The success of cancer hyperthermia (HT) treatments is strongly dependent on the temperatures achieved in the tumor and healthy tissues as it correlates with treatment efficacy and safety, respectiv...

The estimation of electrical properties of living biological tissues is relevant to several medical applications ranging from hyperthermia treatment planning to dosimetry and, more in general, is pivotal for a fundamental understanding of bioelectromagnetic interactions. Non-invasive electromagnetic imaging, either based on the processing of electric fields measured via microwave tomography or magnetic fields acquired in magnetic resonance is suitable to pursue this goal. In this framework, the possibility of imaging without the need of phase information would be extremely relevant, as it would enable simpler and more reliable devices and would avoid limiting assumptions typically used in the literature. With reference to the canonical yet significant 2D case, in this paper we propose an inverse scattering approach for tissue characterization from only-amplitude electromagnetic data, which, by virtue of a unified mathematical framework, is viable for both microwave tomography and magnetic resonance imaging. The key feature of the method is the innovative use of morphological maps derived by other medical imaging modalities as prior spatial information. In particular, these images are exploited to define a convenient and effective patient-specific representation of the unknowns. The approach is tested against simulated data derived from anatomically realistic scenarios.

Due to the plethora of possible applicative fall-outs, in the recent years several efforts have been made to develop 3-D field intensity shaping methods. While many approaches able to focus a wave-field into a target point are available, a few strategies have been instead developed to generate a field having a given intensity distribution, which is probably due the higher challenging nature of the problem. In this paper, with reference to scalar fields, we present an innovative 3-D shaping procedure which casts the problem as the solution of a finite number of convex programming problems. The reliability of the proposed procedure has been tested in an 3-D inhomogeneous scenario, showing the possibility of ensuring the uniformity of the field intensity into a target area while keeping it arbitrarily bounded elsewhere.

Clinical trials have shown that hyperthermia is a potent adjuvant to conventional cancer treatments, but the temperatures currently achieved in the clinic are still suboptimal. Hyperthermia treatment planning simulations have potential to improve the heating profile of phased-array applicators. An important open challenge is the development of an effective optimization procedure that enables uniform heating of the target region while keeping temperature below a threshold in healthy tissues. In this work, we analyzed the effectiveness and efficiency of a recently proposed optimization approach, i.e. focusing via constrained power optimization (FOCO), using 3D simulations of twelve clinical patient specific models. FOCO performance was compared against a clinically used particle swarm based optimization approach. Evaluation metrics were target coverage at the 25% iso-SAR level, target hotspot quotient, median target temperature (T50) and computational requirements. Our results show that, on average, constrained power focusing performs slightly better than the clinical benchmark ([Formula: see text]T50 [Formula: see text] °C), but outperforms this clinical benchmark for large target volumes ([Formula: see text]40 cm[Formula: see text], [Formula: see text]T50 [Formula: see text] °C). In addition, the results are achieved in a shorter time ([Formula: see text]%) and are repeatable because the approach is formulated as a convex optimization problem.

Generating given 3-D field intensity distributions in a non homogeneous scenario is a canonical problem which is of interest in many applications. On the other side, due to its very challenging nature, very few methods have been proposed up to now in the literature. In this work, starting from the wellknown time reversal technique, a simple innovative approach, the so-called optimized multi-target time reversal, is presented. The strategy is based on the optimization of the phase shifts between the time-reversed fields in a number of control points within the target region. In doing so, the proposed method outperforms the simple juxtaposition of time-reversed fields pursued by the so-called multi-target time reversal, or even succeed in cases in which the latter fails completely. This capability of the proposed method is assessed through a numerical analysis concerned with a 3-D inhomogeneous scenario, in which the results are quantitatively appraised in terms of coverage of the target areas.

Clinical outcome of hyperthermia depends on the achieved target temperature, therefore target conformal heating is essential. Currently, invasive temperature probe measurements are the gold standard for temperature monitoring, however, they only provide limited sparse data. In contrast, magnetic resonance thermometry (MRT) provides unique capabilities to non-invasively measure the 3D-temperature. This study investigates MRT accuracy for MR-hyperthermia hybrid systems located at five European institutions while heating a centric or eccentric target in anthropomorphic phantoms with pelvic and spine structures. Scatter plots, root mean square error (RMSE) and Bland–Altman analysis were used to quantify accuracy of MRT compared to high resistance thermistor probe measurements. For all institutions, a linear relation between MRT and thermistor probes measurements was found with R² (mean ± standard deviation) of 0.97 ± 0.03 and 0.97 ± 0.02, respectively for centric and eccentric heating targets. The RMSE was found to be 0.52 ± 0.31 °C and 0.30 ± 0.20 °C, respectively. The Bland-Altman evaluation showed a mean difference of 0.46 ± 0.20 °C and 0.13 ± 0.08 °C, respectively. This first multi-institutional evaluation of MR-hyperthermia hybrid systems indicates comparable device performance and good agreement between MRT and thermistor probes measurements. This forms the basis to standardize treatments in multi-institution studies of MR-guided hyperthermia and to elucidate thermal dose-effect relations.