Irina Sîrbu

Dr. Irina Sîrbu


Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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17 July 2025 in Nursing Reports
Verified
Journal Article
Open access
PDF file
APAnca Iuliana Pîslaru
Anca Iuliana Pîslaru
ISIrina Sîrbu
Irina Sîrbu
SASabinne-Marie Albișteanu
Sabinne-Marie Albișteanu
RȘRamona Ștefăniu
Ramona Ștefăniu
ATAna-Maria Turcu
Ana-Maria Turcu
AIAdina Carmen Ilie
Adina Carmen Ilie
Hip fractures in elderly patients pose significant clinical challenges, confronting us with high morbidity and mortality rates. A comprehensive geriatric assessment plays an important role in determining prognosis as well as the indication for surgery. Aim: In this study, we aim to (1) assess frailty-based functional status in seniors with hip fractures, (2) evaluate geriatric assessment’s predictive value for postoperative recovery, and (3) analyze 1-year postoperative survival. Material and Methods: This prospective study included 60 senior patients admitted for hip fracture in the Orthopedics Department. Patients were examined using geriatric assessment instruments Mini Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Mini Nutritional Assessment (MNA), and Frailty Groningen Indicator (GFI). We recorded the sex, marital status, number of comorbidities, and number of recommended drugs. Results: In total, 65% of patients were frail pre-surgery; the proportion increased post-surgery to 86.7%; (p = 0.005). Age greater than 80 years and unmarried marital status were associated with higher frailty risk (p = 0.04; p = 0.03). Preoperatively, important predictors of frailty were mild–moderate cognitive impairment (p = 0.017), mild–moderate depression (p = 0.01), and malnutrition (p = 0.04). Postoperatively, only mild–moderate cognitive impairment (p = 0.04) and mild–moderate depression (p = 0.01) proved to be important predictors of frailty. According to the ROC curve, good predictors of postoperative frailty were shown to be preoperative frailty and the degree of polypharmacy and comorbidity. Of all parameters predictive of postoperative frailty, only the number of medications reached statistical significance (p < 0.038). The study identified a 1-year all-cause mortality rate of 42.6% in elderly patients who underwent hip fracture surgery, with a significant association between mortality and preoperative MMSE, GDS, and MNA scores. Conclusions: Complex geriatric assessment of senior patients with hip fracture can stratify postoperative risk and predict 1-year mortality and postoperative functional recovery. Key predictors include cognitive status, depression, malnutrition, and comorbidities. Multidisciplinary care and standardized evaluation are essential for improving outcomes.

7 October 2026 in Medicina
Verified
Journal Article
Open access
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ISIrina Sîrbu
Irina Sîrbu
APAnca Iuliana Pîslaru
Anca Iuliana Pîslaru
AIAdina Carmen Ilie
Adina Carmen Ilie
RȘRamona Ștefăniu
Ramona Ștefăniu
SASabinne-Marie Albișteanu
Sabinne-Marie Albișteanu
MPManuela Poroh
Manuela Poroh
Background and Objectives: Hip fracture in older adults is associated with high morbidity, and length of hospital stay is the simplest summary of the acute admission. We aimed to identify the clinical factors associated with prolonged hospital stay in older adults admitted with a hip fracture, and to test whether a weighted comorbidity index predicts stay better than a simple count. Materials and Methods: A retrospective cohort of 624 consecutive patients aged 65 years and older with a trochanteric or femoral neck fracture was studied. Length of stay (LOS) was strongly right-skewed (skewness 5.02) and was log-transformed; comparisons used Mann–Whitney and Kruskal–Wallis tests and Spearman correlations, with multivariable models fitted on 487 operated patients with complete data. Postoperative stay was analyzed as a secondary outcome because the preoperative interval forms part of the total stay. Results: Median stay was 10 days (IQR 8–13) and median wait for surgery was 4 days (IQR 2–6), with only 25.2% operated on within 48 h. In-hospital mortality was 5.3%. The number of comorbidities was the only patient characteristic consistently associated with stay (rho = 0.119, p = 0.003; 1.4% per comorbidity, p < 0.001). The Charlson Comorbidity Index (CCI) showed no association in the unweighted, age-adjusted or severity-graded form. Age, sex and admission hemoglobin effects did not survive non-parametric testing. Conclusions: A simple count of active comorbidities was associated with LOS whereas the CCI was not, and the model containing the count fitted modestly better (adjusted R2 0.385 vs. 0.365; index term non-significant). This hypothesis-generating finding suggests that the comorbidity count, which is available on admission, may serve as a pragmatic screening tool for selecting patients for comprehensive geriatric assessment; its use in place of the CCI would require validation in independent cohorts. The preoperative wait remains the dominant modifiable target, although its effect on total stay is largely structural.

21 August 2026 in Medical Sciences
Verified
Journal Article
Open access
PDF file
ISIrina Sîrbu
Irina Sîrbu
BDBianca Ana Dmour
Bianca Ana Dmour
ŞTŞtefan Dragoș Tîrnovanu
Ştefan Dragoș Tîrnovanu
BPBogdan Puha
Bogdan Puha
ECEliza Geanina Cogian
Eliza Geanina Cogian
ADAwad Dmour
Awad Dmour
Background: Alcohol-related conditions may influence both injury patterns and in-hospital management in orthopaedic trauma. This study evaluated the clinical characteristics, injury mechanisms, treatment patterns, and hospital outcomes of adults with acute orthopaedic trauma and documented alcohol use, with particular attention to geriatric vulnerability and alcohol withdrawal. Methods: This retrospective single-centre cohort included adults admitted between January 2018 and December 2025 with acute musculoskeletal trauma and an alcohol-related diagnosis during the same hospitalisation. Patients were classified according to their predominant recorded alcohol-related presentation. Geriatric patients, defined as those aged 65 years or older, were compared with younger adults. Injury mechanisms, comorbidities, operative treatment, intensive care unit involvement, hospital length of stay, mortality, and recorded hospitalisation costs were analysed. Results: The final cohort comprised 294 patients, including 87 geriatric patients. Geriatric patients more frequently sustained same-level or low-energy falls than younger adults (46.0% versus 25.6%; Holm-adjusted p = 0.005) and had a higher prevalence of proximal femoral fractures (40.2% versus 21.7%; OR 2.42, 95% CI 1.41 to 4.16). Any recorded ICU involvement was more frequent among geriatric patients, although prolonged ICU stays of 24 h or longer did not differ significantly between age groups. Alcohol withdrawal was documented in 46 patients and was associated with longer hospitalisation and a longer admission-to-surgery interval. In-hospital mortality occurred in 5 of 46 patients with documented withdrawal (10.9%) and 5 of 248 without withdrawal (2.0%; unadjusted OR 5.93, 95% CI 1.64 to 21.37; p = 0.010). Conclusions: Orthopaedic trauma patients with documented alcohol use represent a clinically heterogeneous population. Geriatric patients showed greater vulnerability to low-energy trauma, proximal femoral fracture, comorbidity, and intensive care involvement, while alcohol withdrawal identified patients with a more complex hospital course. Early recognition of withdrawal risk and enhanced inpatient safety measures may improve orthopaedic care. These findings support careful assessment of alcohol-related risk, early recognition of withdrawal, and heightened inpatient safety precautions.