This page has only limited features, please log in for full access.

Dr. Mohammad Alomary
King Abdulaziz City for Science and Technololgy (KACST)

Basic Info


Research Keywords & Expertise

0 Cancer
0 Cancer Biology
0 Cancer Cell Biology
0 Cancer Epidemiology
0 Cancer Biomarkers

Fingerprints

Cancer

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
Profile ImageConstantinos Yeles University Magna Graecia of ...
Following: 1 user
View all

Feed

Original research
Published: 01 August 2021 in International Journal of Nanomedicine
Reads 0
Downloads 0

Purpose: 4-Hydroxyisophthalic acid (4-HIA) is a bioactive compound present in the roots of Decalepis hamiltonii, which has attracted considerable attention in attenuating oxidative stress-related neurodegenerative diseases. However, its efficacy is limited because of its low solubility and bioavailability. Therefore, the present study aimed to encapsulate 4-HIA using biocompatible copolymer polylactide-co-glycolide (PLGA) and evaluate its antioxidant and neuroprotective potential. Methods: The nanoparticles (NPs) were fabricated by solid/oil/water (s/o/w) emulsion technique and characterized using XRD, SEM, HR-TEM, and FTIR spectroscopy. Antioxidant assays such as 1,1 diphenyl-2-picrylhydrazyl (DPPH), superoxide, and hydroxyl radical scavenging ability were performed to assess the antioxidant potential of the fabricated NPs. Results: The bioactive component, 4-HIA, was efficiently encapsulated by the PLGA polymer and was found to be spherical and smooth with a size 2O2)-induced cytotoxicity in PC12 cells. Conclusion: Our findings indicate that 4-HIA encapsulated PLGA NPs might be a therapeutic intervention towards the effective management of oxidative stress as it has exhibited efficient neuroprotective potential against H2O2-induced oxidative stress in PC12 cells.

ACS Style

Tekupalli Ravikiran; Santosh Anand; Mohammad Azam Ansari; Mohammad N Alomary; Sami AlYahya; Sowbhagya Ramachandregowda; Saad Alghamdi; Anupama Sindhghatta Kariyappa; Bhagyalakshmi Dundaiah; Mamatha Madhugiri Gopinath; Sumreen Sultana; Shital Manohar Punekar; Thimappa Ramachandrappa Lakshmeesha. Fabrication and in vitro Evaluation of 4-HIA Encapsulated PLGA Nanoparticles on PC12 Cells. International Journal of Nanomedicine 2021, ume 16, 5621 -5632.

AMA Style

Tekupalli Ravikiran, Santosh Anand, Mohammad Azam Ansari, Mohammad N Alomary, Sami AlYahya, Sowbhagya Ramachandregowda, Saad Alghamdi, Anupama Sindhghatta Kariyappa, Bhagyalakshmi Dundaiah, Mamatha Madhugiri Gopinath, Sumreen Sultana, Shital Manohar Punekar, Thimappa Ramachandrappa Lakshmeesha. Fabrication and in vitro Evaluation of 4-HIA Encapsulated PLGA Nanoparticles on PC12 Cells. International Journal of Nanomedicine. 2021; ume 16 ():5621-5632.

Chicago/Turabian Style

Tekupalli Ravikiran; Santosh Anand; Mohammad Azam Ansari; Mohammad N Alomary; Sami AlYahya; Sowbhagya Ramachandregowda; Saad Alghamdi; Anupama Sindhghatta Kariyappa; Bhagyalakshmi Dundaiah; Mamatha Madhugiri Gopinath; Sumreen Sultana; Shital Manohar Punekar; Thimappa Ramachandrappa Lakshmeesha. 2021. "Fabrication and in vitro Evaluation of 4-HIA Encapsulated PLGA Nanoparticles on PC12 Cells." International Journal of Nanomedicine ume 16, no. : 5621-5632.

Review
Published: 18 June 2021 in Cells
Reads 0
Downloads 0

With the increased worldwide burden of cancer, including aggressive and resistant cancers, oncolytic virotherapy has emerged as a viable therapeutic option. Oncolytic herpes simplex virus (oHSV) can be genetically engineered to target cancer cells while sparing normal cells. This leads to the direct killing of cancer cells and the activation of the host immunity to recognize and attack the tumor. Different variants of oHSV have been developed to optimize its antitumor effects. In this review, we discuss the development of oHSV, its antitumor mechanism of action and the clinical trials that have employed oHSV variants to treat different types of tumor.

ACS Style

Norah Aldrak; Sarah Alsaab; Aliyah Algethami; Deepak Bhere; Hiroaki Wakimoto; Khalid Shah; Mohammad Alomary; Nada Zaidan. Oncolytic Herpes Simplex Virus-Based Therapies for Cancer. Cells 2021, 10, 1541 .

AMA Style

Norah Aldrak, Sarah Alsaab, Aliyah Algethami, Deepak Bhere, Hiroaki Wakimoto, Khalid Shah, Mohammad Alomary, Nada Zaidan. Oncolytic Herpes Simplex Virus-Based Therapies for Cancer. Cells. 2021; 10 (6):1541.

Chicago/Turabian Style

Norah Aldrak; Sarah Alsaab; Aliyah Algethami; Deepak Bhere; Hiroaki Wakimoto; Khalid Shah; Mohammad Alomary; Nada Zaidan. 2021. "Oncolytic Herpes Simplex Virus-Based Therapies for Cancer." Cells 10, no. 6: 1541.

Journal article
Published: 16 June 2021 in Antibiotics
Reads 0
Downloads 0

Biofilms not only protect bacteria and Candida species from antibiotics, but they also promote the emergence of drug-resistant strains, making eradication more challenging. As a result, novel antimicrobial agents to counteract biofilm formation are desperately needed. In this study, Terminalia catappa leaf extract (TCE) was used to optimize the TCE-capped silver nanoparticles (TCE-AgNPs) via a one-pot single-step method. Varied concentrations of TCE have yielded different sized AgNPs. The physico-chemical characterization of TCE-AgNPs using UV-Vis, SEM, TEM, FTIR, and Raman spectroscopy have confirmed the formation of nanostructures, their shape and size and plausible role of TCE bio-active compounds, most likely involved in the synthesis as well as stabilization of NPs, respectively. TCE-AgNPs have been tested for antibiofilm and antimicrobial activity against multidrug-resistant Pseudomonas aeruginosa (MDR-PA), methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans using various microbiological protocols. TCE-Ag-NPs−3 significantly inhibits biofilm formation of MDR-PA, MRSA, and C. albicans by 73.7, 69.56, and 63.63%, respectively, at a concentration of 7.8 µg/mL, as determined by crystal violet microtiter assay. Furthermore, SEM micrograph shows that TCE-AgNPs significantly inhibit the colonization and adherence of biofilm forming cells; individual cells with loss of cell wall and membrane integrity were also observed, suggesting that the biofilm architecture and EPS matrix were severely damaged. Moreover, TEM and SEM images showed that TCE-AgNPs brutally damaged the cell wall and membranes of MDR-PA, MRSA, and C. albicans. Additionally, extreme ultrastructural changes such as deformation, disintegration, and separation of cell wall and membrane from the cells, have also been observed, indicating significant loss of membrane and cell wall integrity, which eventually led to cell death. Overall, the research revealed a simple, environmentally friendly, and low-cost method for producing colloidal TCE-AgNPs with promising applications in advanced clinical settings against broad-spectrum biofilm-forming antibiotic-resistant bacteria and candida strains.

