Objective: The aim of the present study was to investigate the biochemical and histopathological impact of ozone treatment in an experimental model of osteomyelitis in rats. Methods: A total of 24 adult male Sprague-Dawley rats (3 months old, each weighing 300 to 400 g) were randomly allocated into three groups. Group I (n=8) served as a control and received no interventions or medications. In Group II (n=8), osteomyelitis was induced in the femur and no treatment was applied. Group III (n=8) received intraperitoneal ozone treatment for 3 weeks after the formation of osteomyelitis in the femur. Serum samples were taken to assess total antioxidant capacity (TAC), protein carbonyl content (PCO), and lactate dehydrogenase (LDH). Bone specimens obtained from the femur were histopathologically evaluated for inflammation, necrosis, osteomyelitis, and abscess formation. Results: Serum TAC levels were notably higher (p<0.001), while LDH levels were lower (p=0.002) in Group III than Group II. No significant difference was detected between groups with respect to PCO level. Similarly, Group III displayed more favorable histopathological outcomes with respect to osteomyelitis (p=0.008), inflammation (p=0.001), necrosis (p=0.022), and abscess formation (p=0.022). Conclusion: Ozone may be a useful adjunct treatment for osteomyelitis. Further studies in animals and humans are needed to clarify and confirm these preventive effects, understand the underlying pathophysiology, and establish guidelines. Level of Evidence II; Prospective comparative study.

BackgroundThe use of generative large language models (LLMs) in healthcare is rapidly increasing, offering easier access to medical information. However, comprehensive data on their multilingual accuracy and the reliability of cited scientific references remain limited. This study aimed to compare the response accuracy and reference quality of three free LLMs (ChatGPT, Google Gemini, DeepSeek) in Turkish and English using common pregnancy-related questions.MethodsIn this comparative observational study, 14 frequently asked pregnancy questions were posed to each LLM in Turkish and English, requesting responses supported by up-to-date scientific web sources. Answers were evaluated blindly by obstetricians and gynaecologists for accuracy. References were independently assessed for reliability, scientific validity, and accessibility. Statistical analyses were performed.ResultsLanguage and model infrastructure significantly influenced performance. Google Gemini and DeepSeek provided more accurate responses in English than in Turkish (p

Background/Objectives: This study aimed to evaluate the association between the clinical parameters of vaginal infection—specifically the presence, type, number of concurrent symptoms, and recurrence frequency—and cervical cytology findings, including inflammation severity, Candida, bacterial vaginosis, cellular abnormalities, and Human Papillomavirus (HPV) positivity. Methods: This prospective, cross-sectional, observational study included 458 women attending our gynecology outpatient clinic for Pap smear screening. Vaginal symptoms were documented through face-to-face interviews using a structured data collection form. Cervical samples were evaluated via liquid-based cytology by a single, experienced cytopathologist, who was blinded to the clinical data; cellular abnormalities, the degree of inflammation and cytomorphological findings indicative of infection were reported. HPV analysis was performed on the 218 women for whom results were available. Chi-square and trend chi-square tests were used in the statistical analysis. Results: No significant association was found between the clinical parameters of vaginal symptoms—specifically presence, concurrency, and recurrence frequency—and cytological abnormalities, HPV positivity and bacterial vaginosis (p > 0.05). In contrast, the prevalence of moderate-to-severe inflammation was significantly higher in women with vaginal discharge and a greater symptom burden (p < 0.05). Pruritus, dysuria, and vaginal burning were significantly associated with Candida positivity (p < 0.05). However, no significant association was found between the severity of cervical inflammation and abnormal cytology or HPV positivity (p > 0.05). In multivariable logistic regression analyses, neither symptom burden nor cervical inflammation severity was independently associated with abnormal cytology or HPV positivity. Conclusions: Our findings indicate that vaginal symptoms and the severity of cervical inflammation may not serve as definitive or independent discriminatory markers for cellular abnormalities or HPV positivity in this context. Nevertheless, specific symptom patterns may assist clinicians in evaluating localized infectious processes. Consequently, while standard cytological and molecular protocols remain essential for oncogenic screening, evaluating the overall symptom burden provides clinicians with a valuable framework for identifying benign dysbiotic and inflammatory processes. These findings remained consistent after adjustment for major clinical confounders.

