In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model. POF in rats was induced by intraperitoneal injection of 200 mg/kg cyclophosphamide on day 1 and then 8 mg/kg/day for the following 14 days. After 14 days of cyclophosphamide administration, rats were randomly divided into three groups as follows (n = 10/group): POF, POF + CRC (100 mg/kg/day), and POF + CPS (0.5 mg/kg/day) to determine the effects of CRC and CPS on the cyclophosphamide-induced POF rat model. Biochemical, hormonal, and histopathological evaluations were performed on blood and tissue samples 14 days after the CRC and CPS treatments. Malonaldehyde levels were significantly reduced, and glutathione levels and superoxide dismutase activity were significantly increased, in ovarian tissues in the POF + CRC and POF + CPS groups compared with the POF group. In the POF group, we observed hemorrhage and prominent mononuclear cell infiltration beneath the germinative epithelium, vascular congestion in ovarian stroma, hemorrhage around the corpus luteum, and atresia in ovarian follicles. This histopathological damage was significantly improved by treatment with CRC and CPS. There was a significant reduction in serum follicle-stimulating hormone and luteinizing hormone levels in rats treated with CRC and CPS compared with the POF group. Moreover, the levels of estradiol and anti-mullerian hormone in rats treated with CRC and CPS were significantly increased compared with the control group. In conclusion, CRC and CPS treatment of rats with cyclophosphamide-induced POF had a beneficial effect on reducing ovarian damage by improving tissue oxidative stress marker levels, ovarian reserve marker levels, and histopathological parameters. The significant improvements in ovarian tissue histopathological damage and hormonal levels detected in this study indicate that treatment with CRC or CPS might be a conservative treatment approach for cyclophosphamide-induced POF.

Natural disasters, such as earthquakes, have significant psychological consequences, particularly for vulnerable populations like postpartum women. This study aimed to determine the relationship between perceived social support and mental health among postpartum women who had experienced an earthquake. In this comparative cross-sectional study, the case group ( n = 62) consisted of women who were in their third trimester at the time of the earthquake and gave birth after the disaster, while the control group ( n = 62) comprised women who were also in their third trimester during the earthquake and had given birth but were not residing in the earthquake-affected region and had no prior experience of an earthquake. The study did not include individuals with intellectual disabilities, illiteracy. Data were collected using the Sociodemographic data form, the Edinburgh Postnatal Depression Scale, the Multidimensional Scale of Perceived Social Support (MSPSS), the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), and the Post-Traumatic Growth Inventory (PTGI). The incidence rates of Posttraumatic Stress Disorder (40.3%) and Postpartum depression (43.5%) in postpartum women who experienced the earthquake were significantly higher than those in women who did not (Posttraumatic stress disorder: 6.5%, Postpartum depression: 16.1%) (respectively, p <.001; p  =.001). The mean total MSPSS score of postpartum women who experienced the earthquake (61.7 ± 16.9) was significantly higher than that of those who did not (51.9 ± 13.2) ( p <.001). The mean PTGI total score in postpartum women who experienced the earthquake (69.0 ± 19.2) was significantly higher than in the control group (57.3 ± 20.0) ( p  =.001). In postpartum women who experienced the earthquake, there was a significant positive correlation between PTGI and MSPSS scores, and between PCL-5 and Edinburgh Postnatal Depression Scale scores ( p <.001). Pregnant women who experienced the earthquake had significantly higher posttraumatic stress disorder and postpartum depression scores compared to those who did not. It was concluded that perceived social support may promote posttraumatic growth in women who have experienced a postpartum earthquake.

Objective Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy that frequently leads to hospitalization and significant maternal morbidity. Despite its clinical significance, the pathogenesis of HG remains poorly understood, with systemic inflammation emerging as a possible contributing factor. The aim of this study was to investigate the role of novel inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV), in the pathophysiology of HG and their association with disease severity. Materials and methods This retrospective case–control study included 259 pregnant women (159 with HG and 100 healthy controls) enrolled in Inonu University School of Medicine between January 2020 and August 2023. Hematologic parameters, including leukocyte, neutrophil, lymphocyte, and platelet counts and ketonuria levels, were collected from electronic medical records. Inflammatory indices (NLR, PLR, SII, and PIV) were calculated and their diagnostic performance was evaluated using receiver-operating characteristic (ROC) curve analysis. Logistic regression was used to assess the risk factors for HG. Statistical analyses were performed using SPSS version 22, with p < 0.05 considered significant. Results The HG group had significantly higher NLR (p = 0.004), PLR (p = 0.003), SII (p < 0.001), and PIV (p < 0.001) compared to controls. ROC analysis revealed that NLR [cut-off: 5.67, area under the curve (AUC) 0.608, 95% confidence interval (CI) 0.545–0.668, p = 0.002], PLR (cut-off: 154.5, AUC 0.610, 95% CI 0.547–0.669, p = 0.002), SII (cut-off: 948.4, AUC: 0.636, 95% CI 0.575–0.695, p < 0.001), and PIV (cut-off: 866.51, AUC 0.637, 95% CI 0.575–0.696, p < 0.001) showed moderate diagnostic performance with high specificity (70–94%) but variable sensitivity (25.8–55.3%). Logistic regression identified low gestational age and increased platelet distribution width (PDW) as significant risk factors for HG (p < 0.05), while PIV and other inflammatory markers did not emerge as independent predictors. Conclusion This study emphasizes the role of systemic inflammation in HG as evidenced by increased inflammatory indices in HG patients. NLR, PLR, SII, and PIV prove to be promising diagnostic markers for HG and offer high specificity and sensitivity. However, their lack of correlation with ketonuria suggests that inflammation alone cannot fully explain the severity of the disease. These findings highlight the need for further research to validate these markers and explore their potential for the development of personalized treatment strategies for HG.