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Preventive and corrective maintenance of the different components of rolling stock is mandatory to guarantee the safety of passengers and workers when using rail transport. Although different studies and models of degradation have been developed, the actual effect of rolling stock component defects in the infrastructure is not totally clear. From the different components of rolling stock, failures of elements of the running gear are more likely to cause track deterioration due to more severe wear wheel-rail interactions, producing undesirable effects on the infrastructure that can end in derailments. The aim of this paper is both to analyse through a failure modes and criticality analysis (FMECA) the different failure modes of the running gear and their effect on rail infrastructure and to analyse the prioritisation based on their criticality in order to give some insights into which components should receive special attention in maintenance procedures. Failures based on maintenance registers of passenger vehicles of railway companies involved in the Assets4Rail project were analysed. Results showed that defects related to wheels such as cracks, the movement of the wheel in the axle seat, failure of the axlebox bearing, or damage of the bogie frame are some of the failures with more severe consequences.
Sara Poveda-Reyes; Luca Rizzetto; Chiara Triti; Dachuan Shi; Elena García-Jiménez; Gemma D. Molero; Francisco E. Santarremigia. Risk evaluation of failures of the running gear with effects on rail infrastructure. Engineering Failure Analysis 2021, 128, 105613 .
AMA StyleSara Poveda-Reyes, Luca Rizzetto, Chiara Triti, Dachuan Shi, Elena García-Jiménez, Gemma D. Molero, Francisco E. Santarremigia. Risk evaluation of failures of the running gear with effects on rail infrastructure. Engineering Failure Analysis. 2021; 128 ():105613.
Chicago/Turabian StyleSara Poveda-Reyes; Luca Rizzetto; Chiara Triti; Dachuan Shi; Elena García-Jiménez; Gemma D. Molero; Francisco E. Santarremigia. 2021. "Risk evaluation of failures of the running gear with effects on rail infrastructure." Engineering Failure Analysis 128, no. : 105613.
It is well established that the transport sector is not an equalitarian sector. To develop a sustainable society, a more equalitarian and safe transport system for both users and transport sector employees is needed. This work prioritizes the needs and barriers previously identified as relevant among transport system users and employees for four different transport scenarios (railways, autonomous vehicles (AVs), bicycle-sharing services (BSSs), and employment). The aim of this paper is to prioritize the factors affecting women in these four transport scenarios with the help of a survey followed by the application of mathematical and computational algorithms based on the analytic hierarchy process (AHP) methodology. The identification of factors with higher influence in the fair participation of women in the transport sector will help transport planners, bike-sharing system owners, decision-makers, transport companies, and regulatory professionals to develop measures that could plausibly increase the proportion of women as users of BSSs, users of rail public transport, and AVs, as well as employees in the transport sector for a sustainable society. The results indicated that safety and security were the most challenging factors for railways. Weather, topography, and family responsibilities were shown to have a high influence on the use of BSSs. In the case of autonomous vehicles, the simultaneity and trust in the technology are the main opportunities to influence the acceptance of such vehicles. Finally, for transport employment, caring and parenting responsibilities were the factors that had the largest effect. Some differences in priorities were found for different profiles of women.
Sara Poveda-Reyes; Ashwani Malviya; Elena García-Jiménez; Gemma Molero; Maria Leva; Francisco Santarremigia. Application of Mathematical and Computational Methods to Identify Women’s Priorities in Transport. Sustainability 2021, 13, 2845 .
AMA StyleSara Poveda-Reyes, Ashwani Malviya, Elena García-Jiménez, Gemma Molero, Maria Leva, Francisco Santarremigia. Application of Mathematical and Computational Methods to Identify Women’s Priorities in Transport. Sustainability. 2021; 13 (5):2845.
Chicago/Turabian StyleSara Poveda-Reyes; Ashwani Malviya; Elena García-Jiménez; Gemma Molero; Maria Leva; Francisco Santarremigia. 2021. "Application of Mathematical and Computational Methods to Identify Women’s Priorities in Transport." Sustainability 13, no. 5: 2845.
