Background/Objectives: The aim of this study was to compare the outcomes of pulpotomy done in primary molars under different treatment settings, namely: Basic Behavior Guidance (BBG), Oral Sedation (OS) and General Anesthesia (GA). Methods: In this is retrospective study, dental records of 79 pediatric dental patients treated in university dental hospital between March 2019 to January 2022 were reviewed. Data collected include: (1) age at the time of receiving the treatment, (2) age at the recall visit, (3) gender, and (4) type of clinical setting when providing the dental treatment (BBG, OS, or GA). A total of 154 primary molars received pulpotomy procedure. Recall visits include clinical and radiographic examination. Results: Clinically, six teeth in the BBG group exfoliated. SSC was lost in all groups, but no significant difference was found (P= 0.236). For the percussion and palpation responses, no significant differences were found between the three groups (p= 0.245 and 0.395 respectively). Radiographic findings showed no significant difference between the three groups when roots and pulp canals and bone resorption were examined (p= 0.313 and 0.193 respectively). Signiant differences were found when dentinal bridge formation was assessed (p=0.003). When the quality of the pulpotomy, success of the SSC, and the success of the pulpotomy were compared, no significant differences were found (P>0.05). Conclusions: No significant differences were found between the three groups when the pulpotomy outcomes were assessed. This retrospective study highlights the effect of treatment settings. Future prospective study is recommended.