Pulmonary nodule is one of the lung diseases and its early diagnosis and treatment are essential to cure the patient. This paper introduces a deep learning framework to support the automated detection of lung nodules in computed tomography (CT) images. The proposed framework employs VGG-SegNet supported nodule mining and pre-trained DL-based classification to support automated lung nodule detection. The classification of lung CT images is implemented using the attained deep features, and then these features are serially concatenated with the handcrafted features, such as the Grey Level Co-Occurrence Matrix (GLCM), Local-Binary-Pattern (LBP) and Pyramid Histogram of Oriented Gradients (PHOG) to enhance the disease detection accuracy. The images used for experiments are collected from the LIDC-IDRI and Lung-PET-CT-Dx datasets. The experimental results attained show that the VGG19 architecture with concatenated deep and handcrafted features can achieve an accuracy of 97.83% with the SVM-RBF classifier.

J. R. Mohanty1 & Swati Samantaray2 1Professor, School of Computer Applications, KIIT University, Bhubaneswar. ORCID: 0000-0002-8762-3037.Email: jnyana1@gmail.com 2Associate Professor, School of Humanities, KIIT University, Bhubaneswar. ORCID: 0000-0002-4823-9278. Email: swati.sray@gmail.com Volume…