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Rhanterium epapposum, native to the Arabian Peninsula, is traditionally used to cure skin infections. The objective is to screen the phytochemical content and antimicrobial activity of aqueous, methanol and 80% methanol extracts of aerial parts of R. epapposum. The phytochemical screening of aqueous, methanolic, and 80% methanol extracts of R. epapposum was conducted using gas chromatographymass spectrometry. The antimicrobial activities of the extracts were assessed by well diffusion and microdilution methods. Qualitative phytochemical analysis revealed the presence of 2-methoxy-4-vinylphenol in all three extracts, whereas ethanol, 2-methoxy-, acetate; n-hexadecanoic acid; and 2,3-butanediol are present in higher amount exclusively in the methanol, 80% methanol and aqueous extracts of the aerial parts of R. epapposum, respectively. The highest antibacterial activity was shown by the aqueous extract S. aureus, P. aeruginosa, E. cloacae, and K. pneumoniae, methanolic extract against S. aureus, methicillin-resistant S. aureus, and E. coli, and 80% methanol extract against S. epidermidis, and S. paucimobilis. Interestingly, 80% methanol extracts showed the highest antifungal activity against C. albicans, C. guillermondii, C. vaginalis, C. utilis, and C. tropicalis. The aerial parts of R. epapposum showed broad-spread antimicrobial activity against bacteria and fungi. Especially, the 80% methanol extract showed potent antifungal activity against all the tested fungal strains.
Saravanan Rajendrasozhan; Hani Moll; Mejdi Snoussi; Ramy Romeilah; Emad Shalaby; Kareem Younes; Hossam El-Beltagi. Phytochemical Screening and Antimicrobial Activity of Various Extracts of Aerial Parts of Rhanterium epapposum. Processes 2021, 9, 1351 .
AMA StyleSaravanan Rajendrasozhan, Hani Moll, Mejdi Snoussi, Ramy Romeilah, Emad Shalaby, Kareem Younes, Hossam El-Beltagi. Phytochemical Screening and Antimicrobial Activity of Various Extracts of Aerial Parts of Rhanterium epapposum. Processes. 2021; 9 (8):1351.
Chicago/Turabian StyleSaravanan Rajendrasozhan; Hani Moll; Mejdi Snoussi; Ramy Romeilah; Emad Shalaby; Kareem Younes; Hossam El-Beltagi. 2021. "Phytochemical Screening and Antimicrobial Activity of Various Extracts of Aerial Parts of Rhanterium epapposum." Processes 9, no. 8: 1351.
Due to the excessive impact of synthetic drugs, unravelling and employing safe, natural alternatives are now needed to resolve a number of diseases. In this research, we have evaluated hepatoprotective and antioxidant activities of Spirulina platensis and pomegranate juice in rats against hepatotoxicity induced by carbon tetrachloride (CCl4). Spirulina crude carotenoid extract was screened by UPLC-MS / MS. Activities of liver marker enzymes; measured aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and determined lipid peroxidation and antioxidant status as reduced glutathione (GSH) in liver homogenate. The infusion of CCl4 (2 ml/kg b.wt) greatly increases levels of liver marker enzymes and lipid peroxidation, resulting in depletion of antioxidants. Treatment of Spirulina platensis (Sp), pomegranate juice (Pj)or mixture (PJSP) of Spirulina water extract 10% and pomegranate juice 90% (1 ml/100 g b.wt) to CCl4-disrupted rats resulted in decreased activity of liver marker enzymes, lipid peroxidation with increased antioxidant status. Chromatographic separation showed that ß-carotene is the predominant carotenoid extract. This carotenoid extract was tested for colon carcinoma (HCT-116), liver carcinoma (HepG2) and intestinal carcinoma cell lines (CACO) LC50 for 21.8, 14 and 11.3 ug / ml, respectively. Total phenolic phytochemicals, total carotenoids and total flavonoids were also measured in Spirulina. Our study clearly demonstrates that Spirulina platensis and pomegranate juice had hepatoprotective effect on CCl4-caused hepatotoxicity in rats through its antioxidant activity.
Hossam S. El-Beltagi; Faten Dhawi; Ihab S. Ashoush; Khaled Ramadan. Antioxidant, anti-cancer and ameliorative activities of Spirulina platensis and pomegranate juice against hepatic damage induced by CCl4. Notulae Botanicae Horti Agrobotanici Cluj-Napoca 2020, 48, 1941 -1956.
