In structural engineering practice, the problem of thick plate bending occurs in designing shelters, foundations of high-rise buildings, counter-slabs, etc. In such cases, neglecting shear deformation can lead to significant errors in predicted behavior, especially when a plate is subjected to a concentrated force. In practice, neither a fully clamped nor an ideal simple support can be achieved during construction, so the plates are partially clamped, and this also applies to thick plates. Bending of thick rectangular plates with partially clamped edges has not been studied in the literature, so this paper addresses this issue. A comprehensive numerical analysis using a developed simple analytical model in the form of a Lévy-type solution based on Reissner theory has been carried out. The presented model is able to account for different degrees of rotational restraint in plates with two opposite edges simply supported and the other two partially clamped by introducing the fixity factor. The obtained results are compared with those available in the literature, as well as with a numerical FEM model, whereby good agreement is observed. The significant difference when using the proposed model to analyze a thick plate, as opposed to the models based on Kirchhoff theory, is underlined.