Successive ionic layer adsorption reaction (SILAR) was used to deposit Cu₂O nanosheets on anodized TiO₂ nanotubes at different deposition cycles (4, 8, 15, and 20). Compared to the bare TiO₂ nanotubes, these coatings were investigated for their tribological behavior (friction, wear and energy loss), scanning and transmission electron microscopy (SEM, TEM), X-ray Diffraction (XRD) was used to characterize Cu₂O/TiO₂ coatings to study the effect of number of cycles on the morphological and structural properties of the samples; these characteristics engage in determining the wear mechanisms. The assessment of the coating’s adhesion was determined by the obtained critical loads from the scratch test; the 15 cycles Cu₂O/TiO₂ exhibited higher critical loads, which corresponds to improved adhesion. This sample also showed a low wear volume of 7.5 × 10⁶ µm³ compared to other samples but higher energy loss due to the low shear strength of copper oxide. The friction coefficient, however, decreased from 0.7 for bare TiO₂ nanotubes to 0.48 for 20 cycles Cu₂O/TiO₂ coatings at higher loads, which proves the wear resistance enhancement. Since these coatings will be manufactured for orthopedic and dental implant applications, the corrosion resistance was tested, and the 15 cycles Cu₂O-NPs/TiO₂-NTs where these coatings exhibited the most favorable combination of a low corrosion current density (1.9 × 10⁻⁴ A/cm²) and a noble corrosion potential (−0.3 V/SCE); furthermore, there was a polarization resistance of 2.4 × 10⁴ Ω·cm² and a protection efficiency of 96.7%, indicating significantly enhanced corrosion resistance as opposed to the other samples.