Inflammation plays a critical role in atherosclerosis. This study examines the effects of ticagrelor and clopidogrel on inflammatory parameters, obtained from complete blood count (CBC) and biochem...

Aim The Naples prognostic score (NPS) simultaneously evaluates inflammation and malnutrition, which are two main factors that play a role in the pathophysiology and prognosis of heart failure (HF). In this study, we aimed to examine the relationship of NPS with in-hospital mortality of hospitalized patients with a diagnosis of HF. Material and Methods   A total of 496 hospitalized HF patients included in this study. The patients were divided into two groups as deceased and living. The clinical and demographic characteristics of each patient were recorded. NPS of each patient was calculated. Results   NPS was significantly higher in the deceased group compared to the living group (3.6±0.61, 3.21±0.97, respectively; p=0.003). According to multivariate regression analysis: NPS (OR: 1.546, 95 % CI: 1.027–2.327; p=0.037), systolic blood pressure (OR: 0.976, 95 % CI: 0.957–0.995; p=0.015), and white blood cell count (OR: 1.072, 95 % CI: 1.007–1142; p=0.03) are independent predictors for in-hospital mortality in HF patients. Conclusion This study demonstrated a strong correlation between NPS and mortality in HF. This new score can be used to predict the prognosis of HF as it shows both the level of inflammation and nutrition.

Older adults face a high risk of in-hospital mortality following acute coronary syndrome (ACS). The C-reactive protein-albumin-lymphocyte (CALLY) index reflects systemic inflammation, immunity, and nutritional status. We investigated its predictive value for in-hospital mortality in elderly ACS patients. A total of 699 older patients diagnosed with ACS were retrospectively analyzed. The cohort was divided into survivors (n = 562) and non-survivors (n = 137). Admission values of serum C-reactive protein, albumin, and lymphocyte counts were utilized to compute the CALLY index. The non-survivor cohort exhibited a remarkably lower CALLY index compared with those who survived (0.22 [0.08-0.78] vs 3.09 [0.73-10.3], P < .001). A CALLY index threshold of ≤0.716 identified in-hospital mortality with 75.4% sensitivity and 74.5% specificity (Area under the curve [AUC] = 0.816, 95% CI: 0.776-0.856, P < .001), showing higher sensitivity and specificity than the Global Registry of Acute Coronary Events (GRACE) score. Multivariable regression revealed that CALLY index <0.716 (odds ratio [OR] = 4.41, 95% CI: 2.27-8.54, P < .001) independently predicted adverse outcomes. The CALLY index may serve as a valuable and independent prognostic marker in elderly patients with ACS.

Background Acute coronary syndrome (ACS) is the most common subtype of coronary artery disease (CAD). It is one of the main reasons affecting the expected life expectancy and quality of life. Objetives In this study, we aimed to investigate the relationship between major adverse cardiac events (MACE) and Hemoglobin (Hb)/Red cell distribution width (RDW) in long-term follow-up after ACS. Methods A total of 1,146 ACS patients were included in the study, being classified according to the type of myocordial [...] Abstract Background Acute coronary syndrome (ACS) is the most common subtype of coronary artery disease (CAD). It is one of the main reasons affecting the expected life expectancy and quality of life. Objetives In this study, we aimed to investigate the relationship between major adverse cardiac events (MACE) and Hemoglobin (Hb)/Red cell distribution width (RDW) in long-term follow-up after ACS. Methods A total of 1,146 ACS patients were included in the study, being classified according to the type of myocordial

Aim: Nondiabetic patients have been studied to determine whether modest elevations in plasma mannose levels may be associated with a greater incidence of coronary artery disease (CAD). Materials & methods: The plasma mannose, lipids (triglyceride, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein) and lactate dehydrogenase levels were successfully evaluated with respect to subsequent CAD using records of 120 nondiabetic patients and 120 healthy volunteers. CAD was identified from myocardial infarction and new diagnoses of angina. Results: Of 120 patients studied, the plasma mannose, triglyceride, lactate dehydrogenase and very low-density lipoprotein levels of patients were significantly higher than control groups. Conclusion: Our findings showed that elevated baseline mannose in plasma was associated with a progressive risk of CAD with time.

Background: The Synergy between Percutaneous Coronary Intervention with Taxus (SYNTAX) Score quantifies the complexity of coronary artery disease. The Controlling Nutritional Status (CONUT) score is a nutritional index linked to cardiovascular outcomes. This study investigates the correlation between SYNTAX Score and CONUT scores in stable angina pectoris (SAP). Methods: This single-center, retrospective study included 259 patients with a first-time diagnosis of SAP who underwent coronary angiography. Patients were divided into low SYNTAX Score (≤22, n = 192) and high SYNTAX Score (>22, n = 67) groups. The CONUT score, derived from serum albumin, total lymphocyte count, and total cholesterol, was calculated for all patients. Results: The median CONUT score was significantly higher in the high SYNTAX Score group (3 vs. 1; P < 0.001). Impaired nutritional status (CONUT ≥ 2) was more prevalent in the high SYNTAX Score group (71.6 vs. 37.5%; P < 0.001). A significant positive correlation was found between SYNTAX Score and CONUT score ( P < 0.001). A CONUT score more than 1.5 predicted high SYNTAX Score with 71.6% sensitivity and 62.5% specificity [area under the curve = 0.746, 95% confidence interval (CI): 0.672–0.820, P < 0.001]. In multivariable analysis, diabetes mellitus [odds ratio (OR): 2.47, 95% CI: 1.27–4.83, P = 0.008] and CONUT score (OR: 1.60, 95% CI: 1.32–1.95, P < 0.001) were independent predictors of high SS. Conclusion: A significant positive correlation exists between SYNTAX Score and CONUT score in SAP patients, indicating that worse nutritional status is associated with more complex disease. Nutritional assessment should be integrated into risk evaluation.