Background: Parkinson’s disease and dementia are major neurodegenerative disorders that substantially contribute to disability, dependency, and mortality worldwide. Although prior CDC WONDER studies have separately evaluated Parkinson’s disease and dementia mortality trends, fewer analyses have examined national mortality patterns in which both conditions are recorded on death certificates simultaneously over extended time periods. Methods: We analyzed U.S. death certificates from 1999 through 2025 using the CDC WONDER Multiple Cause of Death database, identifying deaths among adults aged ≥45 years in which both Parkinson’s disease (ICD-10 G20) and dementia-related codes (F01, F03, G30, G31) were recorded anywhere on the certificate. This operational definition captures co-recorded diagnoses and does not identify clinically confirmed Parkinson’s disease dementia. Age-adjusted mortality rates (AAMRs) per 100,000 were standardized to the 2000 U.S. standard population, a method that controls for shifts in population age structure over time and allows valid temporal comparisons independent of absolute population growth. Joinpoint regression was used to quantify trends. Sensitivity analyses excluded 2025 provisional data and the COVID-19 period (1999–2019). Results: A total of 337,721 deaths were identified. Overall AAMR increased from 5.75 (95% CI: 5.60–5.90) in 1999 to 11.15 (95% CI: 10.98–11.32) in 2025 (AAPC: 2.07; p = 0.002). A sharp transient increase occurred in 2020, attributable to pandemic-related factors including disproportionate COVID-19 mortality among older adults with neurodegenerative conditions, care disruptions, and changes in death-certificate coding practices. Following this pandemic-era peak, AAMRs declined significantly through 2025 and should be interpreted cautiously given provisional data. Males (AAPC: 2.14), non-Hispanic White individuals (AAPC: 2.29), the Midwest region (AAPC: 2.65), and non-metropolitan areas carried the highest mortality burden. Mortality was greatest among adults aged ≥85 years. Conclusion: Population-level death rates involving co-recorded Parkinson’s disease and dementia demonstrated significant temporal changes over the study period, with marked demographic and geographic disparities. These findings reflect death-certificate surveillance data and cannot establish clinical co-occurrence, causal relationships, or individual disease risk.

Urinary tract infections (UTIs) rank among the most common bacterial infections globally, impacting around 404 million individuals each year. This research investigates trends in mortality associated with UTIs in adult patients across the United States from 1999 to 2023. We retrospectively examined death statistics from the CDC WONDER database, examining mortality trends where UTI was the primary or contributing cause. Age-adjusted mortality rates (AAMR) per 1,00,000 were computed and categorized by sex, race/ethnicity, urbanization, state, and census region. Trends were evaluated using joinpoint regression to determine annual percentage change (APC) with 95% confidence intervals. From 1999 to 2023, there were a total of 10,83,913 UTI-related deaths among individuals aged 25 and older. The overall AAMR decreased from 1999 to 2018 (APC: −0.80; 95% CI: −1.13 to −0.46), followed by a significant increase up to 2023 (APC: 3.95; 95% CI: 1.60–6.36). Females consistently displayed higher AAMRs compared to males. Non-Hispanic (NH) American Indian/Alaskan Native individuals experienced the highest (AAMR) among racial groups. In terms of geography, nonmetropolitan areas exhibited higher rates than metropolitan regions, while the South reported the highest AAMR when considering census regions. Tennessee had the highest AAMR (30.48) between 1999 and 2020. Mortality related to UTIs has been on the rise since 2018, with the most notable rates found among females, NH American Indian/Alaskan Native, nonmetropolitan residents, and those in the Southern region. These disparities emphasize the necessity for ongoing initiatives and targeted interventions aimed at these high-risk groups.

Syphilis-related mortality in the United States remains incompletely characterized in the post-pandemic period. This study aimed to quantify trends, demogr