Background: The aim of our study was to evaluate the retinal nerve fiber layer (RNFL) and macular and choroidal thicknesses in women with different phenotypes of polycystic ovary syndrome (PCOS), and compare these measurements with those of healthy women of reproductive age. Materials and Methods: This prospective case–control study included 120 eyes of 120 women with PCOS, with each of the four distinct phenotypes comprising 30 eyes of 30 women. Additionally, 30 eyes from 30 healthy women were included in the control group. All participants underwent comprehensive ophthalmologic examinations, and RNFL thickness, macular thickness (MT), and choroidal thickness (CT) in each eye were measured via spectral-domain optical coherence tomography. The body mass index (BMI) of the patients was recorded and compared with the retinal changes. Results: The average mean and nasal segments of the RNFL were significantly greater in the PCOS group than in the healthy control group (p < 0.001). There was a statistically significant difference in foveal retinal thickness between the groups (p < 0.001). Our study revealed significant choroidal tissue thickening subfoveally and at locations 500 μm temporal, 500 μm nasal, 1500 μm nasal, and 1500 μm temporal to the fovea in all phenotypes of the PCOS group (p < 0.001). Additionally, there was a positive correlation between BMI and all CT changes. Conclusions: Our findings indicate that the retinal layers and choroid are affected by all phenotypes of PCOS, one of the most common reproductive abnormalities, albeit to varying degrees. Furthermore, these changes were found to be correlated with BMI.

Objective: Abnormal uterine bleeding is an important symptom frequently encountered in the gynecology outpatient clinic. In our study, it was aimed to determine the endometrial pathologies that cause abnormal uterine bleeding. Material and methods: The pathology results of patients who applied to our clinic with the complaint of abnormal uterine bleeding and underwent endometrial sampling were retrospectively analyzed. Findings were classified and compared according to whether the patients were in the postmenopausal or premenopausal period. Results: A total of 878 patients were included in the study. The mean age of the patients was 47.59±7.91/year. The most common symptom was menometrorrhagia 58.1%. The most common pathological finding was endometrial polyp in both premenopausal and postmenopausal patients (29.69% and 24.31%). The incidence of premalignant and malignant lesions was 2.7% in premenopausal patients and 8.25% in postmenopausal patients. Conclusion: Abnormal uterine bleeding may be associated with malignancies in both postmenopausal and premenopausal patients. Performing endometrial sampling in patients presenting with this symptom is of great importance in providing early diagnosis and treatment of malignant and premalignant lesions.

Background/Objectives: Preeclampsia is a leading cause of maternal and perinatal morbidity worldwide, yet its underlying mechanisms remain unclear. Polyunsaturated fatty acids, particularly docosahexaenoic acid (DHA), are essential for placental development and vascular function, but evidence on their role in preeclampsia is inconsistent. This study aimed to compare serum DHA levels between women with preeclampsia and normotensive pregnant women and to examine their association with disease severity and maternal and perinatal outcomes. Methods: A total of 145 pregnant women aged 18–40 years were enrolled, including 47 with newly diagnosed preeclampsia (PE) and 98 normotensive controls. PE was defined according to the ACOG 2019 criteria. Serum DHA levels were measured using ELISA in fasting blood samples collected at the first visit. Results: Maternal serum DHA levels did not differ significantly between preeclampsia and control groups (p = 0.571); they were similar across control, mild PE, and severe PE groups. DHA showed a negative correlation with neutrophil-to-lymphocyte ratio (r = −0.305) and maternal hospitalization duration (r = −0.334). Independent predictors of PE included nulliparity (OR: 4.43), advanced age (OR: 1.14), elevated BMI (OR: 1.29), and low albumin (OR: 0.77). After adjusting for age and BMI, DHA was an independent negative predictor of IUGR (OR: 0.65). Conclusions: DHA levels: Placental and/or fetal DHA metabolism may be impaired in patients with preeclampsia. Although DHA was not associated with the development of PE, it was a negative predictor of IUGR. DHA reduces the length of maternal hospital stay through its anti-inflammatory effect.

Introduction: Cesarean section is an operation that carries a higher risk compared to normal vaginal delivery in terms of bleeding. In this study, we aimed to compare hemoglobin decreases in pregnant women who had normal vaginal delivery and cesarean section. Material and methods: In this study, pregnant women who had normal vaginal delivery and cesarean section between 01.01.2021 and 30.06.2022 in a university hospital were analyzed retrospectively. The pregnant women included in the study were standardized as those between the ages of 18-45, who did not have any systemic disease, and who gave birth to a baby between 2000-4000 gr at 37-41 weeks of gestation. The patients included in the study were divided into two groups as those who had normal vaginal delivery and cesarean section, and those who delivered by cesarean section were divided into two groups as primary cesarean section and previous cesarean section, and the decreases in hemoglobin levels taken before and at the 6th hour after delivery were statistically evaluated. Results: It was determined that 199 of the 473 pregnant women included in the study had normal delivery and 274 had a cesarean section (119 had a previous cesarean section and 155 had a primary cesarean section). Among the pregnant women included in the study, the mean postpartum Hb decrease was 0.73 ± 0.90 g/dl in the pregnant women who had normal delivery, and 1.41 ± 0.93 g/dl in those who delivered by cesarean section, the difference was found to be statistically significant (p=0.000). The mean postpartum Hb decrease in those who underwent cesarean section with a previous cesarean indication was 1.30 ± 0.73 g/dl, and 1.49 ±0.9 g/dl in primary cesarean sections, the difference was statistically significant (p=0.045). Conclusion: With these results determined in accordance with the literature, it would be appropriate to take the necessary precautions by taking these findings into account when making a cesarean section decision.