Introduction: Acute coronary syndrome (ACS), encompassing unstable angina, NSTEMI, and STEMI, is a major cause of morbidity and mortality worldwide. Novel inflammatory and nutritional biomarkers may provide incremental value for risk stratification beyond conventional predictors. This work sought to determine whether the Pan-Immune-Inflammatory Value (PIV) and the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score could serve as independent prognostic indicators in individuals presenting with acute coronary syndrome. Methods: A retrospective multicenter study included ACS patients hospitalized between January 2020 and May 2024. Demographics, clinical data, and laboratory results were collected. PIV was calculated as follows: neutrophils × platelets × monocytes/lymphocytes. HALP score was calculated as follows: hemoglobin × albumin × lymphocytes/platelets. Correlations with clinical parameters and mortality prediction were analyzed. Results: A total of 1134 patients (mean age 62 ± 12 years) were included. PIV showed positive correlations with WBC (Rho = 0.574), troponin (Rho = 0.381), and CRP (Rho = 0.295), and negative correlations with HDL (Rho = –0.101) and ejection fraction (Rho = –0.316) (all p < 0.01). PIV independently predicted mortality with a cut-off ≥1074.2 (AUC = 0.619, sensitivity 45%, specificity 79.9%). HALP score negatively correlated with age, troponin, CRP, and ICU stay, and predicted mortality with a cut-off ≤3.58 (AUC = 0.722, sensitivity 53.8%, specificity 82%). Comparative ROC analysis showed that HALP demonstrated superior discriminative ability for mortality prediction compared with PIV. Conclusions: PIV and HALP score are independent prognostic markers in ACS, reflecting inflammatory burden and nutritional status. Their integration into clinical workflows may enhance risk stratification and support individualized management strategies. Given their simplicity and universal availability, PIV and HALP may serve as practical adjunctive tools to established risk scores, enabling early identification of high-risk ACS patients at the time of admission.

Aim: The authors investigated the association of red blood cell distribution width to albumin ratio (RAR) with prognosis and severity in acute ischemic stroke (AIS). Methods: One hundred twenty-sev...

This study evaluated the Hemoglobin to Red Cell Distribution Width Ratio (HRR) and Red Cell Distribution Width to Albumin Ratio (RAR) in acute pericarditis patients, exploring associations with clinical parameters. A retrospective cohort study included 257 patients diagnosed with acute pericarditis (2015-2023). Data on hemoglobin, RDW, albumin, treatments, hospital stay, and recurrence were analyzed using SPSS 27.0. The mean age was 41 years. HRR averaged 1.067 ± 0.142, and RAR was 0.311. Men had higher hemoglobin and albumin levels, while women had higher platelet and HDL levels. Lower HRR correlated with severe conditions and recurrence, while higher RAR was linked to disease severity and recurrence. Both markers were strongly associated with pericardial effusion and IV steroid need. HRR and RAR are valuable biomarkers in acute pericarditis, aiding in assessing disease severity and guiding treatment.

Because earlier studies have proven a link between hemoglobin, albumin, lymphocyte, and platelet (HALP) and pan-immune-inflammation value (PIV) scores and inflammation, we examined if these 2 markers had predictive value in patients with atrial fibrillation (AF). In the intensive care unit, 444 patients with and without AF were retrospectively analyzed. Patients with and without AF were compared with regard to their HALP and PIV scores. High and low categories of HALP and PIV scores were established based on the cutoff values. Furthermore, using receiver operating characteristic analysis, the mortality predictive efficacy of these scores was assessed in 230 patients with AF. Patients with AF had a significantly higher PIV score than those without AF; however, the HALP score found to be lower (P < .05 for all groups). The receiver operating characteristic analysis revealed that the HALP score exhibited a sensitivity of 66.7% and a specificity of 75.3% at a cutoff value of 2.037 (AUC: 0.753, P < .001). The PIV score cutoff value was 1062.7, but the sensitivity and specificity were both 55.7% and 55.8%, respectively (AUC: 0.571, P < .05). The mechanical ventilation requirement and in-hospital mortality rate were significantly higher in the high PIV (PIV > 1062.7) and low HALP (HALP ≤ 2.037) groups. There is a significant association between the HALP and PIV scores assessed upon admission and critically ill patients with AF. Although the HALP score serves as a powerful prognostic factor for these patients, the PIV lacks the capability to predict mortality.

Aim: This study investigates the prognostic value of the Hemoglobin/Red Blood Cell Distribution Width Ratio (HRR) and the Red Blood Cell Distribution Width/Albumin Ratio (RAR) in patients with myocarditis. We aimed to evaluate how these novel biomarkers correlate with clinical parameters, disease severity, and outcomes. Methods: A retrospective analysis was conducted on 301 patients diagnosed with myocarditis between January 2020 and March 2024. Inclusion criteria were adults with confirmed myocarditis based on clinical, ECG and echocardiographic evaluations. Exclusion criteria included incomplete records and prior immunosuppressive therapy. We assessed various blood parameters, including HRR and RAR, and analyzed their associations with clinical outcomes, hospital stay duration, and complications. Results: The study found that HRR and RAR were significantly associated with several clinical outcomes in myocarditis patients. Higher HRR values correlated with improved outcomes, while higher RAR values were linked to worse outcomes. HRR was associated with pericardial effusion, inotropic support, and other parameters, while RAR was correlated with similar factors, including recent gastroenteritis. Patients with longer hospital stays exhibited higher inflammation markers and lower ejection fractions, underscoring the severity of their condition. Conclusion: HRR and RAR are promising biomarkers for assessing disease severity and prognosis in myocarditis. They provide additional prognostic information beyond traditional markers such as troponin and CRP, potentially guiding more personalized treatment strategies.