monthly from five households, one transhumance site and one livestock market in two local government areas in Plateau State between March and October 2021. These were tested for the presence of peste des petits ruminants virus (PPRV) and capripox viruses using real-time PCR. Of the 458 samples collected, 2.4% (n = 11) were positive for PPRV RNA and 1.3 % (n = 6) were positive for capripox virus DNA. A capripox differentiation assay showed that these samples were positive for sheep pox virus (n = 2), goat pox virus (n = 2) and lumpy skin disease virus (n = 2). Our results demonstrate that environmental sampling could be used as part of TAD surveillance in the area. Environmental swabs require little technical knowledge to collect and can be used to detect multiple viruses from a single sample.

Rift Valley Fever (RVF) is a neglected vector-borne zoonotic disease of significant veterinary and public health concern in Sub-Saharan Africa. This study investigated the seroprevalence of Rift Valley Fever Virus (RVFV) exposure and associated risk factors among camels and horses marketed in northern Nigeria. A total of 1117 animals were sampled, comprising camels (812) and horses (305), across three major livestock markets (Maigatari, Maiduguri, and Illela). The overall seroprevalence was 18.8% (95% CI: 16.6–21.2%), with a striking six-fold disparity: camels showed a prevalence of 24.4% (95% CI: 21.6–27.4%), while horses exhibited only 3.9% (95% CI: 2.1–7.0%). Significant geographic clustering was observed, with Illela camels recording the highest prevalence (34.8%) compared to those in Maigatari (20.3%) and Maiduguri (20.2%). There were no significant associations with age or sex among camels. However, in horses, females were significantly more likely to test positive than males (OR = 0.27, 95% CI: 0.07–0.97). These findings demonstrate endemic RVFV circulation in Nigerian livestock, highlighting species- and location-specific differences, and underscore the zoonotic risks within regional and transboundary livestock trade networks.

Rift Valley fever virus (RVFV) is a zoonotic arbovirus of major public health and veterinary importance in Africa, yet its inter-epidemic transmission dynamics and baseline endemicity in Nigeria remain insufficiently synthesized relative to classic outbreak-prone regions. This scoping review systematically synthesizes over six decades of evidence (1959–2024) on the epidemiology, prevalence, transmission dynamics, diagnostics, and control of RVFV in Nigeria. Following PRISMA-ScR guidance, 24 peer-reviewed primary articles were included (following comprehensive systematic screening across electronic databases and grey literature sources) across human, livestock, wildlife, and vector populations. The evidence indicates that RVFV in Nigeria represents a long-established endemic zoonosis sustained through silent, low-amplitude transmission rather than explosive epidemics. Serosurveys in domestic livestock demonstrated an overall seroprevalence ranging from 3.3% to 33.3% across regions and species (most study estimates clustering between 5 and 30%), with higher values in northern pastoral regions characterized by transhumance, wetlands, and cross-border animal movement. Human seroprevalence is consistently lower (< 20%) and largely confined to occupationally exposed groups, suggesting under-recognition of infection due to non-specific clinical presentation and limited routine diagnostics. Entomological data implicate key mosquito vectors (predominantly Culex species) alongside biting midges (Culicoides spp.) and evidence of wildlife exposure, supporting a complex, ecologically resilient transmission system that enables year-round circulation independent of extreme climatic events. Diagnostic invisibility, fragmented surveillance, and weak One Health integration remain major constraints, while documented control interventions are scarce. Recent advances in molecular diagnostics, participatory epidemiology, and integrated One Health responses in other African countries highlight actionable opportunities for strengthening RVFV surveillance and control in Nigeria. This review underscores the urgent need for integrated, multi-sectoral surveillance and proactive control strategies to address the under-estimated burden of RVFV in Nigeria.