ACS Style

Mohammad Ansari; Abul Kalam; Abdullah Al-Sehemi; Mohammad Alomary; Sami AlYahya; Mohammad Aziz; Shekhar Srivastava; Saad Alghamdi; Sultan Akhtar; Hussain Almalki; Syed Adil; Mujeeb Khan; Mohammad Hatshan. Counteraction of Biofilm Formation and Antimicrobial Potential of Terminalia catappa Functionalized Silver Nanoparticles against Candida albicans and Multidrug-Resistant Gram-Negative and Gram-Positive Bacteria. Antibiotics 2021, 10, 725 .

AMA Style

Mohammad Ansari, Abul Kalam, Abdullah Al-Sehemi, Mohammad Alomary, Sami AlYahya, Mohammad Aziz, Shekhar Srivastava, Saad Alghamdi, Sultan Akhtar, Hussain Almalki, Syed Adil, Mujeeb Khan, Mohammad Hatshan. Counteraction of Biofilm Formation and Antimicrobial Potential of Terminalia catappa Functionalized Silver Nanoparticles against Candida albicans and Multidrug-Resistant Gram-Negative and Gram-Positive Bacteria. Antibiotics. 2021; 10 (6):725.

Chicago/Turabian Style

Mohammad Ansari; Abul Kalam; Abdullah Al-Sehemi; Mohammad Alomary; Sami AlYahya; Mohammad Aziz; Shekhar Srivastava; Saad Alghamdi; Sultan Akhtar; Hussain Almalki; Syed Adil; Mujeeb Khan; Mohammad Hatshan. 2021. "Counteraction of Biofilm Formation and Antimicrobial Potential of Terminalia catappa Functionalized Silver Nanoparticles against Candida albicans and Multidrug-Resistant Gram-Negative and Gram-Positive Bacteria." Antibiotics 10, no. 6: 725.

Review
Published: 18 April 2021 in Journal of Fungi
Reads 0
Downloads 0

Rhizosphere-resident fungi that are helpful to plants are generally termed as ‘plant growth promoting fungi’ (PGPF). These fungi are one of the chief sources of the biotic inducers known to give their host plants numerous advantages, and they play a vital role in sustainable agriculture. Today’s biggest challenge is to satisfy the rising demand for crop protection and crop yield without harming the natural ecosystem. Nowadays, PGPF has become an eco-friendly way to improve crop yield by enhancing seed germination, shoot and root growth, chlorophyll production, and fruit yield, etc., either directly or indirectly. The mode of action of these PGPF includes the solubilization and mineralization of the essential micro- and macronutrients needed by plants to regulate the balance for various plant processes. PGPF produce defense-related enzymes, defensive/volatile compounds, and phytohormones that control pathogenic microbes’ growth, thereby assisting the plants in facing various biotic and abiotic stresses. Therefore, this review presents a holistic view of PGPF as efficient natural biofertilizers to improve crop plants’ growth and resistance.

ACS Style

Mahadevamurthy Murali; Banu Naziya; Mohammad Ansari; Mohammad Alomary; Sami AlYahya; Ahmad Almatroudi; M. Thriveni; Hittanahallikoppal Gowtham; Sudarshana Singh; Mohammed Aiyaz; Nataraj Kalegowda; Nanjaiah Lakshmidevi; Kestur Amruthesh. Bioprospecting of Rhizosphere-Resident Fungi: Their Role and Importance in Sustainable Agriculture. Journal of Fungi 2021, 7, 314 .

AMA Style

Mahadevamurthy Murali, Banu Naziya, Mohammad Ansari, Mohammad Alomary, Sami AlYahya, Ahmad Almatroudi, M. Thriveni, Hittanahallikoppal Gowtham, Sudarshana Singh, Mohammed Aiyaz, Nataraj Kalegowda, Nanjaiah Lakshmidevi, Kestur Amruthesh. Bioprospecting of Rhizosphere-Resident Fungi: Their Role and Importance in Sustainable Agriculture. Journal of Fungi. 2021; 7 (4):314.

Chicago/Turabian Style

Mahadevamurthy Murali; Banu Naziya; Mohammad Ansari; Mohammad Alomary; Sami AlYahya; Ahmad Almatroudi; M. Thriveni; Hittanahallikoppal Gowtham; Sudarshana Singh; Mohammed Aiyaz; Nataraj Kalegowda; Nanjaiah Lakshmidevi; Kestur Amruthesh. 2021. "Bioprospecting of Rhizosphere-Resident Fungi: Their Role and Importance in Sustainable Agriculture." Journal of Fungi 7, no. 4: 314.

Review
Published: 14 February 2021 in Medicina
Reads 0
Downloads 0

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic and is posing a serious challenge to mankind. As per the current scenario, there is an urgent need for antiviral that could act as a protective and therapeutic against SARS-CoV-2. Previous studies have shown that SARS-CoV-2 is much similar to the SARS-CoV bat that occurred in 2002-03. Since it is a zoonotic virus, the exact source is still unknown, but it is believed bats may be the primary reservoir of SARS-CoV-2 through which it has been transferred to humans. In this review, we have tried to summarize some of the approaches that could be effective against SARS-CoV-2. Firstly, plants or plant-based products have been effective against different viral diseases, and secondly, plants or plant-based natural products have the minimum adverse effect. We have also highlighted a few vitamins and minerals that could be beneficial against SARS-CoV-2.

ACS Style

Syed Ali; Mohammad Ansari; Mohammad Alzohairy; Ahmad Almatroudi; Mohammad Alomary; Saad Alghamdi; Suriya Rehman; Haris Khan. Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2. Medicina 2021, 57, 169 .

