A Lewis acid-mediated domino reaction of acetals derived from aromatic ketones with 2-(het)arylcyclopropane-1,1-diesters has been developed. The reaction provides a convenient approach to cyclopentenes and related polycyclic ring systems.

A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very good yields. Consecutive four-component synthesis of the above mentioned imidates from N-alkylindoles, aromatic aldehydes, aromatic isocyanides and alcohols was also proposed. In addition, it was shown that in the presence of water, aryl(indol-3-yl)methylium tetrafluoroborates reacted with isocyanides to furnish aryl(indol-3-yl)acetamides.

Augmented Reality (AR) technology is emerging as a promising tool in education, offering immersive and interactive learning experiences that enhance students’ understanding of abstract scientific concepts. This quasi-experimental study investigated the impact of AR on student learning outcomes in chemistry topics, including acids, bases, pH, oxides, and salts, among lower secondary students in Vietnam. A total of 191 students participated in the study, divided into two groups: the experimental group (n = 94) received AR-integrated lessons. The control group (n = 97) received instruction through traditional methods, including lectures and discussions. Data were collected at three points: prior to the intervention (Test 0, baseline) to establish group equivalence; during the intervention (Test 1) to monitor interim changes; and after the intervention (Test 2) to evaluate overall impact. These were complemented by semi-structured surveys and interviews to assess students’ academic performance, conceptual understanding, and active engagement in the lessons. Mixed-effects ANCOVA revealed a significant Group × Time interaction, F(1,188) = 9.93, p = .002, partial η² = .050, indicating that the experimental group demonstrated significantly greater improvement than the control group. The large between-group effect size (partial η² = .231) confirms substantial practical significance of the AR intervention. Qualitative findings indicated that the use of AR enhanced students’ motivation, engagement, and conceptual understanding by enabling them to visualize three-dimensional molecular structures and conduct simulated experiments in a safe, controlled environment. Despite challenges such as limited technological infrastructure and the need for specialized teacher training, the study demonstrates that AR holds considerable potential for transforming chemistry education in Vietnam. These findings underscore the importance of continued research, targeted professional development, and supportive policies to optimize the integration of AR into diverse educational settings, ultimately improving students’ interest and learning outcomes.

A multicomponent reaction of isocyanides with aryl(indol-3-yl)methylium salts and amines has been found. A series of aryl(indol-3-yl)acetimidamides was obtained in up to 96% yields. In the case of ethyl isocyanoacetate, the reaction is followed by cyclization to form 3,5-dihydro-4H-imidazol-4-one derivatives.