The presented case-control study was developed to characterize the clinical, histopathological and immunological profile of patients with traumatic injuries, benign neoplasms, potentially malignant oral disorders and malignant neoplasms of the oral cavity, in order to identify biomarkers of malignancy.

Considering the importance of tumor microenvironment characterization, this study aims to determine the immunoexpression of PD-L1 and correlate with the frequency of CD4+ and CD8+ cells in AC and LLSCC lesions and with tumor-infiltrating lymphocytes (TILs) in LLSCC and its relationship with histopathological characteristics. This sample includes 33 cases of AC and 17 cases of LLSCC. The cases were submitted to histopathological analysis and to CD4+, CD8+, and PD-L1+ cell determination by immunohistochemistry. There was a significant difference among the frequencies of CD4+, CD8+, and PD-L1+ cells between AC and LSCC cases, higher in the last group. Moreover, histopathological and atypical changes in AC and LLSCC were correlated with the frequencies of PD-L1+, CD4+, and CD8+ cells. In AC, PD-L1+ cases had a low frequency of CD4+ cells, but on the other hand, PD-L1+ cases of LLSCC had a higher frequency of CD4+ and CD8+ cells. Therefore, the PD-L1 molecule may be a potential escape route for the immune response in oral lesions, but the mechanisms differ between AC and LLSCC. Future studies related to immune evasion and immunotherapy in oral lesions should consider the analysis of inflammatory infiltrate and TILs.

Background: The time elapsed since HIV infection diagnosis (TdiagHIV) affects the quality of life (QoL) and can get worse when chronic illnesses start. Objective: The aim of this study was to analyze the impact of metabolic syndrome (MetS) and cardiovascular risk (CVR) on the QoL of people living with HIV (PLHIV). Methods: Cross-sectional study, with 60 PLHIV followed at a Reference Center in the city of Jataí, Goiás, Brazil. Data collection involved sociodemographic, clinical, CVR, MetS, and QoL information. The data were analyzed using descriptive and inferential statistics, with the BioEstat 5.3 program adopting p0.05. Results: There was a predominance of men (61.7%), aged ≥38 years (53.3%), with a TdiagHIV of 97.88Añ85.65 months and use of antiretroviral therapy (ART) of 80.13Añ69.37 months. The worst domain of QoL was concern about confidentiality (40 points), and the best was medication concerns (95 points). MetS predominated at 18.3% and a moderate CVR at 11.7%. MetS was positively associated with age 38 years, the female sex, with the lowest score in QoL for general function, and the highest for TdiagHIV and the use of ART (p0.05). A moderate CRV was positively related to higher TdiagHIV and ART use, and low HDL-c, and the lowest score for QoL was found for trust in a professional (p0.05). Conclusion: PLHIV who are older, have a higher TdiagHIV, and use ART are more likely to develop MetS and moderate CVR. The presence of these diseases in PLHIV causes impairment in areas of QoL.

To conduct a serological screening for toxoplasmosis in the heel prick test and to evaluate its epidemiological aspects in newborns and postpartum women in Jataí, Goiás.

Introdução: Com o advento dos antirretrovirais, pessoas vivendo com HIV (PVHIV) aumentaram sua expectativa de vida e, por outro lado, desenvolveram mais comorbidades, como a síndrome metabólica (SM) e o aumento do risco cardiovascular (RCV) que podem impactar na qualidade de vida (QV). Objetivo: Analisar a relação da QV com o RCV e a SM em PVHIV. Método: O estudo é uma revisão integrativa segundo as orientações do Systematic Reviews and Meta-Analyses. A busca de manuscritos foi realizada em cinco bases de dados, sem controle de tempo e idioma. Os achados foram exportados para a plataforma Rayyan, onde se excluíram as duplicatas e aqueles cujo tema central não se relacionavam com o assunto. Posteriormente, realizada a leitura na íntegra do artigo para verificar sua inclusão na revisão. Resultados: Foram exportados para o sistema Rayyan 995 artigos, dos quais 981 foram excluídos por duplicata, título ou resumo. Posteriormente, 14 estudos foram avaliados na íntegra pelos pesquisadores, os quais não incluíram nenhum artigo na revisão, pois não se enquadraram nos critérios de elegibilidade. Conclusão: A carência de estudos que avaliaram a relação da QV com a SM e o RCV em PVHIV não permite fazer inferências diretas. Contudo, postula-se uma diminuição da QV associada as comorbidades ligadas a SM e ao RCV nas PVHIV.

Realizar a triagem sorológica da toxoplasmose no teste do pezinho e avaliar os aspectos epidemiológicos em recém-nascidos e puérperas de Jataí, Goiás.