This study focuses on the quantification of the influence of rolling stock failures (RSFs) on railway infrastructure. Taking the wheel flat, a common RSF, as an example, we introduce four quantification indexes to evaluate the influence on the following four deterioration mechanisms: track settlement (TS), track component fatigue (TCF), abrasive wear (AW), and rolling contact fatigue (RCF). Our results indicate that TS, TCF, and AW increase sharply with the increase of the wheel flat length and the vehicle speed, and this increasing trend becomes more acute with the increase of the wheel flat length and the vehicle speed. At low speeds, RCF increases gradually as the wheel flat length increases; at high speeds, it increases sharply at first and then decreases gradually. The influence of the wheel flat on TCF and AW is the most obvious, followed by TS and RCF. These findings can help infrastructure managers (IMs) to better understand infrastructure conditions related to RSFs and can aid them in managing problems with vehicle abnormality in track access charging.
Yun-Guang Ye; Da-Chuan Shi; Sara Poveda-Reyes; Markus Hecht. Quantification of the influence of rolling stock failures on track deterioration. Journal of Zhejiang University-SCIENCE A 2020, 21, 783 -798.
AMA StyleYun-Guang Ye, Da-Chuan Shi, Sara Poveda-Reyes, Markus Hecht. Quantification of the influence of rolling stock failures on track deterioration. Journal of Zhejiang University-SCIENCE A. 2020; 21 (10):783-798.
Chicago/Turabian StyleYun-Guang Ye; Da-Chuan Shi; Sara Poveda-Reyes; Markus Hecht. 2020. "Quantification of the influence of rolling stock failures on track deterioration." Journal of Zhejiang University-SCIENCE A 21, no. 10: 783-798.
This work analyzes gendered processes by a methodology based on clustering factors with influence in the decision-making process of women as users or employees of the transport system. Considering gender as a social construction which changes over time and space, this study is based on the concept of a woman as a person who adopts this role in society. This paper performs a deep analysis of those factors women consider as needs and barriers to use or work in the transport system in four scenarios: railway public transport infrastructures, automated vehicles, bicycle sharing, and jobholders. A literature review and focus group discussions were performed under the consideration that the definition of woman includes the addition of several personal characteristics (age, sexual orientation, family responsibilities, and culture). The data analysis allowed the identification of fairness characteristics (FCs) that affect the interaction of women with the transport system for each scenario. A methodology for clustering the fairness characteristics identified the main areas of action to improve the inclusion of women within each use case. Further studies will be focused on the quantification and prioritization of the FCs through mathematical methods and the suggestion of inclusive measures by an interdisciplinary panel.
Elena García-Jiménez; Sara Poveda-Reyes; Gemma Dolores Molero; Francisco Enrique Santarremigia; Andrea Gorrini; Yvonne Hail; Augustus Ababio-Donkor; Maria Chiara Leva; Filomena Mauriello. Methodology for Gender Analysis in Transport: Factors with Influence in Women’s Inclusion as Professionals and Users of Transport Infrastructures. Sustainability 2020, 12, 3656 .
AMA StyleElena García-Jiménez, Sara Poveda-Reyes, Gemma Dolores Molero, Francisco Enrique Santarremigia, Andrea Gorrini, Yvonne Hail, Augustus Ababio-Donkor, Maria Chiara Leva, Filomena Mauriello. Methodology for Gender Analysis in Transport: Factors with Influence in Women’s Inclusion as Professionals and Users of Transport Infrastructures. Sustainability. 2020; 12 (9):3656.
Chicago/Turabian StyleElena García-Jiménez; Sara Poveda-Reyes; Gemma Dolores Molero; Francisco Enrique Santarremigia; Andrea Gorrini; Yvonne Hail; Augustus Ababio-Donkor; Maria Chiara Leva; Filomena Mauriello. 2020. "Methodology for Gender Analysis in Transport: Factors with Influence in Women’s Inclusion as Professionals and Users of Transport Infrastructures." Sustainability 12, no. 9: 3656.
