Manuela Poroh

Dr. Manuela Poroh


Research Focus & Metrics

Academic Career Length

1Year (2026-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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2 November 2026 in Medical Sciences
Verified
Journal Article
Open access
PDF file
MPManuela Poroh
Manuela Poroh
CBCalin Buzea
Calin Buzea
NFNorin FORNA
Norin FORNA
PSPaul-Dan Sirbu
Paul-Dan Sirbu
LSLiliana Savin
Liliana Savin
BPBogdan Puha
Bogdan Puha
Background: Performance estimates in medical-imaging artificial intelligence may depend not only on model architecture but also on dataset integrity, label reproducibility, and the complexity of the prediction target. This study evaluated deep learning for extracapsular proximal femoral fracture radiographs within a duplicate-controlled, patient-level framework, comparing performance for fracture detection with prediction of fine-grained archive-derived AO/OTA group labels and quantifying the reproducibility of the historical labels through blinded reader reassessment. Methods: A retrospective single-center image archive was audited for exact and near-duplicate images, postoperative hardware, technical limitations, patient-level overlap, and label inconsistency. The final analytical cohort comprised 516 radiographs from 515 patient groups, including 75 no-fracture radiographs and 441 radiographs carrying locked archive-derived AO/OTA 31-A1, 31-A2, or 31-A3 analytical labels. A compact convolutional neural network, DenseNet121, ResNet50V2, and EfficientNetB0 were evaluated using three repetitions of five-fold stratified group cross-validation. Performance was estimated from averaged out-of-fold probabilities with 2000 patient-group bootstrap resamples. A second orthopedic trauma specialist subsequently performed a blinded reassessment to quantify label reproducibility. Grad-CAM was used for qualitative error analysis. Results: For the prespecified three-class archive-label prediction task, ResNet50V2 achieved the highest balanced accuracy of 0.395 (95% CI, 0.349–0.444), without a statistically significant advantage over DenseNet121. By contrast, for fracture-versus-no-fracture discrimination, EfficientNetB0 achieved a balanced accuracy of 0.890 (95% CI, 0.845–0.931) and a ROC-AUC of 0.964 (95% CI, 0.947–0.978). Blinded reassessment showed 99.8% agreement for fracture presence (Cohen’s κ = 0.992; 95% CI, 0.973–1.000) and 82.2% agreement for AO/OTA 31-A1/A2/A3 assignment (κ = 0.724; 95% CI, 0.666–0.782), with most subtype disagreements occurring between 31-A1 and 31-A2. Grad-CAM maps showed not only activation overlapping the fracture-side proximal femoral region in some cases but also broad or off-target activation. These qualitative findings do not establish that model predictions relied on clinically relevant fracture features. Conclusions: Deep learning showed strong internal discrimination between fracture and no-fracture radiographs within the reconstructed dataset, although systematic differences in archived image dimensions between these categories may have provided non-anatomical discriminative cues; performance in reproducing fine-grained historical AO/OTA group labels remained limited. Although subtype-label reproducibility was imperfect, the exploratory agreement-stratified analysis did not demonstrate systematically poorer classification performance in cases with discordant annotations. Therefore, the observed performance contrast cannot be attributed causally to annotation disagreement. The subtype results quantify performance against historical analytical labels rather than diagnostic accuracy against an adjudicated clinical consensus standard.

7 October 2026 in Medicina
Verified
Journal Article
Open access
PDF file
ISIrina Sîrbu
Irina Sîrbu
APAnca Iuliana Pîslaru
Anca Iuliana Pîslaru
AIAdina Carmen Ilie
Adina Carmen Ilie
RȘRamona Ștefăniu
Ramona Ștefăniu
SASabinne-Marie Albișteanu
Sabinne-Marie Albișteanu
MPManuela Poroh
Manuela Poroh
Background and Objectives: Hip fracture in older adults is associated with high morbidity, and length of hospital stay is the simplest summary of the acute admission. We aimed to identify the clinical factors associated with prolonged hospital stay in older adults admitted with a hip fracture, and to test whether a weighted comorbidity index predicts stay better than a simple count. Materials and Methods: A retrospective cohort of 624 consecutive patients aged 65 years and older with a trochanteric or femoral neck fracture was studied. Length of stay (LOS) was strongly right-skewed (skewness 5.02) and was log-transformed; comparisons used Mann–Whitney and Kruskal–Wallis tests and Spearman correlations, with multivariable models fitted on 487 operated patients with complete data. Postoperative stay was analyzed as a secondary outcome because the preoperative interval forms part of the total stay. Results: Median stay was 10 days (IQR 8–13) and median wait for surgery was 4 days (IQR 2–6), with only 25.2% operated on within 48 h. In-hospital mortality was 5.3%. The number of comorbidities was the only patient characteristic consistently associated with stay (rho = 0.119, p = 0.003; 1.4% per comorbidity, p < 0.001). The Charlson Comorbidity Index (CCI) showed no association in the unweighted, age-adjusted or severity-graded form. Age, sex and admission hemoglobin effects did not survive non-parametric testing. Conclusions: A simple count of active comorbidities was associated with LOS whereas the CCI was not, and the model containing the count fitted modestly better (adjusted R2 0.385 vs. 0.365; index term non-significant). This hypothesis-generating finding suggests that the comorbidity count, which is available on admission, may serve as a pragmatic screening tool for selecting patients for comprehensive geriatric assessment; its use in place of the CCI would require validation in independent cohorts. The preoperative wait remains the dominant modifiable target, although its effect on total stay is largely structural.