AMA StyleHossam S. El-Beltagi, Faten Dhawi, Ihab S. Ashoush, Khaled Ramadan. Antioxidant, anti-cancer and ameliorative activities of Spirulina platensis and pomegranate juice against hepatic damage induced by CCl4. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2020; 48 (4):1941-1956.
Chicago/Turabian StyleHossam S. El-Beltagi; Faten Dhawi; Ihab S. Ashoush; Khaled Ramadan. 2020. "Antioxidant, anti-cancer and ameliorative activities of Spirulina platensis and pomegranate juice against hepatic damage induced by CCl4." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 48, no. 4: 1941-1956.
Propolis (PR) is a resin product of bee colonies that has rich bioactive antioxidant and bactericidal compounds. Endotoxin, a byproduct of bacterial growth, is reported to cause progressive induction of endogenous oxidative stress and has negative impacts on individual health and wellbeing. Hereby, we investigated the ability of PR to alleviate the oxidative stress and immunosuppression imposed by avian pathogenic Escherichia coli using laying hen as a based model. In this study, PR was dietary supplemented to hens for 4 weeks at a concentration of 0.1%. At the beginning of the 4th week of the experiment, hens from control and PR treatment were injected with E. coli (O157:H7; 107 colonies/hen) or saline. The results showed significant (p < 0.05) negative impact of E. coli challenge on antioxidant status, immune response and productive performance. PR supplementation reduced (p < 0.05) inflammation markers levels (tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β)) and plasma corticosterone concentration. The antioxidant status was ameliorated with dietary PR supplementation to challenged hens, showing significant (p < 0.05) reduction in malondialdehyde (MDA) levels and increasing total antioxidant capacity (TAC) concentrations. Cell mediated, as well as, humeral immune response improved significantly (p < 0.05) with dietary PR verified by the enhancement of T- and B-lymphocyte proliferation and the positive respond to phytohemagglutinin (PHA). Leucocyte cells viability increased significantly and the apoptotic factor forkhead box O3 (Foxo3) was reduced with PR supplementation. The current study revealed that dietary PR supplementation can effectively be used as an organic feed additive to overcome the endogenous oxidative stress induced by endotoxins challenge.
Ahmed Abbas; Abdulaziz Alaqil; Hossam El-Beltagi; Hanaa Abd El-Atty; Nancy Kamel. Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation. Antioxidants 2020, 9, 893 .
AMA StyleAhmed Abbas, Abdulaziz Alaqil, Hossam El-Beltagi, Hanaa Abd El-Atty, Nancy Kamel. Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation. Antioxidants. 2020; 9 (9):893.
Chicago/Turabian StyleAhmed Abbas; Abdulaziz Alaqil; Hossam El-Beltagi; Hanaa Abd El-Atty; Nancy Kamel. 2020. "Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation." Antioxidants 9, no. 9: 893.
A 60-day feeding trial was conducted to assess the effects of dietary supplementation with bile salts (BS), lutein (LTN), and their combination on growth, survival, carotenoid content, and antioxidant status of rabbitfish (Siganus rivulatus) larvae. Fish were fed four isonitrogenous (34.39% protein) and isoenergetic (20.57 kJ/g) diets supplemented with BS (0.15 g kg−1), LTN (0.1 g kg−1), BS+LTN (0.15 and 0.1 g kg−1, respectively), and a non-supplemented control diet. The results revealed that fish fed BS+LTN had the highest significant specific growth rate (4.37% day−1), feed efficiency (46.55%), and survival (97.78%). Lutein supplementation improved whole-body protein content, meanwhile, fish fed a BS-supplemented diet had a higher lipid content. The carotenoid deposition was significantly increased with LTN and BS+LTN in skin, muscle, and whole body compared to the control and BS treatment. All dietary supplementation of BS and LTN showed significant improvement in total antioxidant capacity, catalase, and glutathione peroxidase activities. Additionally, LTN alone or BS+LTN significantly reduced malondialdehyde levels by 5.30 and 29.91%, respectively compared to the control. BS supplementation modulated aminopeptidases activities, triglycerides, cholesterol, and increased the activity of pancreatic lipase. Therefore, it could be inferred that dietary supplementation with LTN in combination with BS could improve the growth performance, carotenoid deposition, antioxidant status, lipid digestion, and metabolism of S. rivulatus.