Containers entering and leaving ports are stored temporarily in the container storage yard. It is very common that ports storage in the same area non-dangerous products and dangerous goods with the risk that entails. This situation highlights the need to develop special inland terminals for containers with dangerous goods (ITDG) or at least a separated zone within the port for the storage of the dangerous goods (port inland terminal for dangerous goods [PITDG]), where containers with hazards can be stored without restrictions. The main objective of this paper is to contribute to the process of designing the layout of safe, green, and cost-efficient ITDG and PITDG by means of a methodology that would help terminal managers and designers to make decisions in a systematic way. An expert panel formed by 10 experts evaluated the layouts linked to straddle carriers, forklifts, reach stackers, platforms, and gantry cranes and achieved consensus following the Delphi method. The prioritisation of alternatives from different criteria or perspectives (e.g. economic, environment, safety, etc.) was analysed using the analytic hierarchy process (AHP). This method allows for consideration of safety, environmental, and operational criteria simultaneously in the decision-making process, which are otherwise difficult to consider. According to the criteria analysed, it was found that the layout related to platforms is the most suitable from a global point of view, followed by the layout related to gantry cranes. To ensure the robustness of the results, a sensitivity analysis was performed.
Miguel Hervás-Peralta; Sara Poveda-Reyes; Francisco Enrique Santarremigia; Gemma Dolores Molero. Designing the layout of terminals with dangerous goods for safer and more secure ports and hinterlands. Case Studies on Transport Policy 2020, 8, 300 -310.
AMA StyleMiguel Hervás-Peralta, Sara Poveda-Reyes, Francisco Enrique Santarremigia, Gemma Dolores Molero. Designing the layout of terminals with dangerous goods for safer and more secure ports and hinterlands. Case Studies on Transport Policy. 2020; 8 (2):300-310.
Chicago/Turabian StyleMiguel Hervás-Peralta; Sara Poveda-Reyes; Francisco Enrique Santarremigia; Gemma Dolores Molero. 2020. "Designing the layout of terminals with dangerous goods for safer and more secure ports and hinterlands." Case Studies on Transport Policy 8, no. 2: 300-310.
The increased number of transports with dangerous goods (TDG) increases the risk of both accidents and terrorist attacks. Digitalisation is crucial in order to avoid human errors and to increase safety, security and efficiency, however there are few research studies that analyse digitalisation for the TDG, this being the first time, to the author’s knowledge, that barriers to the implementation of information and communication technology (ICT) solutions for the transport of dangerous goods has been analysed. A new elicitation methodology called the ‘implementation acceleration methodology for ICT (IAM-ICT)’ has been created, with the aim of identifying and hierarchizing potential barriers to the implementation and integration of ICT solutions involved in the multimodal TDG, and with a view to overcoming the most relevant problems at an early stage. This methodology combines user-driven innovation (UDI), the analytic hierarchy process (AHP) and Bayesian networks. The application of this methodology, which is easily replicable in other fields, will enable a better design of ICT solutions so that they can be implemented and integrated in SMEs and large companies. The results show a hierarchy of potential barriers for a multi-modular ICT solution used as use case study, in two different co-designed schemes for a small and medium enterprise (SME) and for a large company.
Gemma Dolores Molero; Francisco Enrique Santarremigia; Sara Poveda-Reyes; Melanie Mayrhofer; Samir Awad-Núñez; Abdullah Kassabji. Key factors for the implementation and integration of innovative ICT solutions in SMEs and large companies involved in the multimodal transport of dangerous goods. European Transport Research Review 2019, 11, 28 .
AMA StyleGemma Dolores Molero, Francisco Enrique Santarremigia, Sara Poveda-Reyes, Melanie Mayrhofer, Samir Awad-Núñez, Abdullah Kassabji. Key factors for the implementation and integration of innovative ICT solutions in SMEs and large companies involved in the multimodal transport of dangerous goods. European Transport Research Review. 2019; 11 (1):28.
Chicago/Turabian StyleGemma Dolores Molero; Francisco Enrique Santarremigia; Sara Poveda-Reyes; Melanie Mayrhofer; Samir Awad-Núñez; Abdullah Kassabji. 2019. "Key factors for the implementation and integration of innovative ICT solutions in SMEs and large companies involved in the multimodal transport of dangerous goods." European Transport Research Review 11, no. 1: 28.
