This study aimed to assess the extent of burnout in Romanian and Moldavian academic physicians and to determine the predictive value of emotional intelligence (EI), coping strategies, work motivation (WM), perceived organizational support (POS), and the socio-demographic characteristics of burnout. Two hundred physicians (40% men, 60% women, mean age = 43.02, SD = 9.91) participated in the study. They were administered the Maslach Burnout Inventory−General Survey, Brief COPE Scale, Multidimensional Work Motivation Scale, Schutte’s Self-Report Emotional Intelligence Test, and Perceived Organizational Support Scale. Mann−Whitney U tests were used to assess the significance of intercountry differences, while hierarchical regressions were performed to investigate the predictive value of the independent variables on burnout. Moldavian participants had significantly lower scores in burnout and amotivation (p < 0.001) and higher scores in EI, POS, and WM (p < 0.001). The main burnout predictors were amotivation (β = 0.388, p < 0.001) and low POS (β = −0.313, p< 0.001) in Moldavian respondents, and WM (intrinsic: β = −0.620, p < 0.001; extrinsic: β = 0.406, p < 0.001) in Romanian participants. Moldavian respondents displayed better adjustment to academic stress. The distribution of burnout predictors suggests better sensitivity of respondents to organizational interventions in Moldova and to individual therapy in Romania. This data could serve to better tailor Public Health interventions addressing burnout in the academic environment.

This study aims to examine the relationship between burnout and dentists’ intentions to change careers during the COVID-19 pandemic. The MBI-Human Services Survey for Medical Personnel—MBI-HSS (MP) was used to measure burnout levels and investigate how they relate to dentists’ intentions to change their profession. The sample included 69 Romanian dentists, 56 of whom were women and 13 of whom were men. Self-reported questionnaires provided to the participants were used to collect the data. Female participants reported higher levels of emotional Exhaustion and Depersonalisation than males. However, there were no substantial differences in Personal Accomplishment levels between genders. As for the intentions to change careers, 41 expressed a clear intention to change their profession, 15 were still determining if they would choose the same speciality, and 28 indicated they would not choose the medical field. The study’s findings provide insight into how dentists’ thoughts about perceived burnout during the COVID-19 pandemic significantly influenced their attitudes regarding their career paths. The results suggest concerns regarding burnout in the dental field and emphasise the necessity for burnout interventions and support services, particularly during healthcare crises. Further research and interventions to mitigate burnout and promote well-being among dentists are needed to ensure the sustainability and quality of dental healthcare services in Romania.

Background/Objectives: Manganese–Curcumin–Triphenylphosphonium (Mn-C-TPP), a complex designed for mitochondrial targeting, was investigated with ascorbate to assess cytotoxicity and associated cellular responses. We hypothesized that Mn-C-TPP would amplify ascorbate-driven oxidative stress and produce synergistic cytotoxicity in susceptible cancer cell lines. Methods: An inverse, control-normalized SYTOX-derived response index (vehicle = 100; staurosporine = 0) was determined after 72 h in HCT116, A549, HepG2, and normal dermal human fibroblasts (NDHFs). H₂O₂-associated luminescence (ROS-Glo), caspase-3/7 activation, and mitochondrial membrane potential were assessed in selected cancer cell lines. Drug interactions were analyzed using SynergyFinder 3.0 (ZIP model). Results: Mn-C-TPP alone reduced the SYTOX-derived response index in HCT116 and HepG2, whereas A549 and NDHF showed smaller changes. Ascorbate enhanced cytotoxicity at selected combinations. In HCT116, 3 µM Mn-C-TPP plus 100 µM ascorbate decreased the SYTOX-derived response index toward the staurosporine reference. HepG2 responded markedly to 3–7 µM Mn-C-TPP with 100–300 µM ascorbate, whereas pronounced A549 responses occurred mainly at 15–30 µM Mn-C-TPP with 100–300 µM ascorbate. Mean ZIP scores were approximately 32, 54, 6, and 10 for HCT116, HepG2, A549, and NDHF, respectively. The NDHF response index remained close to the vehicle reference at lower combination doses but decreased at higher doses. Cellular assays showed increased H₂O₂-associated luminescence with Mn-C-TPP alone and higher mean signals with selected combinations than with ascorbate alone, together with caspase-3/7 activation and mitochondrial depolarization. Conclusions: These findings demonstrate cell-line- and concentration-dependent cytotoxicity and support further investigation of the proposed mitochondrial redox mechanism.

Background: Thiabendazole (TBZ), a benzimidazole with established antifungal and anthelmintic properties, has also been reported to exert antiangiogenic effects relevant to tissue remodeling and chronic inflammatory microenvironments. The present study examined how manganese coordination and cyclodextrin modify the dissolution behavior and endothelial activity of TBZ. Methods: Antiangiogenic potential was assessed through a human umbilical vein endothelial cells (HUVECs) scratch-wound migration assay. Dissolution profiles of TBZ, manganese–thiabendazole (MnTBZ), and MnTBZ/monochlorotriazynil-β-cyclodextrin (MCT-β-CD) formulation were evaluated under biorelevant pH conditions (1.2, 4.5, 6.8, 7.4) using the paddle method. Results: TBZ displayed a more rapid and extensive dissolution at pH 1.2, compared to MnTBZ. Partial dissociation at pH 4.5 modestly improved TBZ availability, while dissolution remained minimal at neutral pH. MCT-β-CD enhanced the solubility of MnTBZ at pH ≥ 6.8. In agreement with these profiles, TBZ exerted the strongest inhibition of endothelial migration, followed by MnTBZ/MCT-β-CD and MnTBZ. Conclusions: Manganese coordination and cyclodextrin formulation modulate both the dissolution behavior and endothelial migration-inhibitory activity of TBZ, suggesting that such formulation approaches may influence the delivery-related and functional properties of benzimidazole derivatives.