PubMed^® is an essential resource for the medical domain, but useful concepts are either difficult to extract or are ambiguous, which has significantly hindered knowledge discovery. To address this issue, we constructed a PubMed knowledge graph (PKG) by extracting bio-entities from 29 million PubMed abstracts, disambiguating author names, integrating funding data through the National Institutes of Health (NIH) ExPORTER, collecting affiliation history and educational background of authors from ORCID^®, and identifying fine-grained affiliation data from MapAffil. Through the integration of these credible multi-source data, we could create connections among the bio-entities, authors, articles, affiliations, and funding. Data validation revealed that the BioBERT deep learning method of bio-entity extraction significantly outperformed the state-of-the-art models based on the F1 score (by 0.51%), with the author name disambiguation (AND) achieving an F1 score of 98.09%. PKG can trigger broader innovations, not only enabling us to measure scholarly impact, knowledge usage, and knowledge transfer, but also assisting us in profiling authors and organizations based on their connections with bio-entities.

Heart Rate Variability (HRV) is a significant indicator of physical fitness and mental stresses. Electrocardiography (ECG) is the most common means to detect HRV. However, the nature of the ECG detection limits its convenience and usage time. While wrist-based Photoplethysmography (PPG) provides the possibility of convenient 24/7 HRV monitoring, its accuracy has not been systematically analyzed. We experimented with six healthy subjects and measured PPG from their wrist and ECG from their chest. The result shows that ten HRV parameters have significant differences between stress and non-stress states. Furthermore, the 10-fold accuracy of stress state detection within subjects is 98% and the Leave-One-Participant-Out F1score reaches 80%. The results demonstrate that wrist-based PPG can provide HRV measurements that enable the recognition of mental stress as accurately as ECG, even for a short three-minute temporal window.

This study builds a coronavirus knowledge graph (KG) by merging two information sources. The first source is Analytical Graph (AG), which integrates more than 20 different public datasets related to drug discovery. The second source is CORD-19, a collection of published scientific articles related to COVID-19. We combined both chemo genomic entities in AG with entities extracted from CORD-19 to expand knowledge in the COVID-19 domain. Before populating KG with those entities, we perform entity disambiguation on CORD-19 collections using Wikidata. Our newly built KG contains at least 21,700 genes, 2500 diseases, 94,000 phenotypes, and other biological entities (e.g., compound, species, and cell lines). We define 27 relationship types and use them to label each edge in our KG. This research presents two cases to evaluate the KG’s usability: analyzing a subgraph (ego-centered network) from the angiotensin-converting enzyme (ACE) and revealing paths between biological entities (hydroxychloroquine and IL-6 receptor; chloroquine and STAT1). The ego-centered network captured information related to COVID-19. We also found significant COVID-19-related information in top-ranked paths with a depth of three based on our path evaluation.

Visual question answering is the task of answering questions about images. We introduce the VizWiz-VQA-Grounding dataset, the first dataset that visually grounds answers to visual questions asked by people with visual impairments. We analyze our dataset and compare it with five VQA-Grounding datasets to demonstrate what makes it similar and different. We then evaluate the SOTA VQA and VQA-Grounding models and demonstrate that current SOTA algorithms often fail to identify the correct visual evidence where the answer is located. These models regularly struggle when the visual evidence occupies a small fraction of the image, for images that are higher quality, as well as for visual questions that require skills in text recognition. The dataset, evaluation server, and leaderboard all can be found at the following link: https://vizwiz.org/tasks-and-datasets/answer-grounding-for-vqa/.