Maritime transport in the European Union has increased in the last years, triggering congestion in many of the most important sea and river ports. A lot of works have highlighted how the connection between these ports and dry ports can contribute to reducing port congestion and emission of greenhouse gases (GHGs). This work aims to improve the knowledge about the functionalities of Terminal Operating Systems (TOSs) managing container terminals of sea, river, and dry ports, with the aim of improving their performance and contributing to reducing congestion and GHG emissions to achieve a higher sustainability. The contribution and novelty of this paper in the field of container-terminals logistics research is the use of the Analytic Hierarchy Process (AHP) to identify and hierarchize TOS functionalities. The robustness of the model was checked by applying a sensitivity analysis. One hundred and seven functionalities were grouped into six main clusters: Warehouse, Maritime Operations, Gate, Master Data, Communications, and ERP (Enterprise Resource Planning) Dashboard. The results show that time tracking of vessels, space optimization, development of loading and unloading lists, and optimization of container locations are the most important functionalities of a TOS. This work is addressed to developers, sellers, managers, and users of TOSs and researchers working on container-terminal performance.
Miguel Hervás-Peralta; Sara Poveda-Reyes; Gemma Dolores Molero; Francisco Enrique Santarremigia; Juan-Pascual Pastor-Ferrando. Improving the Performance of Dry and Maritime Ports by Increasing Knowledge about the Most Relevant Functionalities of the Terminal Operating System (TOS). Sustainability 2019, 11, 1648 .
AMA StyleMiguel Hervás-Peralta, Sara Poveda-Reyes, Gemma Dolores Molero, Francisco Enrique Santarremigia, Juan-Pascual Pastor-Ferrando. Improving the Performance of Dry and Maritime Ports by Increasing Knowledge about the Most Relevant Functionalities of the Terminal Operating System (TOS). Sustainability. 2019; 11 (6):1648.
Chicago/Turabian StyleMiguel Hervás-Peralta; Sara Poveda-Reyes; Gemma Dolores Molero; Francisco Enrique Santarremigia; Juan-Pascual Pastor-Ferrando. 2019. "Improving the Performance of Dry and Maritime Ports by Increasing Knowledge about the Most Relevant Functionalities of the Terminal Operating System (TOS)." Sustainability 11, no. 6: 1648.
While rail transport is growing for medium-distance journeys, the first and last miles are travelled by road, marking a change of transport mode in inland terminals (ITs). Moreover, the introduction of ITs in seaport hinterlands is increasing with a view to decongesting ports, and the best transport mode to connect these ITs with ports is that of rail. In 2013, chemicals were involved in 48 rail accidents in the EU-28 and in 667 in the United States (US). An appropriate design for the layout of inland terminals for containers with dangerous goods (ITDGs) involved in the rail system will increase the safety and operability of rail transport, avoiding accidents such as Tianjin (2015). The novelty of this work is a methodology to design the layout of ITDGs involved in rail transport through a hierarchy of container handling equipment (CHE), used in the yard of the terminal for a safer, more resilient and more environmentally friendly rail transport. The AHP (analytic hierarchy process) was used to hierarchize five alternative layouts, one for each CHE used in the yard; and according to criteria belonging to three areas: safety and security, environment and equipment performance. Results show that a layout linked to platforms is the preferred alternative for storing containers with dangerous goods (DGs) in ITs connected to railways. The implementation of this methodology will reduce consequences in the case of a serious accident in, or terrorist attack on, ITDGs involved in the rail system and GHG (greenhouse gas) emissions in the terminal.
Francisco Enrique Santarremigia; Gemma Dolores Molero; Sara Poveda-Reyes; José Aguilar. Railway safety by designing the layout of inland terminals with dangerous goods connected with the rail transport system. Safety Science 2018, 110, 206 -216.
AMA StyleFrancisco Enrique Santarremigia, Gemma Dolores Molero, Sara Poveda-Reyes, José Aguilar. Railway safety by designing the layout of inland terminals with dangerous goods connected with the rail transport system. Safety Science. 2018; 110 ():206-216.
