Gastrointestinal sistemin en sık epitelyal olmayan benign tümörü olan lipom kolonda nadir olarak görülür. Bu yazıda karın ağrısı şikayeti olan 55 yaşında erkek hastada kolonoskopide çıkan kolonda lümeni tıkayan polipoid kitle sunulmaktadır. Olgu yapılan histolojik incelemede submukozal lipom tanısı almıştır.

Background/Objectives: Non-small-cell lung carcinoma (NSCLC) accounts for approximately 85% of lung cancers and remains a leading cause of cancer-related mortality. Although cisplatin is a cornerstone chemotherapeutic agent, its clinical effectiveness is limited by drug resistance and systemic toxicity. Capsaicin (CAP), a bioactive phytochemical derived from chili peppers, has demonstrated anticancer activity in several tumor types and has been investigated as a potential adjunct to conventional chemotherapy. Methods: An experimental study was conducted using A549 NSCLC cells and a xenograft mouse model. Cells were treated with CAP (50–300 µM), cisplatin (1 µg/mL), or their combination. Cell proliferation and apoptosis were evaluated using sulforhodamine B (SRB) assay, immunocytochemistry, and Western blot analysis. In vivo, tumor growth inhibition, histopathological alterations, and immunohistochemical expression of Ki-67 and cleaved caspase-3 were assessed. Results: Low CAP concentrations (50–100 µM) slightly increased proliferation, whereas concentrations ≥ 150 µM significantly reduced cell viability and induced apoptosis. Cisplatin monotherapy markedly suppressed proliferation and activated apoptosis. Bliss independence analysis demonstrated concentration-dependent synergy between CAP and cisplatin, with maximal synergy scores reaching 28.1 at 100 µM CAP. Combination treatment at CAP concentrations ≥ 150 µM produced the strongest antiproliferative effect in vitro and the highest tumor growth inhibition in vivo (88%). CAP did not further enhance cisplatin-induced apoptosis but significantly reinforced proliferation suppression with reduced Ki-67 expression. Conclusions: CAP exhibits biphasic dose-dependent effects in NSCLC and enhances cisplatin antitumor efficacy predominantly through proliferation suppression, supporting its further evaluation as an adjunctive phytochemical in cisplatin-based NSCLC therapy.

Ksantogranülomatöz inflamasyon, etkilediği organın normal dokusunu yıkıma uğratan kronik inflamasyonun nadir bir formudur. En sık böbrekte ve safra kesesinde karşılaşılan bu inflamasyon, fallop tüplerinde çok ender olarak bildirilmiştir. Kitlesel lezyon olarak ortaya çıkarak maligniteyi taklit etmesi ve ayrıca sistemik inflamasyona ilerleyerek ölümle sonuçlanabilmesi klinikte oldukça önemlidir. Ksantogranülomatöz salpenjit tanısı alan 2 ayrı olgu klinik ve patolojik özellikleri ile birlikte sunuldu.