AMA Style

Syed Ali, Mohammad Ansari, Mohammad Alzohairy, Ahmad Almatroudi, Mohammad Alomary, Saad Alghamdi, Suriya Rehman, Haris Khan. Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2. Medicina. 2021; 57 (2):169.

Chicago/Turabian Style

Syed Ali; Mohammad Ansari; Mohammad Alzohairy; Ahmad Almatroudi; Mohammad Alomary; Saad Alghamdi; Suriya Rehman; Haris Khan. 2021. "Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2." Medicina 57, no. 2: 169.

Journal article
Published: 09 February 2021 in Pharmaceuticals
Reads 0
Downloads 0

The current study demonstrates the synthesis of fatty acids (FAs) capped silver nanoparticles (AgNPs) using aqueous poly-herbal drug Liv52 extract (PLE) as a reducing, dispersing and stabilizing agent. The NPs were characterized by various techniques and used to investigate their potent antibacterial, antibiofilm, antifungal and anticancer activities. GC-MS analysis of PLE shows a total of 37 peaks for a variety of bio-actives compounds. Amongst them, n-hexadecanoic acid (21.95%), linoleic acid (20.45%), oleic acid (18.01%) and stearic acid (13.99%) were found predominately and most likely acted as reducing, stabilizing and encapsulation FAs in LIV-AgNPs formation. FTIR analysis of LIV-AgNPs shows some other functional bio-actives like proteins, sugars and alkenes in the soft PLE corona. The zone of inhibition was 10.0 ± 2.2–18.5 ± 1.0 mm, 10.5 ± 2.5–22.5 ± 1.5 mm and 13.7 ± 1.0–16.5 ± 1.2 against P. aeruginosa, S. aureus and C. albicans, respectively. LIV-AgNPs inhibit biofilm formation in a dose-dependent manner i.e., 54.4% ± 3.1%—10.12% ± 2.3% (S. aureus), 72.7% ± 2.2%–23.3% ± 5.2% (P. aeruginosa) and 85.4% ± 3.3%–25.6% ± 2.2% (C. albicans), and SEM analysis of treated planktonic cells and their biofilm biomass validated the fitness of LIV-AgNPs in future nanoantibiotics. In addition, as prepared FAs rich PLE capped AgNPs have also exhibited significant (p < 0.05 *) antiproliferative activity against cultured HCT-116 cells. Overall, this is a very first demonstration on employment of FAs rich PLE for the synthesis of highly dispersible, stable and uniform sized AgNPs and their antibacterial, antifungal, antibiofilm and anticancer efficacy.

ACS Style

Mohammad Ansari; Sarah Asiri; Mohammad Alzohairy; Mohammad Alomary; Ahmad Almatroudi; Firdos Khan. Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents. Pharmaceuticals 2021, 14, 139 .

AMA Style

Mohammad Ansari, Sarah Asiri, Mohammad Alzohairy, Mohammad Alomary, Ahmad Almatroudi, Firdos Khan. Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents. Pharmaceuticals. 2021; 14 (2):139.

Chicago/Turabian Style

Mohammad Ansari; Sarah Asiri; Mohammad Alzohairy; Mohammad Alomary; Ahmad Almatroudi; Firdos Khan. 2021. "Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents." Pharmaceuticals 14, no. 2: 139.

Journal article
Published: 08 February 2021 in Molecules
Reads 0
Downloads 0

The study was undertaken to investigate the antioxidant, genotoxic, and cytotoxic potentialities of phyto-fabricated zinc oxide nanoparticles (ZnO-NPs) from Ipomoea obscura (L.) Ker Gawl. aqueous leaf extract. The UV-visible spectral analysis of the ZnO-NPs showed an absorption peak at 304 nm with a bandgap energy of 3.54 eV, which are characteristics of zinc nanoparticles. Moreover, the particles were of nano-size (~24.26 nm) with 88.11% purity and were agglomerated as observed through Scanning Electron Microscopy (SEM). The phyto-fabricated ZnO-NPs offered radical scavenging activity (RSA) in a dose-dependent manner with an IC50 of 0.45 mg mL−1. In addition, the genotoxicity studies of ZnO-NPs carried out on onion root tips revealed that the particles were able to significantly inhibit the cell division at the mitotic stage with a mitotic index of 39.49%. Further, the cytotoxic studies on HT-29 cells showed that the phyto-fabricated ZnO-NPs could arrest the cell division as early as in the G0/G1 phase (with 92.14%) with 73.14% cells showing early apoptotic symptoms after 24 h of incubation. The results of the study affirm the ability of phyto-fabricated ZnO-NPs from aqueous leaf extract of I. obscura is beneficial in the cytotoxic application.

ACS Style

Mahadevamurthy Murali; Satish Anandan; Mohammad Ansari; Mohammad Alzohairy; Mohammad Alomary; Sarah Asiri; Ahmad Almatroudi; M. Thriveni; Sudarshana Singh; Hittanahallikoppal Gowtham; Mohammed Aiyaz; Chandrashekar Srinivasa; Asna Urooj; Kestur Amruthesh. Genotoxic and Cytotoxic Properties of Zinc Oxide Nanoparticles Phyto-Fabricated from the Obscure Morning Glory Plant Ipomoea obscura (L.) Ker Gawl. Molecules 2021, 26, 891 .

AMA Style

Mahadevamurthy Murali, Satish Anandan, Mohammad Ansari, Mohammad Alzohairy, Mohammad Alomary, Sarah Asiri, Ahmad Almatroudi, M. Thriveni, Sudarshana Singh, Hittanahallikoppal Gowtham, Mohammed Aiyaz, Chandrashekar Srinivasa, Asna Urooj, Kestur Amruthesh. Genotoxic and Cytotoxic Properties of Zinc Oxide Nanoparticles Phyto-Fabricated from the Obscure Morning Glory Plant Ipomoea obscura (L.) Ker Gawl. Molecules. 2021; 26 (4):891.

Chicago/Turabian Style

Mahadevamurthy Murali; Satish Anandan; Mohammad Ansari; Mohammad Alzohairy; Mohammad Alomary; Sarah Asiri; Ahmad Almatroudi; M. Thriveni; Sudarshana Singh; Hittanahallikoppal Gowtham; Mohammed Aiyaz; Chandrashekar Srinivasa; Asna Urooj; Kestur Amruthesh. 2021. "Genotoxic and Cytotoxic Properties of Zinc Oxide Nanoparticles Phyto-Fabricated from the Obscure Morning Glory Plant Ipomoea obscura (L.) Ker Gawl." Molecules 26, no. 4: 891.

