The use of Pumps-as-Turbines (PaTs) to replace hydraulic turbines as energy-recovery units in industrial and civil applications is widening the penetration of hydropower in small-scale plants. PaTs show advantages in terms of installation costs and the availability of solutions. Water Distribution Networks (WDNs) represent a potential application where PaTs can be installed to recover water-pressure energy. In this work, a MATLAB©–Simulink model of a WDN branch located in South-Tyrol (Italy) was developed. The flow rate of the WDN was assessed though a measurement campaign showing high daily variability, which negatively affect PaT performance. To let the machine operate close to the Best Efficiency Point (BEP), four different operating strategies were studied to meet the constraint of a fixed pressure equal to 4 bar downstream the WDN branch, required to supply water to users. A PaT speed control strategy was implemented, granting better exploitation of flow rates even in the presence of high daily fluctuations. Energy recovery was 23% higher than that of the reference thanks to an advanced strategy based on controlling PaT rotational speed when the flow rate is smaller than that of the design, and operating in off-design conditions when flow rate is higher than that of the BEP.