Dr. Wenhui Wu
prof
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Academic Career Length
17Years (2010-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
JEJeevithan Elango
Jeevithan ElangoCHChunyu Hou
Chunyu HouBBBin Bao
Bin BaoSWShujun Wang
Shujun WangJVJosé Eduardo Maté-Sánchez de Val
José Eduardo Maté-Sánchez de ValWenhui WuCollagen, an extracellular protein, covers the entire human body and has several important biological functions in normal physiology. Recently, collagen from non-human sources has attracted attention for therapeutic management and biomedical applications. In this regard, both land-based animals such as cow, pig, chicken, camel, and sheep, and marine-based resources such as fish, octopus, starfish, sea-cucumber, and jellyfish are widely used for collagen extraction. The extracted collagen is transformed into collagen peptides, hydrolysates, films, hydrogels, scaffolds, sponges and 3D matrix for food and biomedical applications. In addition, many strategic ideas are continuously emerging to develop innovative advanced collagen biomaterials. For this purpose, it is important to understand the fundamental perception of how collagen communicates with receptors of biological cells to trigger cell signaling pathways. Therefore, this review discloses the molecular interaction of collagen with cell receptor molecules to carry out cellular signaling in biological pathways. By understanding the actual mechanism, this review opens up several new concepts to carry out next level research in collagen biomaterials.
Journal Article
JCJingjing Chen
Jingjing ChenKGKaili Gao
Kaili GaoSLShu Liu
Shu LiuSWShujun Wang
Shujun Wang
Jeevithan ElangoWenhui Wu +3
The development of biomaterials with the potential to accelerate wound healing is a great challenge in biomedicine. In this study, four types of samples including pepsin soluble collagen sponge (PCS), acid soluble collagen sponge (ACS), bovine collagen electrospun I (BCE I) and bovine collagen electrospun II (BCE II) were used as wound dressing materials. We showed that the PCS, ACS, BCE I and BCE II treated rats increased the percentage of wound contraction, reduced the inflammatory infiltration, and accelerated the epithelization and healing. PCS, ACS, BCE I, and BCE II significantly enhanced the total protein and hydroxyproline level in rats. ACS could induce more fibroblasts proliferation and differentiation than PCS, however, both PCS and ACS had a lower effect than BCE I and BCE II. PCS, ACS, BCE I, and BCE II could regulate deposition of collagen, which led to excellent alignment in the wound healing process. There were similar effects on inducing the level of cytokines including EGF, FGF, and vascular endothelial marker CD31 among these four groups. Accordingly, this study disclosed that collagens (PCS and ACS) from tilapia skin and bovine collagen electrospun (BCE I and BCE II) have significant bioactivity and could accelerate wound healing rapidly and effectively in rat model.
Journal Article
Jeevithan ElangoBBBin Bao
Bin BaoYBYongshi Bu
Yongshi BuYZYu Zhou
Yu ZhouQZQingbo Zhao
Qingbo ZhaoWenhui WuType II acid soluble collagen (CIIA), pepsin soluble collagen (CIIP) and type II gelatin (GII) were isolated from silvertip shark (Carcharhinus albimarginatus) cartilage and examined for their physicochemical and antioxidant properties. GII had a higher hydroxyproline content (173 mg/g) than the collagens and cartilage. CIIA, CIIP and GII were composed of two identical α1 and β chains and were characterized as type II. Amino acid analysis of CIIA, CIIP and GII indicated imino acid contents of 150, 156 and 153 amino acid residues per 1000 residues, respectively. Differing Fourier transform infrared (FTIR) spectra of CIIA, CIIP and GII were observed, which suggested that the isolation process affected the secondary structure and molecular order of collagen, particularly the triple-helical structure. The denaturation temperature of GII (32.5 °C) was higher than that of CIIA and CIIP. The antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl radicals and the reducing power of CIIP was greater than that of CIIA and GII. SEM microstructure of the collagens depicted a porous, fibrillary and multi-layered structure. Accordingly, the physicochemical and antioxidant properties of type II collagens (CIIA, CIIP) and GII isolated from shark cartilage were found to be suitable for biomedical applications.
1 October 2016 in International Journal of Biological Macromolecules
Journal Article
Jeevithan ElangoJZJingyi Zhang
Jingyi Zhang
BBBin Bao
Bin Bao
KPKrishnamoorthy Palaniyandi
Krishnamoorthy Palaniyandi
SWShujun Wang
Shujun Wang
RSRobinson Jeya Shakila
Robinson Jeya Shakila +1
Journal Article
Chitosan is an innate cationic biological polysaccharide polymer, naturally obtained from chitin deacetylation, that possesses broad-spectrum properties such as antibacterial, biodegradability, biocompatibility, non-toxic, non-immunogenicity, and so on. Chitosan can be easily modified owing to its molecular chain that contains abundant active amino and hydroxyl groups, through various modifications. Not only does it possess excellent properties but it also greatly accelerates its solubility and endows it with additional special properties. It can be developed into bioactive materials with innovative properties, functions, and multiple uses, especially in the biomedical fields. In this paper, the unique properties and the relationship between the molecular structure of chitosan and its derivatives are emphasized, an overview of various excellent biomedical properties of chitosan and its current progress in the pharmaceutical and nutraceutical field have prospected, to provide the theoretical basis for better development and utilization of new biomedical materials of chitosan and its derivatives.
Journal Article
MQMingxing Qi
Mingxing QiCZCai Juan Zheng
Cai Juan ZhengWenhui Wu
Guangli YuPWPeipei Wang
Peipei WangThe unique living environment of marine microorganisms endows them with the potential to produce novel chemical compounds with various biological activities. Among them, the exopolysaccharides produced by marine microbes are an important factor for them to survive in these extreme environments. Up to now, exopolysaccharides from marine microbes, especially from extremophiles, have attracted more and more attention due to their structural complexity, biodegradability, biological activities, and biocompatibility. With the development of culture and separation methods, an increasing number of novel exopolysaccharides are being found and investigated. Here, the source, structure and biological activities of exopolysaccharides, as well as their potential applications in environmental restoration fields of the last decade are summarized, indicating the commercial potential of these versatile EPS in different areas, such as food, cosmetic, and biomedical industries, and also in environmental remediation.
About Me
Wenhui Wu, 8 8.1965, Male.
Professor at the College of Food Science and Technology, Shanghai Ocean University; Graduate Student Tutor at the College of Food Science and Technology, Shanghai Ocean University.
Main research areas: marine medicinal chemistry, cardio/cerebral vascular pharmacology.
Present main research: Discovery of fibrinolytic compounds from marine resources and the study of their structure, mechanism, and pharmacological action. Characterization of biological activity, evaluating type I collagen and type Ⅱ collagen from marine resources. Study of marine health foods for special medical purposes.
Education:
1982.9-1986.7: Studied at the Department of Bioengineering, Inner Mongolia Agricultural University, major in Bioengineering, Bachelor of Science.
1986.9-1989.7: Studied at the Department of Bioengineering, Inner Mongolia Agricultural University, major in Bioengineering, Master of Science.
2001.3-2004.9: Studied at the Department of Bioengineering, Tokyo University of Agriculture and Technology, major in Bioengineering, PhD degree.
Work Experience:
2005.6-present: Director, Department of Marine Drug, College of Food Science and Technology, Shanghai Ocean University.
1999.6-2001.2: Worked at the College of Food Science and Engineering, Inner Mongolia Agricultural University.
1998.6-1999.5; Visiting researcher of Food Biotechnology at the Department of Food Science and Technology, Rakuno Gakueen University (Japan).