Chicago/Turabian StyleFrancisco Enrique Santarremigia; Gemma Dolores Molero; Sara Poveda-Reyes; José Aguilar. 2018. "Railway safety by designing the layout of inland terminals with dangerous goods connected with the rail transport system." Safety Science 110, no. : 206-216.
Gelatin–hyaluronic acid (Gel–HA) hybrid hydrogels have been proposed as matrices for tissue engineering because of their ability to mimic the architecture of the extracellular matrix. Our aim was to explore whether tyramine conjugates of Gel and HA, producing injectable hydrogels, are able to induce a particular phenotype of encapsulated human mesenchymal stem cells without the need for growth factors. While pure Gel allowed good cell adhesion without remarkable differentiation and pure HA triggered chondrogenic differentiation without cell spreading, the hybrids, especially those rich in HA, promoted chondrogenic differentiation as well as cell proliferation and adhesion. Secretion of chondrogenic markers such as aggrecan, SOX-9, collagen type II, and glycosaminoglycans was observed, whereas osteogenic, myogenic, and adipogenic markers (RUNX2, sarcomeric myosin, and lipoproteinlipase, respectively) were not present after 2 weeks in the growth medium. The most promising matrix for chondrogenesis seems to be a mixture containing 70% HA and 30% Gel as it is the material with the best mechanical properties from all compositions tested here, and at the same time, it provides an environment suitable for balanced cell adhesion and chondrogenic differentiation. Thus, it represents a system that has a high potential to be used as the injectable material for cartilage regeneration therapies.
Vladimira Moulisova; Sara Poveda-Reyes; Esther Sanmartín-Masiá; Luis Quintanilla-Sierra; Manuel Salmerón-Sánchez; Gloria Gallego Ferrer. Hybrid Protein–Glycosaminoglycan Hydrogels Promote Chondrogenic Stem Cell Differentiation. ACS Omega 2017, 2, 7609 -7620.
AMA StyleVladimira Moulisova, Sara Poveda-Reyes, Esther Sanmartín-Masiá, Luis Quintanilla-Sierra, Manuel Salmerón-Sánchez, Gloria Gallego Ferrer. Hybrid Protein–Glycosaminoglycan Hydrogels Promote Chondrogenic Stem Cell Differentiation. ACS Omega. 2017; 2 (11):7609-7620.
Chicago/Turabian StyleVladimira Moulisova; Sara Poveda-Reyes; Esther Sanmartín-Masiá; Luis Quintanilla-Sierra; Manuel Salmerón-Sánchez; Gloria Gallego Ferrer. 2017. "Hybrid Protein–Glycosaminoglycan Hydrogels Promote Chondrogenic Stem Cell Differentiation." ACS Omega 2, no. 11: 7609-7620.
Esther Sanmartín-Masiá; Sara Poveda Reyes; Gloria Gallego-Ferrer. Extracellular matrix–inspired gelatin/hyaluronic acid injectable hydrogels. International Journal of Polymeric Materials and Polymeric Biomaterials 2016, 66, 280 -288.
AMA StyleEsther Sanmartín-Masiá, Sara Poveda Reyes, Gloria Gallego-Ferrer. Extracellular matrix–inspired gelatin/hyaluronic acid injectable hydrogels. International Journal of Polymeric Materials and Polymeric Biomaterials. 2016; 66 (6):280-288.
Chicago/Turabian StyleEsther Sanmartín-Masiá; Sara Poveda Reyes; Gloria Gallego-Ferrer. 2016. "Extracellular matrix–inspired gelatin/hyaluronic acid injectable hydrogels." International Journal of Polymeric Materials and Polymeric Biomaterials 66, no. 6: 280-288.
