Epilepsy seizure prediction paves the way of timely warning for patients to take more active and effective intervention measures. Compared to seizure detection that only identifies the inter-ictal state and the ictal state, far fewer researches have been conducted on seizure prediction because the high similarity makes it challenging to distinguish between the pre-ictal state and the inter-ictal state. In this paper, a novel solution on seizure prediction is proposed using common spatial pattern (CSP) and convolutional neural network (CNN). Firstly, artificial pre-ictal EEG signals based on the original ones are generated by combining the segmented pre-ictal signals to solve the trial imbalance problem between the two states. Secondly, a feature extractor employing wavelet packet decomposition and CSP is designed to extract the distinguishing features in both the time domain and the frequency domain. It can improve overall accuracy while reducing the training time. Finally, a shallow CNN is applied to discriminate between the pre-ictal state and the inter-ictal state. Our proposed solution is evaluated on 23 patient's data from Boston Children's Hospital-MIT scalp EEG dataset by employing a leave-one-out cross-validation, and it achieves a sensitivity of 92.2% and false prediction rate of 0.12/h. Experimental result demonstrates that the proposed approach outperforms most state-of-the-art methods.

Wireless sensor networks (WSNs) have witnessed rapid advancement in medical applications from real-time telemonitoring and computer-assisted rehabilitation to emergency response systems. In this paper, we present the state-of-the-art research from the ubiquity perspective, and discuss the insights as well as vision of future directions in WSN-based healthcare systems. First, we propose a novel tiered architecture that can be generally applied to WSN-based healthcare systems. Then, we analyze the IEEE 802 series standards in the access layer on their capabilities in setting up WSNs for healthcare. We also explore some of the up-to-date work in the application layer, mostly on the smartphone platforms. Furthermore, in order to develop and integrate effective ubiquitous sensing for healthcare (USH), we highlight four important design goals (i.e., proactiveness, transparency, awareness, and trustworthiness) that should be taken into account in future systems.

The current glucose measurement approaches still rely on invasive techniques which are uncomfortable and raise the risk of infection. To facilitate daily care at home, we propose an intelligent, non-invasive blood glucose monitoring system which can differentiate a user's blood glucose level into normal, borderline and warning based on smartphone PPG signals. The main implementation processes of the proposed system include: (1) a novel algorithm for acquiring photoplethysmography (PPG) signals using only smartphone camera videos; (2) a fitting-based sliding window (FSW) algorithm to remove varying degrees of baseline drifts and segment the signal into single periods; (3) extracting characteristic features from the Gaussian functions by comparing PPG signals at different blood glucose levels; (4) categorizing the valid samples into three glucose levels by applying machine learning algorithms. Our proposed system was evaluated on a data set of 80 subjects. Experimental results demonstrate the superiority of our proposed system.

Dementia, a chronic and progressive cognitive declination of brain function caused by disease or impairment, is becoming more prevalent due to the aging population. A major challenge in dementia is achieving accurate and timely diagnosis. In recent years, neuroimaging with computer-aided algorithms have made remarkable advances in addressing this challenge. The success of these approaches is mostly attributed to the application of machine learning techniques for neuroimaging. In this review paper, we present a comprehensive survey of automated diagnostic approaches for dementia using medical image analysis and machine learning algorithms published in the recent years. Based on the rigorous review of the existing works, we have found that, while most of the studies focused on Alzheimer's disease, recent research has demonstrated reasonable performance in the identification of other types of dementia remains a major challenge. Multimodal imaging analysis deep learning approaches have shown promising results in the diagnosis of these other types of dementia. The main contributions of this review paper are as follows. 1) Based on the detailed analysis of the existing literature, this paper discusses neuroimaging procedures for dementia diagnosis. 2) It systematically explains the most recent machine learning techniques and, in particular, deep learning approaches for early detection of dementia.

Keeping track of blood glucose levels non-invasively is now possible due to diverse breakthroughs in wearable sensors technology coupled with advanced biomedical signal processing. However, each user might have different requirements and priorities when it comes to selecting a self-monitoring solution. After extensive research and careful selection, we have presented a comprehensive survey on noninvasive/pain-free blood glucose monitoring methods from the recent five years (2012-2016). Several techniques, from bioinformatics, computer science, chemical engineering, microwave technology, etc., are discussed in order to cover a wide variety of solutions available for different scales and preferences. We categorize the noninvasive techniques into nonsample- and sample-based techniques, which we further grouped into optical, nonoptical, intermittent, and continuous. The devices manufactured or being manufactured for noninvasive monitoring are also compared in this paper. These techniques are then analyzed based on certain constraints, which include time efficiency, comfort, cost, portability, power consumption, etc., a user might experience. Recalibration, time, and power efficiency are the biggest challenges that require further research in order to satisfy a large number of users. In order to solve these challenges, artificial intelligence (AI) has been employed by many researchers. AI-based estimation and decision models hold the future of noninvasive glucose monitoring in terms of accuracy, cost effectiveness, portability, efficiency, etc. The significance of this paper is twofold: first, to bridge the gap between IT and medical field; and second, to bridge the gap between end users and the solutions (hardware and software).