Abdallah Mansour; Mohamed El-Feky; Hossam El-Beltagi; Ahmed Sallam. Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus. Animals 2020, 10, 1643 .
AMA StyleAbdallah Mansour, Mohamed El-Feky, Hossam El-Beltagi, Ahmed Sallam. Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus. Animals. 2020; 10 (9):1643.
Chicago/Turabian StyleAbdallah Mansour; Mohamed El-Feky; Hossam El-Beltagi; Ahmed Sallam. 2020. "Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus." Animals 10, no. 9: 1643.
This study examines the effect of dietary supplementation with Lactobacillus acidophilus (LA) on the cholesterol levels, immune response, and productive performance of laying hens. A total of 216, 40-week-old, commercial Hy-Line brown chicken layers were randomly assigned into four treatment groups (18 birds × three replicates per group) and fed diet supplemented with 0 (control), 1 × 109, 21 × 109, and 31 × 109 colony forming units (CFUs) of Lactobacillus acidophilus (LA) per kg of feed for six consecutive weeks. Results show that plasma triglycerides, low-density lipoprotein (LDL) and total cholesterols became lesser, while high-density lipoprotein (HDL) cholesterol became higher in LA-supplemented groups compared to the control. In addition, a significant reduction occurred in the liver and egg yolk cholesterol by LA supplementation. Moreover, the immunological parameters including antibody titer against sheep red blood cells (SRBCs), phytohemagglutinin (PHA)-wattle swelling test, and T- & B-lymphocyte proliferation were enhanced in laying hens supplemented with LA compared to the control hens. While the heterophil to lymphocyte (H/L) ratio decreased with LA supplementation, indicating low stress conditions in the treated hens. These positive effects for LA were further reflected on the productive performance of laying hens and improved egg production, egg weight, egg mass, and feed efficiency. Our findings indicate that LA probiotic could be recommended in laying hens’ diets for lowering egg yolk cholesterol with positive impacts on health and performance.
Abdulaziz Alaqil; Ahmed Abbas; Hossam El-Beltagi; Hanaa. El-Atty; Gamal Mehaisen; Eman Moustafa. Dietary Supplementation of Probiotic Lactobacillus acidophilus Modulates Cholesterol Levels, Immune Response, and Productive Performance of Laying Hens. Animals 2020, 10, 1588 .
AMA StyleAbdulaziz Alaqil, Ahmed Abbas, Hossam El-Beltagi, Hanaa. El-Atty, Gamal Mehaisen, Eman Moustafa. Dietary Supplementation of Probiotic Lactobacillus acidophilus Modulates Cholesterol Levels, Immune Response, and Productive Performance of Laying Hens. Animals. 2020; 10 (9):1588.
Chicago/Turabian StyleAbdulaziz Alaqil; Ahmed Abbas; Hossam El-Beltagi; Hanaa. El-Atty; Gamal Mehaisen; Eman Moustafa. 2020. "Dietary Supplementation of Probiotic Lactobacillus acidophilus Modulates Cholesterol Levels, Immune Response, and Productive Performance of Laying Hens." Animals 10, no. 9: 1588.
Recently, there is an increasing demand for functional yoghurts by consumer, especially those produced through the incorporation of food of plant origin or its bioactive components. The current research was devoted to formulating functional buffalo yoghurt through the addition of 0.1 and 0.2% of fenugreek (Trigonella foenum-graecum) seed flour (F1 and F2) and Moringa oleifera seed flour (M1 and M2). The effects of fortification were evaluated on physicochemical, total phenolic content (TPC), antioxidant activity (AOA), the viability of yoghurt starter, and sensory acceptability of yoghurts during cold storage. Moringa oleifera seed flour had higher contents of TPC (140.12 mg GAE/g) and AOA (31.30%) as compared to fenugreek seed flour (47.4 mg GAE/g and 19.1%, respectively). Values of TPC and AOA significantly increased in fortified yoghurts, and M2 treatment had the highest values of TPC (31.61, 27.29, and 25.69 mg GAE/g) and AOA (89.32, 83.5, and 80.35%) at 1, 7, and 14 days of storage, respectively. M2 showed significantly higher antibacterial activity against E. coli, S. aureus, L. monocytogenes, and Salmonella spp. and the zones of inhibition were 12.65, 13.14, 17.23 and 14.49 mm, respectively. On the other hand, control yoghurt showed the lowest antibacterial activity and the zones of inhibition were (4.12, 5.21, 8.55, and 8.39 mm against E. coli, S. aureus, L. monocytogenes, and Salmonella spp., respectively). Incorporation of 0.1% and 0.2% of moringa seed flour (M1 and M2) led to a higher content of Ca, P, K, and Fe and lower content of Mg and Zn as compared to F1 and F2, respectively. Thus, it could be concluded that fenugreek and Moringa oleifera seed flour can be exploited in the preparation of functional novel yoghurt.
