Although various analgesics have been used, postoperative pain remains one of the most troublesome aspects of tonsillectomy for patients. The aim of the present study was to evaluate the effectiveness of premedication using pregabalin compared with placebo (diazepam) on postoperative pain control in patients undergoing tonsillectomy. Forty-eight adult patients were randomly divided into a control group and a pregabalin group. Preoperatively, patients in the control group received 4 mg diazepam orally as placebo, whereas those in the pregabalin group received 300 mg pregabalin orally. All participants were provided with patient-controlled analgesia using fentanyl for 24 hours after surgery. Postoperative pain treatment included acetaminophen 650 mg three times daily for 8 postoperative days. The primary outcome measure was the total amount of patient-controlled fentanyl consumption after tonsillectomy. Secondary outcome measures were the number of injections of ketorolac tromethamine (each 30 mg) requested by patients, pain scores, overall satisfaction scores, drowsiness, nausea, dizziness, headache, and vomiting after the surgery. P < 0.05 was considered statistically significant. The total amount of fentanyl demanded decreased significantly in the pregabalin group (P < 0.001). There were no significant differences in the number of ketorolac tromethamine injections, pain scores, overall satisfaction scores, drowsiness, nausea, dizziness, headache, and vomiting between the two groups. Administration of 300 mg pregabalin prior to tonsillectomy decreases fentanyl consumption compared with that after 4 mg diazepam, without an increased incidence of adverse effects. KCT0001215

Several surgical techniques have been used during tonsillectomy to reduce complications. To assess the effects of pillar suture in conjunction with tonsillectomy as compared to tonsillectomy without suture in children. Two authors independently searched five databases (PubMed, SCOPUS, Embase, the Web of Science, and the Cochrane database) for studies published as recent as December 2018. Of the included studies, we compared tonsillectomy and pillar suture in combination (suture groups) with tonsillectomy alone,without suture, (control group). Postoperative pain intensity and other morbidities (e.g., postoperative bleeding, palatal hematoma, discomfort, and pillar edema) were measured during the postoperative period. Postoperative bleeding [primary (OR = 0.47 [0.27; 0.81]) and secondary (OR = 0.14 [0.02; 0.78]) were significantly decreased in the pillar suture group compared to the control group. There were no significant differences between the two groups in postoperative pain at day 7 (SMD = -0.39 [-0.79; 0.00]), palatal hematoma (OR = 5.00 [0.22; 112.88]), palatal discomfort sensation (OR = 2.62 [0.60; 11.46]), site infection (OR = 5.27 [0.24; 113.35]), and velopharyngeal insufficiency (OR = 2.82 [0.11; 74.51]). By contrast, pillar edema (OR = 9.55 [4.29; 21.29]) was significantly increased in the pillar suture group compared to the control group. Pillar suture combined with tonsillectomy may reduce postoperative bleeding incidence despite increasing pillar edema in pediatric tonsillectomy. Postoperative pain-relief, palatal hematoma, palatal discomfort sensation, site infection, and velopharyngeal insufficiency were not significantly altered compared to tonsillectomy alone. However, further studies are needed to corroborate the results of this study.

Im YH, et al. Allergy Asthma Immunol Res. 2024 May;16(3):279-290. https://doi.org/10.4168/aair.2024.16.3.279

Findings on sleep bruxism (SB) in patients with obstructive sleep apnea syndrome (OSAS) are controversial, and some of these findings have relied on in-laboratory polysomnography (PSG). We aimed to identify the factors associated with SB episodes in 100 patients with OSAS using in-laboratory PSG records. Subjects with OSAS were divided into those with and without SB episodes. We analyzed the differences in patient characteristics and PSG indices. Age, gender, height, weight, body mass index, neck, waist, and hip circumferences, and the rates of hypertension and diabetes mellitus were not significantly different between the two groups. A greater proportion of stage N2 sleep in the total sleep time, longer total sleep time, longer sleep time in a supine position, shorter sleep time in a nonsupine position, lower apnea–hypopnea index (AHI), lower AHI regardless of sleeping position, lower AHI during nonrapid eye movement sleep, and higher mean oxygen saturation level were associated with SB episodes in patients with OSAS. Among these factors, longer sleep time in a supine position remained a statistically significant factor in multivariate analysis. We conclude that longer sleep time in a supine position (especially >280 min) might be associated with SB episodes in patients with OSAS.

Stress or pressure induced by the use of a mandibular advancement device (MAD) to treat sleep-disordered breathing can cause side effects including occlusal changes, pain, and discomfort. In this paper, we describe and use finite element (FE) analysis to evaluate a novel MAD that can reduce the stress and side effects associated with these devices. The MAD includes a protruding part that enables rostral movement of the lower tray, providing a wider upper airway and a supporting shield that helps uniformly distribute the concentrated stress. After assembling the three-dimensional model for the MAD and the upper oral structures, a designated force was applied to evaluate the stress distributions of a conventional MAD and the proposed design. FE analysis showed that the stress applied to the upper front teeth and the gingival area near the upper incisors differed between the newly developed and conventional MAD. Concentrated stress was relieved by inserting such a shield, helping to distribute the stress from the front teeth to the gingival area. Our proposed MAD reduced the concentrated stress on the front teeth by distributing it over the gingival area.