Full paper
Published: 12 January 2021 in Chemistry - A European Journal
Reads 0
Downloads 0

The biofunctionalized TiO2 NPs, having a size range of 18.42 ± 1.3 nm were synthesized employing single step approach employing Grape seed extract (GSE) mediated proanthocyanins (PACs) polyphenols. The present study purposes to examine the effect of PACs rich GSE corona on (i) the stability and dispersity of GSE‐TiO 2 ‐NPs, their (ii) anti‐proliferative and anti‐biofilm efficacy and (iii) propensity of internalization and reactive oxygen species (ROS) generation in P. aeruginosa and S. saprophyticus strains. The state‐of‐the‐art techniques were used to validate NPs formation. The comparative FTIR spectral analysis demonstrated that PACs linked functional ‐OH groups likely played a central role in Ti 4+ reduction, nucleation, formation and stability of GSE‐TiO 2 ‐NPs. The TEM and ICP‐MS analyses confirmed there was significantly (p < 0.05) enhanced intracellular uptake of GSE‐TiO 2 ‐NPs in tested uropathogens as compare to bare TiO 2 ‐NPs. Correspondingly, compared to bare NPs, GSE‐TiO 2 ‐NPs induced intracellular ROS formation that corresponded well with dose‐dependent inhibitory patterns of cell proliferation and biofilm formation in both the tested strains. Overall, this study demonstrates that ‐OH rich PACs of GSE corona on biogenic TiO 2 ‐NPs maximized the functional stability, dispersity and propensity of penetration into planktonic cells and biofilm matrices; albeit, such unique merits warranted the GSE‐TiO 2 ‐NPs as a novel, functionally stable and efficient antibacterial nanoformulation to combat with UTIs menace in clinical settings

ACS Style

Mohammad N. Alomary; Mohammad Azam Ansari. Proanthocyanin‐Capped Biogenic TiO 2 Nanoparticles with Enhanced Penetration, Antibacterial and ROS Mediated Inhibition of Bacteria Proliferation and Biofilm Formation: A Comparative Approach. Chemistry - A European Journal 2021, 27, 5817 -5829.

AMA Style

Mohammad N. Alomary, Mohammad Azam Ansari. Proanthocyanin‐Capped Biogenic TiO 2 Nanoparticles with Enhanced Penetration, Antibacterial and ROS Mediated Inhibition of Bacteria Proliferation and Biofilm Formation: A Comparative Approach. Chemistry - A European Journal. 2021; 27 (18):5817-5829.

Chicago/Turabian Style

Mohammad N. Alomary; Mohammad Azam Ansari. 2021. "Proanthocyanin‐Capped Biogenic TiO 2 Nanoparticles with Enhanced Penetration, Antibacterial and ROS Mediated Inhibition of Bacteria Proliferation and Biofilm Formation: A Comparative Approach." Chemistry - A European Journal 27, no. 18: 5817-5829.

Chapter
Published: 21 November 2020 in Role of Exosomes in Biological Communication Systems
Reads 0
Downloads 0

A tremendous number of therapeutic molecules and vaccines have been generated in the last few decades. This level of production necessitates an effective and safe drug delivery system (DDS). Designing a DDS for the specific targeting of organs and for passing through the blood-brain barrier remains a challenge. Several drug carriers have been tested, such as silver- and gold-coated nanoparticles, liposomes and exosomes. Among these, exosomes have received much attention due to their natural composition, outstanding safety and efficient crossing of the blood-brain barrier. A considerable number of studies, including clinical trials, have described the use of exosomes as vehicles for several drug constituents, such as proteins, small molecules, ribonucleic acids (RNAs) and deoxyribonucleic acid (DNA). Despite great accomplishments in the application of exosomes, many challenges, such as induced cytotoxicity, undesired interactions and the production of sufficient quantities for clinical use require further research. In the current chapter, a number of issues regarding the use of exosomes for drug delivery are discussed. The composition, characterization and functions of exosomes are reviewed. We focus on exosomes as vehicles for delivering different drug molecules. In addition, the major advantages and disadvantages associated with the use of exosomes as therapeutic drug vehicles are addressed.

ACS Style

Fahad A. Almughem; Abdullah A. Alshehri; Mohammad N. Alomary. Exosomes in Drug Delivery. Role of Exosomes in Biological Communication Systems 2020, 337 -360.

AMA Style

Fahad A. Almughem, Abdullah A. Alshehri, Mohammad N. Alomary. Exosomes in Drug Delivery. Role of Exosomes in Biological Communication Systems. 2020; ():337-360.

Chicago/Turabian Style

Fahad A. Almughem; Abdullah A. Alshehri; Mohammad N. Alomary. 2020. "Exosomes in Drug Delivery." Role of Exosomes in Biological Communication Systems , no. : 337-360.

Journal article
Published: 01 October 2020 in Arabian Journal of Chemistry
Reads 0
Downloads 0

The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that originated in Chinese city of Wuhan has caused around 906,092 deaths and 28,040,853 confirmed cases worldwide (https://covid19.who.int/, 11 September 2020). In a life-threatening situation, where there is no specific and licensed anti-COVID-19 vaccine or medicine available; the repurposed drug might act as a silver bullet. Currently, more than 211 vaccines, 80 antibodies, 31 antiviral drugs, 35 cell-based, 6 RNA-based and 131 other drugs are in clinical trials. It is therefore utter need of the hour to develop an effective drug that can be used for the treatment of COVID-19 before a vaccine can be developed. One of the best-characterized and attractive drug targets among coronaviruses is the main protease (3CLpro). Therefore, the current study focuses on the molecular docking analysis of TAT-peptide47–57 (GRKKRRQRRRP)-conjugated repurposed drugs (i.e., lopinavir, ritonavir, favipiravir, and hydroxychloroquine) with SARS-CoV-2 main protease (3CLpro) to discover potential efficacy of TAT-peptide (TP) - conjugated repurposing drugs against SARS-CoV-2. The molecular docking results validated that TP-conjugated ritonavir, lopinavir, favipiravir, and hydroxychloroquine have superior and significantly enhanced interactions with the target SARS-CoV-2 main protease. In-silico approach employed in this study suggests that the combination of the drug with TP is an excelling alternative to develop a novel drug for the treatment of SARS-CoV-2 infected patients. The development of TP based delivery of repurposing drugs might be an excellent approach to enhance the efficacy of the existing drugs for the treatment of COVID-19. The predictions from the results obtained provide invaluable information that can be utilized for the choice of candidate drugs for in vitro, in vivo and clinical trials. The outcome from this work prove crucial for exploring and developing novel cost-effective and biocompatible TP conjugated anti-SARS-CoV-2 therapeutic agents in immediate future.

