Segment Anything Model (SAM) has demonstrated impressive zero-shot segmentation capabilities across natural image domains, but it struggles to generalize to the unique challenges of remote sensing data, such as complex terrain, multi-scale objects, and temporal dynamics. In this paper, we introduce TASAM, a terrain and temporally-aware extension of SAM designed specifically for high-resolution remote sensing image segmentation. TASAM integrates three lightweight yet effective modules: a terrain-aware adapter that injects elevation priors, a temporal prompt generator that captures land-cover changes over time, and a multi-scale fusion strategy that enhances fine-grained object delineation. Without retraining the SAM backbone, our approach achieves substantial performance gains across three remote sensing benchmarks-LoveDA, iSAID, and WHU-CD-outperforming both zero-shot SAM and task-specific models with minimal computational overhead. Our results highlight the value of domain-adaptive augmentation for foundation models and offer a scalable path toward more robust geospatial segmentation.

Visual Prompt Tuning (VPT) has emerged as a parameter-efficient fine-tuning paradigm for vision transformers, with conventional approaches utilizing dataset-level prompts that remain the same across all input instances. We observe that this strategy results in sub-optimal performance due to high variance in downstream datasets. To address this challenge, we propose Visual Instance-aware Prompt Tuning (ViaPT), which generates instance-aware prompts based on each individual input and fuses them with dataset-level prompts, leveraging Principal Component Analysis (PCA) to retain important prompting information. Moreover, we reveal that VPT-Deep and VPT-Shallow represent two corner cases based on a conceptual understanding, in which they fail to effectively capture instance-specific information, while random dimension reduction on prompts only yields performance between the two extremes. Instead, ViaPT overcomes these limitations by balancing dataset-level and instance-level knowledge, while reducing the amount of learnable parameters compared to VPT-Deep. Extensive experiments across 34 diverse datasets demonstrate that our method consistently outperforms state-of-the-art baselines, establishing a new paradigm for analyzing and optimizing visual prompts for vision transformers.

Financial question answering is often treated as document question answering, although financial evidence is both multimodal and time-dependent. Semantically equivalent facts expressed in narrative text, tables, page images, or Extensible Business Reporting Language (XBRL) should support consistent answers, whereas a disclosure may support a query only after becoming public. We formalise this combination as crossmodal evidence symmetry under a causal temporal boundary and introduce TempFinRAG, a multimodal temporal retrieval-augmented generation (RAG) framework for point-in-time financial question answering. Given a question, company, and as-of date, the framework enforces the information boundary defined by U.S. Securities and Exchange Commission (SEC) filing availability; aligns page layout, text, table structure, and XBRL facts; retrieves time-valid evidence; executes auditable financial calculations; and generates a cited answer. A verifier checks temporal validity, claim support, numerical consistency, and the need to abstain. We further introduce TempFinQA, a point-in-time evaluation protocol built from public filings and XBRL facts, and evaluate the framework on complementary evidence-grounded, numerical, conversational, and multi-table benchmarks. On TempFinQA, TempFinRAG improves answer accuracy from 66.7% to 78.9% over hybrid RAG while reducing temporal evidence leakage from 10.8% to 1.7% and hallucination from 17.3% to 7.9%. Reliable financial question answering therefore requires consistent treatment across evidence representations and deliberately asymmetric access across time.

Accurate prediction of CB2 receptor ligand activity is pivotal for advancing drug discovery targeting this receptor, which is implicated in inflammation, pain management, and neurodegenerative conditions. Although conventional machine learning and deep learning techniques have shown promise, their limited interpretability remains a significant barrier to rational drug design. In this work, we introduce CB2former, a framework that combines a Graph Convolutional Network with a Transformer architecture to predict CB2 receptor ligand activity. By leveraging the Transformer's self attention mechanism alongside the GCN's structural learning capability, CB2former not only enhances predictive performance but also offers insights into the molecular features underlying receptor activity. We benchmark CB2former against diverse baseline models including Random Forest, Support Vector Machine, K Nearest Neighbors, Gradient Boosting, Extreme Gradient Boosting, Multilayer Perceptron, Convolutional Neural Network, and Recurrent Neural Network and demonstrate its superior performance with an R squared of 0.685, an RMSE of 0.675, and an AUC of 0.940. Moreover, attention weight analysis reveals key molecular substructures influencing CB2 receptor activity, underscoring the model's potential as an interpretable AI tool for drug discovery. This ability to pinpoint critical molecular motifs can streamline virtual screening, guide lead optimization, and expedite therapeutic development. Overall, our results showcase the transformative potential of advanced AI approaches exemplified by CB2former in delivering both accurate predictions and actionable molecular insights, thus fostering interdisciplinary collaboration and innovation in drug discovery.