Age‐related alterations in the immune system—collectively known as immunosenescence—include both quantitative and qualitative changes across various immune cell populations, including B cells, natural killer cells and T lymphocytes, affecting their structure, phenotype and function. While these changes have been characterised biochemically and physiologically, their biophysical manifestations remain less understood, particularly in individuals that achieve exceptional longevity. Here, we investigate the mechanical and structural properties of memory CD4 ⁺ T cells from mice across three aging stages: old (72 ± 4 weeks), very old (96 ± 4 weeks) and long‐lived (> 120 weeks). We conducted a cross‐sectional analysis combining micropipette aspiration, 3D confocal microscopy, spontaneous migration assays and flow cytometry to evaluate cellular stiffness, motility, nuclear morphology and cytoskeletal organisation. Our results confirm previous reports of increased stiffness and reduced migration in T cells from very old mice. However, this trend does not persist in long‐lived individuals, who display mechanical and migratory properties similar to younger cohorts. Relative nuclear size ( R _n / R _c ) and actin organisation also stabilise in this group, suggesting the maintenance of intracellular architecture despite advanced chronological age. Notably, no significant changes were found in the expression levels or distribution of key structural proteins (actin, myosin, vimentin), nor in markers of DNA methylation (5‐mC) or cellular senescence (p16). These findings support the concept of mechanical resilience in the immune system as a feature of successful aging, highlighting that certain biophysical traits may be preserved or selectively maintained in extreme longevity. This study provides novel evidence linking T cell mechanics with immune health and longevity and identifies candidate parameters for future investigations into aging biomarkers.

Obesity is a worldwide epidemic that has become a risk factor for the development of respiratory problems, meaning it is necessary to generate models that assess lung function in obese patients for proper treatment. The objective of this study was to evaluate a model for analyzing respiratory function according to body composition, by analyzing the structure and function of the airways by computed tomography (CT). Lung function and body fat percentage (BF%) were measured in three male subjects (25 ± 6 years), with different body mass index (BMI; normal, overweight, obese). A third-dimensional (3D) reconstruction of the airways was performed using CT. Trachea, right and left main bronchi and anterior segmental bronchus of the right and left lung were measured. Three measurement points were established for each structure, and the average value of these three points was used for the analysis. An increase in the thickness of the airways wall of the left and right main bronchi and right segmental bronchus was observed as BMI and BF% increased. The same was observed for the percentage of airway wall area (%AWA) and airway resistance in the main and segmental bronchi. The proposed 3D reconstruction model and the three-point analysis simplified image assessment and allowed to observe the problems caused by obesity in lung function.