OBJECTIVE: In this study, we aimed to determine the phenolic compounds, the antibacterial activity of extract from Laurus nobilis leaves, and its possible effect on transforming growth factor-β1 expression level in peripheral blood mononuclear cells.

Numerous studies have demonstrated that the brain and blood–brain barrier, which are sensitive targets for cell phone and microwave radiation, are damaged after exposure. Additionally, ginseng has been shown to play a role in preserving the integrity of the blood–brain barrier. In this study, we investigated the immunohistochemical, genetic and biochemical effects of electromagnetic field (EMF) on the blood–brain barrier (BBB) and the protective role of ginseng on these effects. The animals were randomly allocated into seven groups (eight in each group): group I: control, group II: sham, group III: ginseng, group IV: 2100 MHz EMF, group V: 2100 MHz EMF + ginseng, group VI: 2450 MHz EMF, group VII: 2450 MHz EMF + ginseng. EMF groups exposed to EMF, 1 h day⁻¹ for 30 days. Ginseng was administered 150 mg/kg/day for 30 days. As a result, it was determined immunohistochemically that EMF caused apoptosis in brain tissue. It was observed that cyclooxygenase-2 (COX-2) gene decreased and B-cell lymphoma/leukemia-2 gene (BCL-2)-associated X (BAX) protein increased in EMF groups, as well as apoptosis formation. On the other hand, it was concluded that ginseng decreased the harmful effects by increasing the expression of the COX-2 gene and decreasing the BAX protein in this process leading to apoptosis.

Obezite, genetik, çevresel faktörler ve bunların karmaşık etkileşimleri tarafından yönetilen birçok kronik hastalık ile ilişkilidir. Genetiğin obeziteye yatkınlıkta önemli rol oynadığı ve hastalık riskine %70'e kadar katkıda bulunabileceği tahmin edilmektedir. Yapılan genetik çalışmalar, genlerin obeziteye katkıda bulunduğunu doğrulamıştır. Genlerdeki anomaliler, Bardet- Biedl ve Prader-Willi sendromları gibi obezite ile ilişkili bozukluklardan doğrudan sorumludur. Genetik epidemiyolojik yaklaşımlar, özellikle genom çapında ilişkilendirme çalışmaları, insan obezitesinde önemli rol oynayan çok sayıda geni tanımlamıştır. Gelecekte, obezite genetiğinin daha fazla araştırılması, obezite tedavisi için yararlı teşhis testleri geliştirmeye yardımcı olabilir. Bu derleme ile obezite genetiği hakkında güncel literatür ile desteklenmiş bilgiler aktarılmıştır.

Objective: Epicatechin (EC) is one of the major components of green tea catechins. This study investigated the effect of the amount of epicatechin obtained by brewing green tea under optimal conditions against oxidative stress induced by hydrogen peroxide (H2O2). Materials and Methods: In peripheral blood mononuclear cells (PBMCs), the amount of epicatechin determined by brewing green tea under optimum conditions was applied against 250 µM H2O2 and cell viability was determined by MTT test, total antioxidant status (TAS) and total oxidant status (TOS) were determined by biochemical analysis, apoptosis-related Bax, Bcl2, p53 expression analysis was determined by qRT-PCR method. Results: The cell viability was significantly higher in the H2O2+EC group than in the H2O2 group (p