Considering the issues of energy shortage and global warming in the near future, developing sustainable and CO₂ emission-free energy sources is necessary for industrialization and civilization.

Temperature/pH dual-responsive hydrogels are a class of smart materials capable of undergoing reversible structural or functional changes in response to temperature and pH stimuli. Owing to their remarkable dual-stimuli-responsive characteristics, these hydrogels have demonstrated significant potential in various biomedical applications, including drug delivery, tissue engineering, and diagnostics technologies, making them a prominent research focus. Although considerable progress has been made in recent years, a systematic summary of the preparation methods, structural design strategies and complex biomedical applications of these materials remains conspicuously absent. Consequently, this review aims to comprehensively examine the latest advancements in this field. First, the primary preparation methods of temperature/pH dual-responsive hydrogels, including chemical crosslinking, physical crosslinking, and hybrid crosslinking, are introduced and compared. Subsequently, the main structural design strategies, including microsphere, core–shell and layered structures, and their corresponding fabrication processes are systematically elucidated. Finally, the recent progress of temperature/pH dual-responsive hydrogels in biomedical applications is discussed, including drug delivery, cancer therapy, biosensing and diagnosis, tissue engineering and regenerative medicine, as well as wound healing. Based on the current research progress, this review also outlines the major challenges in the development of temperature/pH dual-responsive hydrogels, and presents perspectives on future research directions.

A gaseous beam monitor utilizing gas electron multiplier (GEM) and pixel sensors is being developed for the Cooling Storage Ring (CSR) External-target Experiment (CEE) at Heavy Ion Research Facility in Lanzhou (HIRFL). The beam monitor is mainly used to track each beam particle, providing an accurate reconstruction of the primary vertex of the collision. Two generations of the pixel sensors (named Topmetal-CEE) were produced, with the second generation's performance improving over the first one. The design and performance of the prototype are described in the paper. Characterization of the prototype with heavy-ion beams and laser beams are presented, showing a spatial resolution better than 50 μm and a time resolution better than 15 ns.

The cooling storage ring external-target experiment is a large-scale nuclear physics experiment, which aims to study the physics of heavy-ion collisions at low temperatures and high baryon densities. A beam monitor (BM) is placed in the beam line to monitor the beam status and to improve the reconstruction resolution of the primary vertices. The radiation dose and particle fluence stemming from the beam interactions with gases and detector materials affect the performance of the sensors and electronics of BM. This paper uses FLUKA Monte Carlo code to simulate the radiation environment of BM detector. Radiation quantities including the total ionizing dose, 1 MeV neutron equivalent fluence, high-energy hadron flux, thermal neutron flux, and nuclear fragment flux are presented. Results of alternative simulation setups, including adding shielding layers inside the BM, are also investigated.