Cells interact mechanically with their environment, exerting mechanical forces that probe the extracellular matrix (ECM). The mechanical properties of the ECM determine cell behavior and control cell differentiation both in 2D and 3D environments. Gelatin (Gel) is a soft hydrogel into which cells can be embedded. This study shows significant 3D Gel shrinking due to the high traction cellular forces exerted by the cells on the matrix, which prevents cell differentiation. To modulate this process, Gel with hyaluronic acid (HA) has been combined in an injectable crosslinked hydrogel with controlled Gel-HA ratio. HA increases matrix stiffness. The addition of small amounts of HA leads to a significant reduction in hydrogel shrinking after cell encapsulation (C2C12 myoblasts). We show that hydrogel stiffness counterbalanced traction forces of cells and this was decisive in promoting cell differentiation and myotube formation of C2C12 encapsulated in the hybrid hydrogels.
Sara Poveda Reyes; Vladimira Moulisova; Esther Sanmartín-Masiá; Luis Quintanilla-Sierra; Manuel Salmerón-Sánchez; Gloria Gallego-Ferrer. Gelatin-Hyaluronic Acid Hydrogels with Tuned Stiffness to Counterbalance Cellular Forces and Promote Cell Differentiation. Macromolecular Bioscience 2016, 16, 1311 -1324.
AMA StyleSara Poveda Reyes, Vladimira Moulisova, Esther Sanmartín-Masiá, Luis Quintanilla-Sierra, Manuel Salmerón-Sánchez, Gloria Gallego-Ferrer. Gelatin-Hyaluronic Acid Hydrogels with Tuned Stiffness to Counterbalance Cellular Forces and Promote Cell Differentiation. Macromolecular Bioscience. 2016; 16 (9):1311-1324.
Chicago/Turabian StyleSara Poveda Reyes; Vladimira Moulisova; Esther Sanmartín-Masiá; Luis Quintanilla-Sierra; Manuel Salmerón-Sánchez; Gloria Gallego-Ferrer. 2016. "Gelatin-Hyaluronic Acid Hydrogels with Tuned Stiffness to Counterbalance Cellular Forces and Promote Cell Differentiation." Macromolecular Bioscience 16, no. 9: 1311-1324.
Sara Poveda Reyes. Protein-based injectable hydrogels towards the regeneration of articular cartilage. Protein-based injectable hydrogels towards the regeneration of articular cartilage 2016, 1 .
AMA StyleSara Poveda Reyes. Protein-based injectable hydrogels towards the regeneration of articular cartilage. Protein-based injectable hydrogels towards the regeneration of articular cartilage. 2016; ():1.
Chicago/Turabian StyleSara Poveda Reyes. 2016. "Protein-based injectable hydrogels towards the regeneration of articular cartilage." Protein-based injectable hydrogels towards the regeneration of articular cartilage , no. : 1.
Sara Poveda Reyes; Aleixandre Rodrigo-Navarro; Tatiana C. Gamboa-Martínez; José C. Rodíguez-Cabello; Luis Quintanilla-Sierra; Ulrica Edlund; Gloria Gallego Ferrer. Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering. Polymer 2015, 74, 224 -234.
AMA StyleSara Poveda Reyes, Aleixandre Rodrigo-Navarro, Tatiana C. Gamboa-Martínez, José C. Rodíguez-Cabello, Luis Quintanilla-Sierra, Ulrica Edlund, Gloria Gallego Ferrer. Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering. Polymer. 2015; 74 ():224-234.
Chicago/Turabian StyleSara Poveda Reyes; Aleixandre Rodrigo-Navarro; Tatiana C. Gamboa-Martínez; José C. Rodíguez-Cabello; Luis Quintanilla-Sierra; Ulrica Edlund; Gloria Gallego Ferrer. 2015. "Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering." Polymer 74, no. : 224-234.
Short poly‐l‐lactic acid (PLLA) microfibers have been produced in order to disperse them into the gelatin solution and enable injection in the tissue defect prior to gel formation. Two methods for fabrication of loose fibers with submicrometric dimensions are presented in this paper. One is based on manufacturing electrospun meshes and subsequent milling (PLLA‐ES) and the other involves projection of a PLLA solution into a high turbulent non‐solvent medium (PLLA‐HT). Composites produced with PLLA‐ES show a compression Young's modulus from 2.65 kPa for the pure gelatin to 6.69 kPa for the composite with 1.5% PLLA‐ES fibers. The new injectable gelatin–fiber composites are not cytotoxic.
