The incorporation of inorganic nanoparticles (NP) into nanofibrous polymeric membranes (NPM) is an attractive approach to developing multifunctional nanocomposites. The purpose of this study was to incorporate titanium dioxide (TiO₂) NP into NPM to enhance the overall properties. Polycaprolactone (PCL) membranes with TiO₂-NP (0.2 wt%) was fabricated by means of the Air-Jet Spinning (AJS) technique. The physicochemical characterization of the PCL-TiO₂-NPM was performed by X-ray powder diffraction (XRD), the morphology was observed under scanning electron microscopy (SEM), and tensile strength and Young’s moduli were evaluated using an INSTRON Universal Testing Machine. In-vitro biocompatibility was evaluated in terms of cell adhesion and cell proliferation using human fetal osteoblasts. The results obtained demonstrated that TiO₂-NP added to the PCL-NPM increases the values of tensile strength and Young’s moduli (p < 0.008 and p < 0.043) with respect to PCL-NPM without TiO₂-NP. XRD exhibited the characteristic peaks of PCL at 21.3° and 23.7° and of TiO₂ at 36°. The SEM micrographs revealed a random distribution with interconnected micropores. Cell adhesion and proliferation increased according to the time of the culture; only after the first period of cell culture was there a significant difference in cell proliferation (p < 0.05). The possible potential application of this PCL-PNM by Air-Jet Spinning (AJS) in tissue engineering could favor bone regeneration due that the addition of TiO₂-NP.

The challenge of three‐dimensional (3D) printing by polymeric extrusion in tissue bioengineering is to control with precision the microarchitecture and porous interconnectivity of scaffolds, as well as search for models that allow and facilitate the development of personalized constructs that meet optimal characteristics for the regeneration of significant bone defects. In this study, anatomically accurate scaffolds were designed and printed to a critical size defect from a microtomography image of the rat calvaria. Different software is used to design a scaffold with exact anatomy. With Ultimaker Cura software, distinct printing parameters were standardized, permitting the printing of different types of pores and graded porosity scaffolds, with exact adaptation to the bone defect, utilizing a commercial 3D printer with a fused deposition modeling technique and compensating for the limitations of the method. The scaffolds were characterized by evaluating their mechanical properties and surface characteristics (pore size and porosity), employing scanning electron microscopy images, verifying that the size and shape of the pores were controlled, and evaluating cell viability and cell distribution on the 3D printed scaffold. Therefore, this work proves that by standardizing the printing parameters, it was possible to print a unique customized scaffold, controlling the shape and size of pores.

Oral cancer holds the sixth position in malignancies worldwide; 90% correspond to oral squamous cell carcinoma (OSCC). Diverse reports suggest that NTRK genes and their receptors are key oncogenesis regulators to tumor progression in human cancers. Objective: To analyze the NTRK and Trk expression and their association with clinicopathological features of OSCC in Mexican patients’ samples. Material and Methods: We analyzed 95 OSCC cases of pan-trk immunoexpression through a software-assisted method. Gene expression was analyzed by RT-qPCR employing the ΔΔCT method. Kruskal–Wallis and Spearman’s correlation tests were performed. Results: Our mean age was 62.4 (±16.9) years. A total of 37 cases were tumors in the lateral border of the tongue. Age was significantly associated with the anatomical site. 42% (40 of 95) cases were pan-trk positive. A total of 21 cases showed intense immunoexpression predominantly in poorly differentiated OSCC, with a significant correlation between immunoexpression and age and gender. Gene expression showed that poorly differentiated cases exhibited higher NTRK2 expression, while well-differentiated cases demonstrated NTRK3 significantly higher expression. Conclusions: Our results suggest that NTRK family expression is present in OSCC, with differential expression related to differentiation degree. Additional information about their activation or mutational status could reinforce their potential as a possible primary or adjuvant treatment target.

La Odontología, como otras ciencias de la salud, ha registrado una transformación profunda en los últimos años, marcado en última instancia por la introducción de la Inteligencia Artificial (IA), la cual ha emergido como una herramienta transformadora con capacidad de procesar grandes volúmenes de datos y aprender de ellos, lo que ha generado avances significativos en la enseñanza educativa, como por ejemplo en la interpretación de imágenes dentales, la predicción de enfermedades y la optimización de tratamientos. No obstante, el uso de IA en la odontología no está exento de desafíos y consideraciones éticas que deben ser cuidadosamente evaluadas1.

Magnetoluminescent nanomaterials (MLNPs) integrate magnetic and luminescent components for imaging, delivery, and externally controlled interventions. For bone regeneration, their proposed value lies in combining monitoring with magnetic guidance or stimulation during repair. This critical review evaluates how silica and mesoporous silica shells, polymers, core–shell and Janus architectures, and surface ligands affect emission, magnetic response, colloidal stability, loading, and biological interactions. Bone-relevant evidence remains limited and heterogeneous: reported outcomes range from cell tracking and labeling compatibility to material bioactivity, cellular osteogenesis-related responses, and peri-implant bone formation. These endpoints are evaluated separately, and interface-related effects are interpreted in relation to composition, architecture, and testing conditions. Designs developed for cancer imaging and therapy provide complementary evidence requiring dedicated regenerative validation. Recommended priorities are to define the intended monitoring or repair benefit, verify function in the final scaffold or delivery format, establish added value with matched controls, and follow osteogenic, vascular, and immune responses alongside component fate throughout healing. Translation also requires clinically feasible exposure, sterilization compatibility, and reproducible manufacture. Biological magnetic–photonic synergy requires appropriate stimulation controls and interaction analysis, while adaptive control remains a prospective research objective.

Dental adhesion has evolved substantially, transforming restorative dentistry by enabling minimally invasive procedures, highly aesthetic restorations, and significant preservation of tooth structure. However, relevant challenges remain in clinical practice: terminological confusion and a gap between scientific evidence and its everyday application. The classic model of “generations,” from the first to the eighth, was based on the number of operating steps and the chemical evolution of monomers. However, today it could be considered unhelpful, as it does not accurately reflect the mode of action of modern adhesives1,2.