Radiotherapy is now recognized as a pillar in the fight against cancer. Two different types are currently used in clinical practice: (1) external beam radiotherapy, using high-energy X-rays or electron beams, both in the MeV-range, and (2) intraoperative radiotherapy, using low-energy X-rays (up to 50 keV) and MeV-range electron beams. Versatile detectors able to measure the radiation dose independently from the radiation nature and energy are therefore extremely appealing to medical physicists. In this work, a dosimeter based on a high-quality single-crystal synthetic diamond sample was designed, fabricated and characterized under low-energy X-rays, as well as under high-energy pulsed X-rays and electron beams, demonstrating excellent linearity with radiation dose and dose-rate. Detector sensitivity was measured to be 0.299 ± 0.002 µC/Gy under 6 MeV X-ray photons, and 0.298 ± 0.004 µC/Gy under 6 MeV electrons, highlighting that the response of the diamond dosimeter is independent of the radiation nature. Moreover, in the case of low-energy X-rays, an extremely low limit of detection (23 nGy/s) was evaluated, pointing out the suitability of the device to radiation protection dosimetry.

The widespread diffusion of precision radiotherapy techniques, geared toward the release of larger dose gradients in shorter time frames, is leading to new challenges in dosimetry. Accurate dose measurements are essential to check for beam anomalies and inaccuracies to ensure treatment efficacy and patient safety during radiotherapy. This work describes the main features of a diamond dosimeter coupled to an extremely compact front-end electronics. The detection system was tested under the X-ray pulses generated by a medical LINAC for both the 6 MV and the 18 MV accelerating voltages. Located in the LINAC’s bunker, it eliminates the need for a long cable connection between the detector and the electronics, detrimental for the system response speed. Signal acquisition was performed synchronously with the impinging X-ray pulses with a sampling period as low as 20 μs, allowing for a real-time beam monitoring. The dosimeter demonstrated a very good stability despite the high value of the absorbed dose during the performed experiments (~100 Gy). The measured dose-per-pulse values of 278 μGy and 556 μGy at 6 MV and 18 MV, respectively, are in excellent agreement with the nominal values expected for the LINAC apparatus used for the tests. In addition to single-pulse measurements, fundamental for dynamic radiotherapy, the proposed system also allows for the calculation of both the total collected charge and the photocurrent generated by the detector. In this regard, despite the compactness, it demonstrates its effectiveness as a tool for source diagnostics in terms of both beam intensity and emission timing.

One of the goals of modern dynamic radiotherapy treatments is to deliver high-dose values in the shortest irradiation time possible. In such a context, fast X-ray detectors and reliable front-end readout electronics for beam diagnostics are crucial to meet the necessary quality assurance requirements of care plans. This work describes a diamond-based detection system able to acquire and process the dose delivered by every single pulse sourced by a linear accelerator (LINAC) generating 6-MV X-ray beams. The proposed system is able to measure the intensity of X-ray pulses in a limited integration period around each pulse, thus reducing the inaccuracy induced by unnecessarily long acquisition times. Detector sensitivity under 6-MV X-photons in the 0.1–10 Gy dose range was measured to be 302.2 nC/Gy at a bias voltage of 10 V. Pulse-by-pulse measurements returned a charge-per-pulse value of 84.68 pC, in excellent agreement with the value estimated (but not directly measured) with a commercial electrometer operating in a continuous integration mode. Significantly, by intrinsically holding the acquired signal, the proposed system enables signal processing even in the millisecond period between two consecutive pulses, thus allowing for effective real-time dose-per-pulse monitoring.

Thin polycrystalline diamond films chemically vapor deposited on thinned silicon substrates were used as membranes for pressure sensor fabrication by means of selective chemical etching of silicon. The sensing element is based on a simple low-finesse Fabry–Pérot (FP) interferometer. The FP cavity is defined by the end-face of a single mode fiber and the diamond diaphragm surface. Hence, pressure is evaluated by measuring the cavity length by an optoelectronic system coupled to the single mode fiber. Exploiting the excellent properties of Chemical Vapor Deposition (CVD) diamond, in terms of high hardness, low thermal expansion, and ultra-high thermal conductivity, the realized sensors have been characterized up to 16.5 MPa at room temperature. Preliminary characterizations demonstrate the feasibility of such diamond-on-Si membrane structure for pressure transduction. The proposed sensing system represents a valid alternative to conventional solutions, overcoming the drawback related to electromagnetic interference on the acquired weak signals generated by standard piezoelectric sensors.

A single-crystal diamond sample grown by high-pressure high-temperature (HPHT) technique was used for the fabrication of a metal–semiconductor–metal (MSM) photoconductor. The sample quality was evaluated by means of spectral photocurrent measurements highlighting the presence of a significant density of defect states within the diamond bandgap, responsible for trap-mediated conduction mechanisms. The photoconductor was fully characterized under 6 MeV pulsed X-rays, sourced by a medical linear accelerator (LINAC), in the 0.05–20 Gy and 0.017–0.100 Gy/s dose (D) and dose-rate (DR) ranges, respectively. Photocurrent measurements performed with a conventional precision electrometer showed that the detector performance is strongly affected by charge-trapping phenomena, resulting in a sublinear dependence with the DR (power-law dependence with an exponent of 0.86). Measurements were repeated in the same experimental conditions by coupling the detector to a specifically developed gated integrator, allowing for a synchronous integration of photocurrent pulses (limited to 40 $\mu \text{s}$ ) centered on each impinging X-ray pulse. In this case, the detector photoresponse showed an excellent linearity with both the D and the DR (power-law dependence with 1.0009 ± 0.0004 and 1.009 ± 0.005 exponents, respectively). Significantly, the proposed synchronous integration technique is then able to mitigate the detrimental effect that defects have on detector performance. The proposed method paves, therefore, the way to the exploitation of HPHT diamond as a low-cost alternative to single-crystal chemical vapor deposition (CVD)-diamond for the fabrication of accurate and linear X-ray dosimeters.

Gated integrating measurement method represents a widely used approach when fast, repetitive analogue signals are concerned. In this work a compact synchronized gated-integrator prototype has been realized and preliminary characterized. Front-end electronics is based on the mature high-precision switched-integrator transimpedance-amplifier IVC102 whose output is connected to a precision LT1911 inverting amplifier, whereas analogue-to-digital conversion, as well as timing control circuitry, are performed by a high-efficiency LPC845 microcontroller. Synchronizing signal detection with the external trigger generated in coincidence with a source, the proposed circuitry amplifies and integrates the signal only when the pulse is generated, displaying excellent performances in terms of linearity, sensitivity and signal-to-noise ratio. Hence, the proposed solution represents an affordable alternative to continuous-time regime measurement-techniques, usually adopted in radiation dosimetry where accuracy and sensitivity are strict requirements for treatment quality assurance.