This study focuses on obtaining lignin-based hydrogels from pruning residues of orange trees in the Safor region (Valencia) using an alkaline extraction method. The structural analysis of the obtained lignin was carried out using Fourier-transform infrared spectroscopy (FTIR), which revealed the characteristic functional groups of lignin, as well as its structural monolignols: syringyl and guaiacyl. The thermal properties were analyzed using differential scanning calorimetry (DSC) and thermogravimetric analysis. The DSC thermogram revealed a relatively low glass transition temperature (T_g) of 67 °C, which may be attributed to partial lignin chain degradation during alkaline extraction. Soda lignin was obtained at 190 °C with an approximate yield of 10.8% relative to the initial biomass and subsequently used to synthesize poly(vinyl alcohol) (PVA)-based hydrogels for ibuprofen encapsulation. Finally, the release experiments of the encapsulated ibuprofen were carried out in an aqueous phosphate buffer medium (pH = 7) at room temperature. A multi-curve response analysis (MCR) algorithm using the Korsmeyer–Peppas (KP) concentration model was used to analyze the release curves, which concluded that the drug and water-soluble lignin fraction (SLF) were released at different rates. For both components, a good correlation was obtained between the measured responses and those provided by the KP model. The release profile indicated that approximately 87% of the initial ibuprofen load was released from the hydrogel within 5 h, highlighting the promising potential of lignin-based hydrogels for drug delivery applications.