ACS Style

Mohammad Azam Ansari; Qazi Mohammad Sajid Jamal; Suriya Rehman; Ahmad Almatroudi; Mohammad A. Alzohairy; Mohammad N. Alomary; Takshashila Tripathi; Ali H. Alharbi; Syed Farooq Adil; Mujeeb Khan; M. Shaheer Malik. TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19. Arabian Journal of Chemistry 2020, 13, 8069 -8079.

AMA Style

Mohammad Azam Ansari, Qazi Mohammad Sajid Jamal, Suriya Rehman, Ahmad Almatroudi, Mohammad A. Alzohairy, Mohammad N. Alomary, Takshashila Tripathi, Ali H. Alharbi, Syed Farooq Adil, Mujeeb Khan, M. Shaheer Malik. TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19. Arabian Journal of Chemistry. 2020; 13 (11):8069-8079.

Chicago/Turabian Style

Mohammad Azam Ansari; Qazi Mohammad Sajid Jamal; Suriya Rehman; Ahmad Almatroudi; Mohammad A. Alzohairy; Mohammad N. Alomary; Takshashila Tripathi; Ali H. Alharbi; Syed Farooq Adil; Mujeeb Khan; M. Shaheer Malik. 2020. "TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19." Arabian Journal of Chemistry 13, no. 11: 8069-8079.

Editorial
Published: 31 August 2020 in Expert Opinion on Drug Delivery
Reads 0
Downloads 0
ACS Style

Mohammad Azam Ansari; Ahmad Almatroudi; Mohammad A. Alzohairy; Sami AlYahya; Mohammad N. Alomary; Hanan A. Al-Dossary; Saad Alghamdi. Lipid-based nano delivery of Tat-peptide conjugated drug or vaccine–promising therapeutic strategy for SARS-CoV-2 treatment. Expert Opinion on Drug Delivery 2020, 17, 1671 -1674.

AMA Style

Mohammad Azam Ansari, Ahmad Almatroudi, Mohammad A. Alzohairy, Sami AlYahya, Mohammad N. Alomary, Hanan A. Al-Dossary, Saad Alghamdi. Lipid-based nano delivery of Tat-peptide conjugated drug or vaccine–promising therapeutic strategy for SARS-CoV-2 treatment. Expert Opinion on Drug Delivery. 2020; 17 (12):1671-1674.

Chicago/Turabian Style

Mohammad Azam Ansari; Ahmad Almatroudi; Mohammad A. Alzohairy; Sami AlYahya; Mohammad N. Alomary; Hanan A. Al-Dossary; Saad Alghamdi. 2020. "Lipid-based nano delivery of Tat-peptide conjugated drug or vaccine–promising therapeutic strategy for SARS-CoV-2 treatment." Expert Opinion on Drug Delivery 17, no. 12: 1671-1674.

Journal article
Published: 06 July 2020 in Biomolecules
Reads 0
Downloads 0

A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1–3 w/v %), EA concentration (X2, 1–3 w/v %) and the dropping time (X3, 10–30 min). The factorial design proposed eight formulations. The optimized EA–Ca pectinate formulation was evaluated for the gastric ulcer index and the oxidative stress parameter determination of gastric mucosa. The results indicated that the optimum EA–Ca pectinate formula significantly improved the gastric ulcer index in comparison with raw EA. The protective effect of the optimized EA–Ca pectinate formula was further indicated by the histopathological features of the stomach. The results of the study indicate that an EA formulation in the form of Ca pectinate beads would be effective for protection against gastric ulcers because of Nonsteroidal anti-inflammatory drugs (NSAID) administration.

ACS Style

Nabil A. Alhakamy; Shaimaa M. Badr-Eldin; Osama A. A. Ahmed; Abdulrahman A. Halwani; Hibah M. Aldawsari; Mohamed A. El-Moselhy; Aliaa Anter; Sara S. Sharkawi; Muhammad H. Sultan; Osama A. A. Madkhali; Muhammed A. Bakhrebah; Mohammad N. Alomary; Wesam H. Abdulaal; Usama A. Fahmy. Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats. Biomolecules 2020, 10, 1006 .

AMA Style

Nabil A. Alhakamy, Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Abdulrahman A. Halwani, Hibah M. Aldawsari, Mohamed A. El-Moselhy, Aliaa Anter, Sara S. Sharkawi, Muhammad H. Sultan, Osama A. A. Madkhali, Muhammed A. Bakhrebah, Mohammad N. Alomary, Wesam H. Abdulaal, Usama A. Fahmy. Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats. Biomolecules. 2020; 10 (7):1006.

Chicago/Turabian Style

Nabil A. Alhakamy; Shaimaa M. Badr-Eldin; Osama A. A. Ahmed; Abdulrahman A. Halwani; Hibah M. Aldawsari; Mohamed A. El-Moselhy; Aliaa Anter; Sara S. Sharkawi; Muhammad H. Sultan; Osama A. A. Madkhali; Muhammed A. Bakhrebah; Mohammad N. Alomary; Wesam H. Abdulaal; Usama A. Fahmy. 2020. "Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats." Biomolecules 10, no. 7: 1006.

Review
Published: 02 July 2020 in Pharmaceutics
Reads 0
Downloads 0

Cystic Fibrosis (CF), an autosomal recessive genetic disease, is caused by a mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). This mutation reduces the release of chloride ions (Cl−) in epithelial tissues, and hyperactivates the epithelial sodium channels (ENaC) which aid in the absorption of sodium ions (Na+). Consequently, the mucus becomes dehydrated and thickened, making it a suitable medium for microbial growth. CF causes several chronic lung complications like thickened mucus, bacterial infection and inflammation, progressive loss of lung function, and ultimately, death. Until recently, the standard of clinical care in CF treatment had focused on preventing and treating the disease complications. In this review, we have summarized the current knowledge on CF pathogenesis and provided an outlook on the current therapeutic approaches relevant to CF (i.e., CFTR modulators and ENaC inhibitors). The enormous potential in targeting bacterial biofilms using antibiofilm peptides, and the innovative therapeutic strategies in using the CRISPR/Cas approach as a gene-editing tool to repair the CFTR mutation have been reviewed. Finally, we have discussed the wide range of drug delivery systems available, particularly non-viral vectors, and the optimal properties of nanocarriers which are essential for successful drug delivery to the lungs.

ACS Style

Fahad A. Almughem; Ahmad M. Aldossary; Essam A. Tawfik; Mohammad N. Alomary; Waleed S. Alharbi; Mohammad Y. Alshahrani; Abdullah A. AlShehri. Cystic Fibrosis: Overview of the Current Development Trends and Innovative Therapeutic Strategies. Pharmaceutics 2020, 12, 616 .

