Introduction: Nutraceuticals are food or parts of a food that provide medicinal or health benefits, including the prevention and treatment of disease.

Freshwater fish skin and bones are usually by-products of the fish processing industry.

The aim of this study was to evaluate the photoprotective effect of fish bone-derived peptides (FBDPs) in a culture of UV-B-irradiated mouse fibroblasts and their anti-inflammatory activity in a model of stimulated human macrophages. The results showed that cell viability of FBDPs-treated and irradiated fibroblasts was higher than that of irradiated cells, as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and lactate dehydrogenase (LDH) assay, after 25 and 60 s of treatment. Moreover, secretion of interleukin 1-beta (IL-1β) was decreased in FBDPs-treated inflamed macrophages, as determined by ELISA assay.