Sara Poveda Reyes; Leonardo Rubén Mellera-Oglialoro; Rebeca Martinez-Haya; Tatiana Carolina Gamboa-Martínez; Jose Luis Gomez Ribelles; Gloria Gallego-Ferrer. Reinforcing an Injectable Gelatin Hydrogel with PLLA Microfibers: Two Routes for Short Fiber Production. Macromolecular Materials and Engineering 2015, 300, 977 -988.
AMA StyleSara Poveda Reyes, Leonardo Rubén Mellera-Oglialoro, Rebeca Martinez-Haya, Tatiana Carolina Gamboa-Martínez, Jose Luis Gomez Ribelles, Gloria Gallego-Ferrer. Reinforcing an Injectable Gelatin Hydrogel with PLLA Microfibers: Two Routes for Short Fiber Production. Macromolecular Materials and Engineering. 2015; 300 (10):977-988.
Chicago/Turabian StyleSara Poveda Reyes; Leonardo Rubén Mellera-Oglialoro; Rebeca Martinez-Haya; Tatiana Carolina Gamboa-Martínez; Jose Luis Gomez Ribelles; Gloria Gallego-Ferrer. 2015. "Reinforcing an Injectable Gelatin Hydrogel with PLLA Microfibers: Two Routes for Short Fiber Production." Macromolecular Materials and Engineering 300, no. 10: 977-988.
A hydrogel based on interpenetrating polymer networks (IPNs) has been designed to act as a platform in an articular cartilage bioreactor for the ex vivo test of scaffolds, simulating the host tissue. Poly(2-hydroxyethyl acrylate) (PHEA) has been mechanically reinforced by its interpenetration with poly(ethyl acrylate). The resulting IPNs are phase separated systems with a porosity that increases with the amount of PHEA. Compression Young's modulus decreases and permeability increases when increasing the PHEA content in the samples, being the IPN with a 79% of PHEA the best candidate to mimic articular cartilage.
Sara Poveda-Reyes; Tatiana C. Gamboa-Martínez; Sara Manzano; Mohamed Hamdy Doweidar; José Luis Gómez Ribelles; Ignacio Ochoa; Gloria Gallego Ferrer. Engineering Interpenetrating Polymer Networks of Poly(2-Hydroxyethyl Acrylate) asEx VivoPlatforms for Articular Cartilage Regeneration. International Journal of Polymeric Materials and Polymeric Biomaterials 2015, 64, 745 -754.
AMA StyleSara Poveda-Reyes, Tatiana C. Gamboa-Martínez, Sara Manzano, Mohamed Hamdy Doweidar, José Luis Gómez Ribelles, Ignacio Ochoa, Gloria Gallego Ferrer. Engineering Interpenetrating Polymer Networks of Poly(2-Hydroxyethyl Acrylate) asEx VivoPlatforms for Articular Cartilage Regeneration. International Journal of Polymeric Materials and Polymeric Biomaterials. 2015; 64 (14):745-754.
Chicago/Turabian StyleSara Poveda-Reyes; Tatiana C. Gamboa-Martínez; Sara Manzano; Mohamed Hamdy Doweidar; José Luis Gómez Ribelles; Ignacio Ochoa; Gloria Gallego Ferrer. 2015. "Engineering Interpenetrating Polymer Networks of Poly(2-Hydroxyethyl Acrylate) asEx VivoPlatforms for Articular Cartilage Regeneration." International Journal of Polymeric Materials and Polymeric Biomaterials 64, no. 14: 745-754.
