In the quest for chronically reliable and bio-tolerable brain interfaces there has been a steady evolution towards the use of highly flexible, polymer-based electrode arrays. The reduced mechanical mismatch between implant and brain tissue has shown to reduce the evoked immune response, which in turn has a positive effect on signal stability and noise. Unfortunately, the low stiffness of the implants also has practical repercussions, making surgical insertion extremely difficult. In this work we explore the use of dextran as a coating material that temporarily stiffens the implant, preventing buckling during insertion. The mechanical properties of dextran coated neural probes are characterized, as well as the different parameters which influence the dissolution rate. Tuning parameters, such as coating thickness and molecular weight of the used dextran, allows customization of the stiffness and dissolution time to precisely match the user’s needs. Finally, the immunological response to the coated electrodes was analyzed by performing a histological examination after four months of in vivo testing. The results indicated that a very limited amount of glial scar tissue was formed. Neurons have also infiltrated the area that was initially occupied by the dissolving dextran coating. There was no noticeable drop in neuron density around the site of implantation, confirming the suitability of the coating as a temporary aid during implantation of highly flexible polymer-based neural probes.

In this paper, a miniaturized microwave resonator is designed and fabricated. A loop mode resonance is created when the permittivity difference of the two materials loaded in the two fluidic channels are sufficiently large. A highly concentrated electrical field is generated in a microfluidic channel loaded with deionized water to achieve high sensing spatial resolution within a sensing volume of 45 pL. On-wafer measurements are performed by keeping one channel unloaded as a reference while loading the other channel with different mixtures of isopropanol and deionized water. The acquired microwave-microfluidic measurements confirm that the proposed resonator can resolve changes in the permittivity of the loaded liquid between the values of 3.2 and 42.4, making it promising for applications such as mixing monitoring and flow cytometry.

A simplified dielectric material characterization technique that combines an equivalent impedance algorithm and a general “line–line” trace method is introduced. The technique is applicable to every type of transmission lines. Due to the convenient fabrication and the allowance of integration with various polymers, coplanar waveguide transmission lines integrated with an SU-8 microfluidic channel is primarily used in this study. The conformal mapping method, an efficient and straightforward way, is introduced to build the foundation of dielectric material characterization and to optimize the sensor design. A validation measurement of the proposed technique is performed on deionized water, and show valuable consistency with previous reliable data presented in the literature. Next, the technique is applied on solid SU-8 characterization with four groups of on-wafer measurements. SU-8 measurement results and the related uncertainty analysis are demonstrated subsequently.

A multiline and multimaterial calibration method is proposed, which is aimed at replacing state-of-the-art two-tier microwave calibration techniques in liquid characterization process. The technique combines a general ``line-line'' trace method and an equivalent impedance algorithm, which enables to use unknown materials loaded on various lengths of transmission lines in the calibration standards. The validation measurements are performed on coplanar waveguide structures due to the convenient fabrication and easy integration with polymers. Measurement comparison with the previous calibration approach verifies its capability in high-frequency applications.

Objective . This study describes the design and microfabrication of a foldable thin-film neural implant and investigates its suitability for electrical recording of deep-lying brain cavity walls. Approach . A new type of foldable neural electrode array is presented, which can be inserted through a cannula. The microfabricated electrode is specifically designed for electrical recording of the cavity wall of thalamic lesions resulting from stroke. The proof-of-concept is demonstrated by measurements in rat brain cavities. On implantation, the electrode array unfolds in the brain cavity, contacting the cavity walls and allowing recording at multiple anatomical locations. A three-layer microfabrication process based on UV-lithography and Reactive Ion Etching is described. Electrochemical characterization of the electrode is performed in addition to an in vivo experiment in which the implantation procedure and the unfolding of the electrode are tested and visualized. Main results . Electrochemical characterization validated the suitability of the electrode for in vivo use. CT imaging confirmed the unfolding of the electrode in the brain cavity and analysis of recorded local field potentials showed the ability to record neural signals of biological origin. Significance . The conducted research confirms that it is possible to record neural activity from the inside wall of brain cavities at various anatomical locations after a single implantation procedure. This opens up possibilities towards research of abnormal brain cavities and the clinical conditions associated with them, such as central post-stroke pain.