AMA Style

Fahad A. Almughem, Ahmad M. Aldossary, Essam A. Tawfik, Mohammad N. Alomary, Waleed S. Alharbi, Mohammad Y. Alshahrani, Abdullah A. AlShehri. Cystic Fibrosis: Overview of the Current Development Trends and Innovative Therapeutic Strategies. Pharmaceutics. 2020; 12 (7):616.

Chicago/Turabian Style

Fahad A. Almughem; Ahmad M. Aldossary; Essam A. Tawfik; Mohammad N. Alomary; Waleed S. Alharbi; Mohammad Y. Alshahrani; Abdullah A. AlShehri. 2020. "Cystic Fibrosis: Overview of the Current Development Trends and Innovative Therapeutic Strategies." Pharmaceutics 12, no. 7: 616.

Original research
Published: 01 July 2020 in International Journal of Nanomedicine
Reads 0
Downloads 0

Background and Aim: Flibanserin (FLB) is a multifunctional serotonergic agent used for treating hypoactive sexual desire disorder in premenopausal women via oral administration. FLB has a reported limited oral bioavailability of 33% that could be attributed to the drug’s first-pass metabolism. In addition, FLB has a pH-dependent solubility that could be a challenging factor for drug dissolution in the body neutral fluid, and consequently, absorption via mucosal barriers. Thus, this work aims at investigating the potential of utilizing nanostructured lipid carriers (NLCs) to overcome the aforementioned drawbacks and to enhance nose-to-brain drug delivery. Methods: Box-Behnken design was applied to explore the impact of solid lipid % (SL%, X1), liquid lipid % (LL%, X2), and sonication time (ST, X3) on particle size. The optimized NLC formulation was characterized and incorporated into gellan gum in situ gel. The prepared gel was subjected to in vitro drug release, in vivo pharmacokinetic performance, and histopathological assessment in rats. Results: Statistical analysis revealed a significant negative effect for both SL% and ST on NLCs size. In contrast, a significant positive effect was observed for the LL%. The optimized formulation showed spherical shape with vesicular size of 114.63 nm. The optimized FLB-NLC in situ gel exhibited adequate stability and enhanced in vitro release compared to raw FLB control gel. The plasma and brain concentrations of the drug after nasal administration in rats increased by more than 3– 6-fold, respectively, compared to raw FLB in situ gel. In addition, the histopathological studies revealed the absence of any pathological signs. Conclusion: The aforementioned results highlight the safety of FLB-NLC in situ nasal gel and its potential to improve the drug bioavailability and brain delivery.

ACS Style

Usama A Fahmy; Osama Aa Ahmed; Shaimaa M Badr-Eldin; Hibah M Aldawsari; Solomon Z Okbazghi; Zuhair A Awan; Muhammed A Bakhrebah; Mohammad N Alomary; Wesam H Abdulaal; Carlos Medina; Nabil A Alhakamy. Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin. International Journal of Nanomedicine 2020, ume 15, 5253 -5264.

AMA Style

Usama A Fahmy, Osama Aa Ahmed, Shaimaa M Badr-Eldin, Hibah M Aldawsari, Solomon Z Okbazghi, Zuhair A Awan, Muhammed A Bakhrebah, Mohammad N Alomary, Wesam H Abdulaal, Carlos Medina, Nabil A Alhakamy. Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin. International Journal of Nanomedicine. 2020; ume 15 ():5253-5264.

Chicago/Turabian Style

Usama A Fahmy; Osama Aa Ahmed; Shaimaa M Badr-Eldin; Hibah M Aldawsari; Solomon Z Okbazghi; Zuhair A Awan; Muhammed A Bakhrebah; Mohammad N Alomary; Wesam H Abdulaal; Carlos Medina; Nabil A Alhakamy. 2020. "Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin." International Journal of Nanomedicine ume 15, no. : 5253-5264.

Journal article
Published: 30 June 2020 in Biomolecules
Reads 0
Downloads 0

In this work, we aimed to synthesize zinc oxide nanoparticles (ZnONPs) using an aqueous extract of Cassia auriculata leaves (CAE) at room temperature without the provision of additional surfactants or capping agents. The formation of as-obtained ZnONPs was analyzed by UV–visible (ultraviolet) absorption and emission spectroscopy, X-ray photoemission spectroscopy (XPS), X-ray diffraction analysis (XRD), energy dispersive X-ray diffraction (EDX), thermogravimetric analysis/differential thermal analysis (TGA-DTA), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), and selected area electron diffraction (SAED). The XRD results reflect the wurtzite structure of as-prepared ZnONPs, which produced diffraction patterns showing hexagonal phases. The SEM images indicate that the morphology of as-prepared ZnONPs is composed of hexagonal nanostructures with an average diameter of 20 nm. The HR-TEM result shows that the inter-planar distance between two lattice fringes is 0.260 nm, which coincides with the distance between the adjacent (d-spacing) of the (002) lattice plane of ZnO. The fluorescence emission spectrum of ZnONPs dispersed in ethanol shows an emission maximum at 569 nm, revealing the semiconductor nature of ZnO. As-obtained ZnONPs enhanced the tumoricidal property of CAE in MCF-7 breast cancer cells without significant inhibition of normal human breast cells, MCF-12A. Furthermore, we have studied the antibacterial effects of ZnONPs, which showed direct cell surface contact, resulting in the disturbance of bacterial cell integrity.

ACS Style

Kollur Shiva Prasad; Shashanka K. Prasad; Mohammad Azam Ansari; Mohammad A. Alzohairy; Mohammad N. Alomary; Sami Alyahya; Chandrashekar Srinivasa; Mahadevamurthy Murali; Veena Malligere Ankegowda; Chandan Shivamallu. Tumoricidal and Bactericidal Properties of ZnONPs Synthesized Using Cassia auriculata Leaf Extract. Biomolecules 2020, 10, 982 .

AMA Style

Kollur Shiva Prasad, Shashanka K. Prasad, Mohammad Azam Ansari, Mohammad A. Alzohairy, Mohammad N. Alomary, Sami Alyahya, Chandrashekar Srinivasa, Mahadevamurthy Murali, Veena Malligere Ankegowda, Chandan Shivamallu. Tumoricidal and Bactericidal Properties of ZnONPs Synthesized Using Cassia auriculata Leaf Extract. Biomolecules. 2020; 10 (7):982.