Interpenetrated polymer networks (IPNs), composed by two independent polymeric networks that spatially interpenetrate, are considered as valuable systems to control permeability and mechanical properties of hydrogels for biomedical applications. Specifically, poly(ethyl acrylate) (PEA)-poly(2-hydroxyethyl acrylate) (PHEA) IPNs have been explored as good hydrogels for mimicking articular cartilage. These lattices are proposed as matrix implants in cartilage damaged areas to avoid the discontinuity in flow uptake preventing its deterioration. The permeability of these implants is a key parameter that influences their success, by affecting oxygen and nutrient transport and removing cellular waste products to healthy cartilage. Experimental try-and-error approaches are mostly used to optimize the composition of such structures. However, computational simulation may offer a more exhaustive tool to test and screen out biomaterials mimicking cartilage, avoiding expensive and time-consuming experimental tests. An accurate and efficient prediction of material's permeability and internal directionality and magnitude of the fluid flow could be highly useful when optimizing biomaterials design processes. Here we present a 3D computational model based on Sussman-Bathe hyperelastic material behaviour. A fluid structure analysis is performed with ADINA software, considering these materials as two phases composites where the solid part is saturated by the fluid. The model is able to simulate the behaviour of three non-biodegradable hydrogel compositions, where percentages of PEA and PHEA are varied. Specifically, the aim of this study is (i) to verify the validity of the Sussman-Bathe material model to simulate the response of the PEA-PHEA biomaterials; (ii) to predict the fluid flux and the permeability of the proposed IPN hydrogels and (iii) to study the material domains where the passage of nutrients and cellular waste products is reduced leading to an inadequate flux distribution in healthy cartilage tissue. The obtained results show how the model predicts the permeability of the PEA-PHEA hydrogels and simulates the internal behaviour of the samples and shows the distribution and quantification of fluid flux.
Sara Manzano; Sara Poveda-Reyes; Gloria Gallego Ferrer; Ignacio Ochoa; Mohamed Hamdy Doweidar. Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing. Computer Methods and Programs in Biomedicine 2014, 116, 249 -259.
AMA StyleSara Manzano, Sara Poveda-Reyes, Gloria Gallego Ferrer, Ignacio Ochoa, Mohamed Hamdy Doweidar. Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing. Computer Methods and Programs in Biomedicine. 2014; 116 (3):249-259.
Chicago/Turabian StyleSara Manzano; Sara Poveda-Reyes; Gloria Gallego Ferrer; Ignacio Ochoa; Mohamed Hamdy Doweidar. 2014. "Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing." Computer Methods and Programs in Biomedicine 116, no. 3: 249-259.
Excessive water sorption and low mechanical properties are a severe drawback in some biomedical applications of hyaluronic acid (HA). A way to improve these properties is here explored through the novel concept of nanohybrid hydrogels consisting of a HA matrix including different amounts of silica-derived species. This inorganic filler phase controls the mechanical and swelling properties of HA cross-linked matrices. Below a 2 wt % of silica in the systems, nanoparticle aggregates of tens of nanometers and silica oligomers are distributed more or less homogeneously throughout the organic matrix, without percolating. This morphology of the silica phase is accompanied by an increased swelling degree of the composite when compared with pure HA. For higher silica mass ratios in the composites the inorganic counterpart coalesces, leading to a continuous inorganic silica network interpenetrated with the organic HA network, which coexists with a dispersed phase of silica–nanoparticle aggregates. Silica oligomers originating in the exposition of the nanoparticles to reactives during the composite preparation procedure contribute to the continuity of the silica network. For these compositions, swelling is reduced three times when compared with pure HA, and a significant improvement of the mechanical properties occurs. Water-containing samples of these materials exhibited a glass transition, which pure dry HA does not. None of the compositions studied showed any cytotoxicity. Thus, the materials could be of use in tissue engineering applications where these properties of HA need to be modulated.
Ana Vallés-Lluch; Sara Poveda Reyes; Pedro Amoros; D. Beltrán; M. Monleón Pradas. Hyaluronic Acid–Silica Nanohybrid Gels. Biomacromolecules 2013, 14, 4217 -4225.
AMA StyleAna Vallés-Lluch, Sara Poveda Reyes, Pedro Amoros, D. Beltrán, M. Monleón Pradas. Hyaluronic Acid–Silica Nanohybrid Gels. Biomacromolecules. 2013; 14 (12):4217-4225.
Chicago/Turabian StyleAna Vallés-Lluch; Sara Poveda Reyes; Pedro Amoros; D. Beltrán; M. Monleón Pradas. 2013. "Hyaluronic Acid–Silica Nanohybrid Gels." Biomacromolecules 14, no. 12: 4217-4225.