Amaç: Antenatal dönemde yenidoğanda ortaya çıkan fiziksel yaralanmalar “doğum travması” olarak belirtilmektedir. Klavikula kırıkları yenidoğanlarda kemiğe bağlı en sık görülen doğum travmasıdır. Çalışmamızda yenidoğan muayenesinde klavikula kırığı saptanan olguların değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Hastanemizde 1 Ocak 2022 ile 1 Ağustos 2024 tarihleri arasında doğan bebeklerin dosyaları retrospektif olarak incelendi. Çalışmamızda belirtilen 2,5 yıllık zaman aralığında hastanemizde doğum sayısının 2756 olduğu (2022:1185,2023:1044,2024:527) tespit edildi. Bu doğumların içerisinde klavikula kırığı tespit edilen 31 yenidoğan hasta çalışmaya dahil edildi. Bulgular: Toplam doğumların %42,6’sı normal spontan vajinal yol ile olurken %57,4’ünün sezaryen yöntemi ile olduğu tespit edildi. Çalışmamızda olguların kız/erkek oranı 13/18 idi. Olguların anne yaşı ortalaması 26,64 ± 4,61 gebelik haftası ortalaması 39,08 ± 1,04 idi. Doğum şekli değerlendirildiğinde normal vajinal doğum ile doğan 29 (%93,5), sezaryen ile doğan 2 (%6,5) olgu saptandı. Çalışmamızda doğum tartısı en az olan olgu 2770 gr iken en fazla doğum tartısına sahip olgu 4640 gr’dı. Olguların doğum ağırlığı ortalaması 3462,25 ± 453,11 gr saptandı. Klavikula kırığı saptanan olgularımızın %93,5’i (n:29) vajinal yol ile dünyaya gelirken, %6,5 ‘inin (n:2) ise sezaryen ile doğduğu saptandı. Sonuç: Çalışmamızda tüm doğumların %1,1’inde klavikula kırığı saptandı. Ayrıntılı yenidoğan muayenesinde klavikula kırığı şüphesi olan hastalarda direk grafi ile tanı konmaktadır. Genellikle konservatif yaklaşım ile sekelsiz iyileşme olmaktadır. Doğum travmasının şiddetine bağlı gelişen sinir hasarı varlığında uzun dönem takip ve komplikasyonlar görülebilmektedir.

Background: This study aimed to evaluate the phenotype-specific profiles of serum Isthmin-1 (ISM-1), Trimethylamine N-Oxide (TMAO) and Nitric Oxide (NO) levels in women diagnosed with Polyendocrine Metabolic Ovarian Syndrome (PMOS, formerly known as Polycystic Ovary Syndrome—PCOS) according to the Rotterdam criteria. Methods: This cross-sectional study enrolled 90 reproductive-aged women, divided equally into five groups (n = 18 per group) with similar baseline metabolic parameters: healthy controls and PMOS Phenotypes A, B, C, and D. To minimize confounding effects, individuals with recent use of specific medications were excluded, and 24 h dietary recalls were obtained. Fasting blood samples were collected during the early follicular phase. Serum ISM-1, TMAO, and NO levels were quantified via ELISA, and insulin resistance was determined using the HOMA-IR index. Data were adjusted for potential confounders, including age, BMI, and smoking status, using multivariate linear regression models. Results: No statistically significant differences were observed between the groups in key parameters such as BMI and HOMA-IR. Serum ISM-1 levels did not show a significant difference between the groups (p = 0.501). In contrast, NO levels were found to be significantly lower in all PMOS phenotypes compared to the control group (p < 0.001), and this reduction remained independent in regression models. TMAO levels, however, exhibited a phenotype-specific distribution; in the non-hyperandrogenic Phenotype D, they were found to be significantly lower than in the control group and hyperandrogenic phenotypes A and B. In the multivariate regression analysis, it was confirmed that Phenotype D was independently associated with low TMAO levels (B = −0.131, p = 0.027). Conclusions: Although PMOS patients share a similar profile of obesity and insulin resistance, they exhibit marked biochemical heterogeneity. Whilst the reduction in NO levels may indicate a generalised vascular change affecting all phenotypes, the observation of low TMAO levels specifically in the non-hyperandrogenic Phenotype D highlights a distinct biochemical signature associated with this subgroup, observed in the absence of hyperandrogenism. Our findings support the notion that adopting phenotype-specific, individualised approaches in the management of PMOS may be beneficial.

Maksiller sinüs doğumda bulunan bilateral en büyük paranazal sinüslerdir. Bu çalışmada retrospektif olarak kranial Magnetik Rezonans Görüntüleme (MRG) sonrası, maksiller sinüs varyasyon sıklığını, patolojilerini ve morfometrik ölçümlerini saptamak, varyasyonların maksiller sinüslerdeki enflamatuar sinüs hastalıklarına predispozisyon oluşturup oluşturmadığının değerlendirilmesi amaçlandı. Çalışmada hastalarda MRG’de; maksiller sinüs’ün coronal kesitte: longitudinal, transvers, sert damağa (MSOH) ve concha nasalis inferior’a (MSOIT) olan uzaklık ölçümleri ve sagittal kesitte; antero-posterior uzunluğu ölçüldü. Maksiller sinüzit tanılı hastalar akut maksiller sinüzit (Grup 1) ve kronik maksiller sinüzit (Grup 2) olarak iki gruba ayrıldı. İstatistiksel analiz SPSS version16 (IBM Corporation) kullanılarak student t testi ile yapıldı. Çalışmada 105 hastanın 50'si (%47,6) erkek, 55’i (%52,4) kız hasta idi. Hastaların yaş ortalaması Grup 1 için 8,1, Grup 2 için 13,3 idi. Grup 1’de 13 hastada, Grup 2’de 22 hastada olmak üzere toplamda 35 (%33,3) hastada en az bir maksiller sinüs anatomik varyasyonu saptandı. Hastaların MRG ile her iki grubun sağ ve sol maksiller sinüs anatomik ölçümlerinin karşılaştırma değerlendirmesinde transvers sol-sağ dışında diğer anatomik ölçümlerde istatiksel olarak anlamlı farklılık bulunmadı. Grup 1’de; MSOH sol-sağ ve MSO sol-sağ ölçüm değerlendirmesinde her iki parametrede sol maksiller sinüs ölçümleri daha uzun olup, istatiksel olarak anlamlı bir fark tespit edildi (p