Chicago/Turabian Style

Kollur Shiva Prasad; Shashanka K. Prasad; Mohammad Azam Ansari; Mohammad A. Alzohairy; Mohammad N. Alomary; Sami Alyahya; Chandrashekar Srinivasa; Mahadevamurthy Murali; Veena Malligere Ankegowda; Chandan Shivamallu. 2020. "Tumoricidal and Bactericidal Properties of ZnONPs Synthesized Using Cassia auriculata Leaf Extract." Biomolecules 10, no. 7: 982.

Journal article
Published: 17 May 2020 in Antibiotics
Reads 0
Downloads 0

Synthesis of nanoparticles using the plants has several advantages over other methods due to the environmentally friendly nature of plants. Besides being environmentally friendly, the synthesis of nanoparticles using plants or parts of the plants is also cost effective. The present study focuses on the biosynthesis of zinc oxide nanoparticles (ZnO NPs) using the seed extract of Butea monsoperma and their effect on to the quorum-mediated virulence factors of multidrug-resistant clinical isolates of Pseudomonas aeruginosa at sub minimum inhibitory concentration (MIC). The synthesized ZnO NPs were characterized by different techniques, such as Fourier transform infra-red spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), and transmission electron microscopy (TEM). The average size of the nanoparticles was 25 nm as analyzed by TEM. ZnO NPs at sub MIC decreased the production of virulence factors such as pyocyanin, protease and hemolysin for P. aeruginosa (p ≤ 0.05). The interaction of NPs with the P. aeruginosa cells on increasing concentration of NPs at sub MIC levels showed greater accumulation of nanoparticles inside the cells as analyzed by TEM.

ACS Style

Syed Ghazanfar Ali; Mohammad Azam Ansari; Mohammad A. Alzohairy; Mohammad N. Alomary; Mohammad Jalal; Sami Alyahya; Sarah Mousa Maadi Asiri; Haris M. Khan. Effect of Biosynthesized ZnO Nanoparticles on Multi-Drug Resistant Pseudomonas Aeruginosa. Antibiotics 2020, 9, 260 .

AMA Style

Syed Ghazanfar Ali, Mohammad Azam Ansari, Mohammad A. Alzohairy, Mohammad N. Alomary, Mohammad Jalal, Sami Alyahya, Sarah Mousa Maadi Asiri, Haris M. Khan. Effect of Biosynthesized ZnO Nanoparticles on Multi-Drug Resistant Pseudomonas Aeruginosa. Antibiotics. 2020; 9 (5):260.

Chicago/Turabian Style

Syed Ghazanfar Ali; Mohammad Azam Ansari; Mohammad A. Alzohairy; Mohammad N. Alomary; Mohammad Jalal; Sami Alyahya; Sarah Mousa Maadi Asiri; Haris M. Khan. 2020. "Effect of Biosynthesized ZnO Nanoparticles on Multi-Drug Resistant Pseudomonas Aeruginosa." Antibiotics 9, no. 5: 260.

Journal article
Published: 24 April 2020 in Marine Drugs
Reads 0
Downloads 0

This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h. The efficiency of the double coat to target colonic tissues was confirmed using real-time X-ray radiography of iohexol dye. Entrapment efficiency and particle size were used in the characterization of the formula. Cytotoxicity of SMV microparticles against HCT-116 colon cancer cells was significantly improved as compared to raw SMV. Cell cycle analysis by flow cytomeric technique indicated enhanced accumulation of colon cancer cells in the G2/M phase. Additionally, a significantly higher cell fraction was observed in the pre-G phase, which highlighted enhancement of the proapoptotic activity of SMV prepared in the double coat formula. Assessment of annexin V staining was used for confirmation. Cell fraction in early, late and total cell death were significantly elevated. This was accompanied by a significant elevation of cellular caspase 3 activity. In conclusion, SMV-loaded chitosan coated with eudragit S100 formula exhibited improved colon targeting and enhanced cytotoxicity and proapoptotic activity against HCT-116 colon cancer cells.

ACS Style

Nabil A. Alhakamy; Usama A. Fahmy; Osama A. A. Ahmed; Giuseppe Caruso; Filippo Caraci; Hani Z. Asfour; Muhammed A. Bakhrebah; Mohammad N. Alomary; Wesam H. Abdulaal; Solomon Z. Okbazghi; Ashraf B. Abdel-Naim; Basma G. Eid; Hibah M. Aldawsari; Mallesh Kurakula; Amir I. Mohamed. Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity. Marine Drugs 2020, 18, 226 .

AMA Style

Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Giuseppe Caruso, Filippo Caraci, Hani Z. Asfour, Muhammed A. Bakhrebah, Mohammad N. Alomary, Wesam H. Abdulaal, Solomon Z. Okbazghi, Ashraf B. Abdel-Naim, Basma G. Eid, Hibah M. Aldawsari, Mallesh Kurakula, Amir I. Mohamed. Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity. Marine Drugs. 2020; 18 (4):226.

Chicago/Turabian Style

Nabil A. Alhakamy; Usama A. Fahmy; Osama A. A. Ahmed; Giuseppe Caruso; Filippo Caraci; Hani Z. Asfour; Muhammed A. Bakhrebah; Mohammad N. Alomary; Wesam H. Abdulaal; Solomon Z. Okbazghi; Ashraf B. Abdel-Naim; Basma G. Eid; Hibah M. Aldawsari; Mallesh Kurakula; Amir I. Mohamed. 2020. "Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity." Marine Drugs 18, no. 4: 226.

Review
Published: 24 April 2020 in Current Pharmaceutical Design
Reads 0
Downloads 0

: Nanoparticles (NPs) are unique may be organic or inorganic, play a vital role in the development of drug delivery targeting the central nervous system (CNS). Intranasal drug delivery has shown to be an efficient strategy with attractive application for drug delivery to the CNS related diseases, such as Parkinson's disease, Alzheimer 's disease and brain solid tumors. Blood brain barrier (BBB) and blood-cerebrospinal fluid barriers are natural protective hindrances for entry of drug molecules into the CNS. Nanoparticles exhibit excellent intruding capacity for therapeutic agents and overcome protective barriers. By using nanotechnology based NPs targeted, drug delivery can be improved across BBB with discharge drugs in a controlled manner. NPs confer safe from degradation phenomenon. Several kinds of NPs are used for nose to the brain (N2B) enroute, such as lipidemic nanoparticles, polymeric nanoparticles, inorganic NPs, solid lipid NPs, dendrimers. Among them, popular lipidemic and polymeric NPs are discussed, and their participation in anti-cancer activity has also been highlighted in this review.

ACS Style

Mohammad Azam Ansari; Ill-Min Chung; Govindasamy Rajakumar; Mohammad A. Alzohairy; Mohammad Alomary; Muthu Thiruvengadam; Faheem H. Pottoo; Niyaz Ahmad. Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review. Current Pharmaceutical Design 2020, 26, 1128 -1137.

