By NURULLAH YÜCEL, MUZAFFER ŞEKER, MEHMET TUĞRUL YILMAZ, et al., Published on 01/01/22

Quality cardiopulmonary resuscitation (CPR) is associated with improved survival rates in prehospital arrest cases. Although CPR guidelines emphasize compression depth, rate, and recoil, individual anatomical and biomechanical factors influencing CPR performance remain underexplored. This study aims to determine the optimal CPR position by focusing on individual positional conditions and anthropometric data to improve CPR effectiveness and guide team member selection in emergency scenarios. A cross-sectional study involving 123 paramedic associate degree students was conducted. Anthropometric measurements including upper extremity length, biceps circumference, and femur length were obtained. CPR performance was assessed using a feedback-capable mannequin, with data collected on compression depth, frequency, rhythm quality, and compression/decompression ratios. Positional parameters such as knee and hip angles, distance between knees, and distance from the mannequin were recorded and analyzed in relation to CPR outcomes. Male participants demonstrated significantly higher CPR quality scores than females (65.09 ± 28.26 vs. 48.85 ± 27.11, p = 0.004). Positive correlations were found between BMI (r = 0.239, p = 0.008), upper extremity length (r = 0.364, p < 0.001), biceps circumference (r = 0.350, p < 0.001), and CPR quality metrics. A moderate inter-knee position (shoulder-width distance) provided superior compression depth and rhythm stability compared to narrow or wide positions (p < 0.001). Anthropometric and positional factors significantly influence CPR performance. Emergency team members with appropriate physical profiles (e.g., greater muscle mass, limb length, BMI) and adopting occupational ergonomic factors (e.g., moderate knee range, limited joint flexion) may improve CPR quality in the prehospital setting.

It is very important to try to learn Anatomy within its unique methodology and develop personalized strategies. One of the most important goals of a practitioner who graduates from medical school is to become a specialist physician. For this purpose, different specialization exams are held in different countries. Questions from the Anatomy course have a very important weight in the Medical Specialization Examination (TUS) held in Türkiye. In this article, we evaluate the specialty exam according to current anatomy education literature by revealing the question styles from an anatomist’s perspective in order to learn anatomy more efficiently and develop strategies for tricky points. We analyzed 396 valid Anatomy questions asked in TUS between 2006 and 2021. Among all the questions; According to the systematic anatomy classification, neuroanatomy (35.1%, n = 139) and according to the topographic anatomy classification, head and neck anatomy (41.4%, n = 164) were the subjects where the most frequently asked questions. In recent years, it has become an important trend that clinical anatomy knowledge (p < 0.01) is at the forefront in all exams and that questions with eponyms and visual content (p = 0.044) are included in the exam. We accept that the Anatomy question styles in TUS are created with a method that is up-to-date and in accordance with the literature and requirements.

X-linked intellectual disability (XLID) is a genetically heterogeneous disorder. Currently, 162 genes linked to XLID have been found, but the cause of XLID is still unclear. While the GNAO1 gene is crucial for hypotonia, epilepsy, developmental delay, and movement disorders, the NEXMIF gene, also known as KIAA2022, has associations with XLID, autism, and epilepsy. The subject of the study, a 5-year-old girl has lots of congenital defects, including a cleft palate, anal atresia, hypotonia in her lower limbs, and thumb missing. A variety of eye abnormalities, such as scoliosis, finger malformations, and craniofacial dysmorphism. Radiological tests revealed substantial heart problems, bilateral renal hypoplasia, and brain abnormalities. She met milestones more later than her contemporaries, indicating clear developmental deficits. The NEXMIF and GNAO1 genes both include heterozygous frameshift variants that were discovered through genetic research using next-generation sequencing. The complex and varied clinical signs of XLID are shown in this case. The clinical picture is further complicated by the co-occurrence of mutations in the NEXMIF and GNAO1 genes, which emphasizes the need for an approach to offer suitable therapy solutions. Future studies are necessary to understand the complex interactions between these genes and how they affect XLID and related symptoms.

Psoriasis, an inflammatory autoimmune disease, arises from intricate interactions between the immune system and epithelium. Recent reports have suggested new roles for gamma delta (γδ) T-cells in addition to immune surveillance, however, it remains to be determined whether the mechanisms identified in psoriasis murine models have a similar role in humans. The aim of the present study was to investigate the relationship between IL-17 A mRNA expression levels and γδ T-cell frequency in human psoriatic lesions, and to clarify the potential role of γδ T-cells in psoriasis pathogenesis. The study involved 20 patients diagnosed with psoriasis and 16 control subjects. Expression of the IL-17 A gene was measured in formalin-fixed paraffin-embedded (FFPE) tissues by RT-PCR method. TCRγδ⁺ immunofluorescence staining was performed to measure the distribution of γδ T-cells in the same samples. In psoriatic lesion biopsies, TCRγδ⁺ T-cell percentage was found higher than the control samples. Additionally, psoriasis patients exhibited elevated levels of IL-17 A gene expression. In addition, this study showed a weak negative correlation between the proportion of γδ T-cells and IL-17 A mRNA expression in psoriatic skin samples. A weak negative correlation between IL-17 A mRNA levels and γδ T-cell presence in human psoriasis lesions highlighting the novel effector functions of these cells in psoriasis pathogenesis.