Urinary tract infections (UTIs) rank among the most common bacterial infections globally, impacting around 404 million individuals each year. This research investigates trends in mortality associated with UTIs in adult patients across the United States from 1999 to 2023. We retrospectively examined death statistics from the CDC WONDER database, examining mortality trends where UTI was the primary or contributing cause. Age-adjusted mortality rates (AAMR) per 1,00,000 were computed and categorized by sex, race/ethnicity, urbanization, state, and census region. Trends were evaluated using joinpoint regression to determine annual percentage change (APC) with 95% confidence intervals. From 1999 to 2023, there were a total of 10,83,913 UTI-related deaths among individuals aged 25 and older. The overall AAMR decreased from 1999 to 2018 (APC: −0.80; 95% CI: −1.13 to −0.46), followed by a significant increase up to 2023 (APC: 3.95; 95% CI: 1.60–6.36). Females consistently displayed higher AAMRs compared to males. Non-Hispanic (NH) American Indian/Alaskan Native individuals experienced the highest (AAMR) among racial groups. In terms of geography, nonmetropolitan areas exhibited higher rates than metropolitan regions, while the South reported the highest AAMR when considering census regions. Tennessee had the highest AAMR (30.48) between 1999 and 2020. Mortality related to UTIs has been on the rise since 2018, with the most notable rates found among females, NH American Indian/Alaskan Native, nonmetropolitan residents, and those in the Southern region. These disparities emphasize the necessity for ongoing initiatives and targeted interventions aimed at these high-risk groups.

Background/Objectives: Drowning is a leading preventable cause of unintentional injury death, yet U.S. prevention efforts have largely focused on children. Despite international declines in pediatric drowning mortality, adult trends remain poorly characterized. We examined long-term trends and disparities in unintentional drowning mortality among U.S. adults aged ≥25 years from 1999 to 2024. Methods: Using CDC WONDER Multiple Cause of Death data, drowning deaths were identified using ICD-10 codes W65–W74, V90, and V92. Age-adjusted mortality rates (AAMRs) per 100,000 were computed by direct standardization to the 2000 U.S. standard population. Joinpoint regression estimated the annual percent change (APC) and average annual percent change (AAPC). Three sensitivity analyses assessed transport-related code exclusion, pandemic-era restriction, and multiple cause-of-death coding. Results: During 1999–2024, 101,743 unintentional drowning deaths occurred among U.S. adults aged ≥25 years (76,554 males; 25,201 females), with 58.09% in natural water or outdoor settings. The overall AAMR showed a non-significant increase (AAPC: 0.55%, p = 0.054); however, joinpoint analysis identified stable rates through 2013 followed by a significant sustained increase (APC: 1.32%, 95% CI: 0.32–2.32, p = 0.012). The male-to-female rate ratio narrowed significantly from 4.00 (1999) to 3.32 (2024) (ratio of rate ratios: 0.83, p = 0.0006), driven by a sustained female increase (AAPC: 1.27%, p < 0.001). Adults aged 65–85+ showed the steepest rise (AAPC: 1.15%, p < 0.001). Non-Hispanic AI/AN adults had the highest rates (3.47–5.44 per 100,000), and non-metropolitan areas consistently exceeded metropolitan rates. Conclusions: A significant upward trajectory has persisted since 2013, with marked disparities by age, sex, race/ethnicity, and geography. Adult-focused, equity-driven prevention strategies aligned with USNWSAP implementation are needed to address this underrecognized burden.

Stroke and malnutrition remain significant contributors to preventable mortality in the United States. Stroke is a leading cause of death and disability, while malnutrition, often underrecognized, exacerbates neurological and systemic vulnerability. Characterizing long-term national and subgroup-specific mortality patterns is critical for guiding public health interventions. Mortality data for stroke and malnutrition were analyzed from 1999 to 2023 using the Centers for Disease Control and Prevention's Wide Ranging Online Data for Epidemiologic Research (CDC WONDER) database. Age-adjusted mortality rates (AAMR) per 1,000,000 population were calculated and stratified by sex, race/ethnicity, census region, state and urbanization status. Joinpoint regression estimated average annual percent change (AAPC) with 95% confidence intervals (CIs). From 1999 to 2023, 44,368 deaths were attributed to malnutrition and stroke. The overall AAMR rose from 12.11 in 1999 to 14.75 in 2023, with an overall AAPC of 0.88% (95% CI: -0.14 to 1.91). Males had higher AAMRs than females. By race, Non Hispanic (NH) Black experienced the greatest AAMRs, whereas NH Asian had the lowest rates. Regionally, the South showed the highest rate, whereas Northeast had the lowest. Nonmetropolitan areas exceeded metropolitan areas. At the state level, the highest rates were observed in South Dakota and Arkansas, while Massachusetts recorded the lowest rates. From 1999 to 2023, combined mortality from stroke and malnutrition increased modestly nationwide, with enduring disparities across demographics and geography. The highest burdens fell on NH Black individuals, people living in the South and nonmetropolitan areas, and certain central states. These findings highlight the need for region-specific prevention and better access to nutritional and neurological care.

Colorectal carcinoma (CRC) remains a major cause of cancer mortality in the United States (U.S.); however, contemporary long-term projections by demographic and geographic strata are limited. This study examined national colorectal cancer mortality trends from 1999 to 2025 and projected age-adjusted mortality rates (AAMRs) through 2050. We conducted an ecological time-series analysis of U.S. adults aged ≥ 25 years using Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research Multiple Cause of Death data. CRC-related deaths were identified by any mention of International Classification of Diseases, Tenth Revision codes C18–C20 on the death certificate. AAMRs per 100,000 population were calculated overall and stratified by sex, age group, race and ethnicity, urbanization, census region, state, and place of death. Joinpoint regression was used to estimate the annual percent change and average annual percent change. A demographically optimized ensemble forecasting model was used to project AAMRs from 2026 to 2050. From 1999 to 2025, 1,674,393 CRC-related deaths were recorded. Overall, the AAMR declined from 38.11 in 1999 to 23.14 in 2025 (average annual percent change, −1.99%; 95% confidence interval, −2.13 to −1.85; P < .001), but recent rates have stabilized. The mean AAMR was higher among men than women (34.13 vs 23.43) and higher in nonmetropolitan than metropolitan areas (32.43 vs 28.49). Non-Hispanic Black adults had the highest racial and ethnic burdens (37.45). Adults aged 25 to 44 years showed a significant increase in mortality (annual percent change, 1.13%; 95% confidence interval, 0.93 to 1.33; P < .001). Most deaths occurred at home (41.15% of deaths). The overall AAMR was projected to continue declining slowly, from 23.02 in 2026 to 21.56 in 2050, at a slower pace than the 1999 to 2016 decline. U.S. CRC mortality has declined substantially and is projected to continue declining slowly through 2050, rather than resume its earlier faster decline, with persistent sex, racial, rural, age, and geographic disparities. Targeted strategies are needed to improve screening completion, diagnostic follow-up, rural access, equity, and early-onset colorectal cancer detection.