AMA Style

Mohammad Azam Ansari, Ill-Min Chung, Govindasamy Rajakumar, Mohammad A. Alzohairy, Mohammad Alomary, Muthu Thiruvengadam, Faheem H. Pottoo, Niyaz Ahmad. Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review. Current Pharmaceutical Design. 2020; 26 (11):1128-1137.

Chicago/Turabian Style

Mohammad Azam Ansari; Ill-Min Chung; Govindasamy Rajakumar; Mohammad A. Alzohairy; Mohammad Alomary; Muthu Thiruvengadam; Faheem H. Pottoo; Niyaz Ahmad. 2020. "Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review." Current Pharmaceutical Design 26, no. 11: 1128-1137.

Journal article
Published: 24 April 2020 in Current Pharmaceutical Design
Reads 0
Downloads 0

: In the recent scenario, nanotechnology-based therapeutics intervention has gained tremendous impetus all across the globe. Nano-based pharmacological intervention of various bioactive compounds has been explored on an increasing scale. Sesquiterpenes are major constituents of essential oils (EOs) present in various plant species which possess intriguing therapeutic potentials. However, owing to their poor physicochemical properties; they have pharmacological limitations. Recent advances in nano-based therapeutic interventions offer various avenues to improve their therapeutic applicability. Reckoning with these, the present review collates various nano-based therapeutic intervention of sesquiterpenes with prospective potential against various debilitating diseases especially cancer. In our viewpoint, considering the burgeoning advancement in the field of nanomedicine; in the near future, the clinical applicability of these nano-formulated sesquiterpenes can be foreseen with great enthusiasm.

ACS Style

Mohammad Azam Ansari; Khan F. Badrealam; Asrar Alam; Saba Tufail; Gulshan Khalique; Mohammad Javed Equbal; Mohammad A. Alzohairy; Ahmad Almatroudi; Mohammad Alomary; Faheem H. Pottoo. Recent Nano-based Therapeutic Intervention of Bioactive Sesquiterpenes: Prospects in Cancer Therapeutics. Current Pharmaceutical Design 2020, 26, 1138 -1144.

AMA Style

Mohammad Azam Ansari, Khan F. Badrealam, Asrar Alam, Saba Tufail, Gulshan Khalique, Mohammad Javed Equbal, Mohammad A. Alzohairy, Ahmad Almatroudi, Mohammad Alomary, Faheem H. Pottoo. Recent Nano-based Therapeutic Intervention of Bioactive Sesquiterpenes: Prospects in Cancer Therapeutics. Current Pharmaceutical Design. 2020; 26 (11):1138-1144.

Chicago/Turabian Style

Mohammad Azam Ansari; Khan F. Badrealam; Asrar Alam; Saba Tufail; Gulshan Khalique; Mohammad Javed Equbal; Mohammad A. Alzohairy; Ahmad Almatroudi; Mohammad Alomary; Faheem H. Pottoo. 2020. "Recent Nano-based Therapeutic Intervention of Bioactive Sesquiterpenes: Prospects in Cancer Therapeutics." Current Pharmaceutical Design 26, no. 11: 1138-1144.

Journal article
Published: 27 February 2020 in Antibiotics
Reads 0
Downloads 0

Plant-based synthesis of eco-friendly nanoparticles has widespread applications in many fields, including medicine. Biofilm—a shield for pathogenic microorganisms—once formed, is difficult to destroy with antibiotics, making the pathogen resistant. Here, we synthesized gold nanoparticles (AuNPs) using the stem of an Ayurvedic medicinal plant, Tinospora cordifolia, and studied the action of AuNPs against Pseudomonas aeruginosa PAO1 biofilm. The synthesized AuNPs were characterized by techniques such as ultraviolet-visible spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, energy-dispersive X-ray diffraction, X-ray diffraction, scanning electron microscopy (SEM), and transmission electron microscopy. The AuNPs were spherically shaped with an average size of 16.1 nm. Further, the subminimum inhibitory concentrations (MICs) of AuNPs (50, 100, and 150 µg/mL) greatly affected the biofilm-forming ability of P. aeruginosa, as observed by crystal violet assay and SEM, which showed a decrease in the number of biofilm-forming cells with increasing AuNP concentration. This was further justified by confocal laser scanning microscopy (CLSM), which showed irregularities in the structure of the biofilm at the sub-MIC of AuNPs. Further, the interaction of AuNPs with PAO1 at the highest sub-MIC (150 µg/mL) showed the internalization of the nanoparticles, probably affecting the tendency of PAO1 to colonize on the surface of the nanoparticles. This study suggests that green-synthesized AuNPs can be used as effective nano-antibiotics against biofilm-related infections caused by P. aeruginosa.

ACS Style

Syed Ghazanfar Ali; Mohammad Azam Ansari; Mohammad A. Alzohairy; Mohammad N. Alomary; Sami Alyahya; Mohammad Jalal; Haris M. Khan; Sarah Mousa Maadi Asiri; Wasim Ahmad; Abbas Ali Mahdi; Ahmed M. El-Sherbeeny; Mohammed A. El-Meligy. Biogenic Gold Nanoparticles as Potent Antibacterial and Antibiofilm Nano-Antibiotics against Pseudomonas aeruginosa. Antibiotics 2020, 9, 100 .

AMA Style

Syed Ghazanfar Ali, Mohammad Azam Ansari, Mohammad A. Alzohairy, Mohammad N. Alomary, Sami Alyahya, Mohammad Jalal, Haris M. Khan, Sarah Mousa Maadi Asiri, Wasim Ahmad, Abbas Ali Mahdi, Ahmed M. El-Sherbeeny, Mohammed A. El-Meligy. Biogenic Gold Nanoparticles as Potent Antibacterial and Antibiofilm Nano-Antibiotics against Pseudomonas aeruginosa. Antibiotics. 2020; 9 (3):100.

Chicago/Turabian Style

Syed Ghazanfar Ali; Mohammad Azam Ansari; Mohammad A. Alzohairy; Mohammad N. Alomary; Sami Alyahya; Mohammad Jalal; Haris M. Khan; Sarah Mousa Maadi Asiri; Wasim Ahmad; Abbas Ali Mahdi; Ahmed M. El-Sherbeeny; Mohammed A. El-Meligy. 2020. "Biogenic Gold Nanoparticles as Potent Antibacterial and Antibiofilm Nano-Antibiotics against Pseudomonas aeruginosa." Antibiotics 9, no. 3: 100.