Faten Dhawi; Hossam S. El-Beltagi; Esmat Aly; Ahmed Hamed. Antioxidant, Antibacterial Activities and Mineral Content of Buffalo Yoghurt Fortified with Fenugreek and Moringa oleifera Seed Flours. Foods 2020, 9, 1157 .
AMA StyleFaten Dhawi, Hossam S. El-Beltagi, Esmat Aly, Ahmed Hamed. Antioxidant, Antibacterial Activities and Mineral Content of Buffalo Yoghurt Fortified with Fenugreek and Moringa oleifera Seed Flours. Foods. 2020; 9 (9):1157.
Chicago/Turabian StyleFaten Dhawi; Hossam S. El-Beltagi; Esmat Aly; Ahmed Hamed. 2020. "Antioxidant, Antibacterial Activities and Mineral Content of Buffalo Yoghurt Fortified with Fenugreek and Moringa oleifera Seed Flours." Foods 9, no. 9: 1157.
In recent years, nutrient management has gained much attention as a way to mitigate heavy metal stress. Silicon (Si) promotes plant defense responses against toxic metal stresses. In this study, we evaluated the effects of silicon (Si) on copper (Cu) toxicity in two flax genotypes (Sakha 1 and Sakha 2) as it relates to plant growth, yield attributes, total chlorophyll, nucleic acid content, enzymatic and non-enzymatic antioxidants, oxidative damage, lipid peroxidation, copper and silicon content, and fatty acid composition. The results showed that Cu (100 and 200 µM) inhibited plant growth and increased Cu accumulation in soil, roots, and shoots. Cu significantly decreased the yield attributes, total chlorophyll by 9.5% and 22% in Sakha 1 and by 22.5% and 29% in Sakha 2, and enhanced the accumulation of non-enzymatic (tocopherol), enzymatic antioxidants such as superoxide dismnutase, peroxidase, ascorbate peroxidase and catalase) and secondary metabolites (phenol and flavonoids). The DNA content significantly decreased in stressed plants with 100 and 200 µM Cu about 22% and 44%, respectively, in Sakha 1 and about 21.6% and 34.7% in Sakha 2, and RNA content also decreased by about 20% and 29%, respectively, in Sakha 1 and by about 2% and 13% in Sakha 2 compared to the control plant. Furthermore, Cu stress accelerated the generation of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2) and induced cellular oxidative injury caused by lipid peroxidation. In parallel, Cu induced a change in the composition of fatty acids, resulting in lower unsaturated fatty acid levels and increased saturated fatty acids (increased saturation/unsaturation ratio for both genotypes). Treating the flax plants with irrigation three times with Si protected the plants from Cu toxicity. Si treatment decreased the uptake and the transport of Cu to the shoots and harvested seeds and promoted plant growth, yield attributes, and antioxidant defense systems by reducing Cu accumulation, lipid peroxidation, and the generation of H2O2. In addition, the alleviation of Cu toxicity correlated with increased Si accumulation in the roots and shoots. In conclusion, Si can be used to improve the resistance of flax plants to Cu toxicity by up-regulating the antioxidant defense system such as superoxide dismutase (SOD), peroxidase (POD), ascorbate peroxidase (APX) and catalase (CAT) and decreasing the oxidative damage caused by reactive oxygen species (ROS).
Hossam El-Beltagi; Mahmoud Sofy; Mohammed Aldaej; Heba Mohamed. Silicon Alleviates Copper Toxicity in Flax Plants by Up-Regulating Antioxidant Defense and Secondary Metabolites and Decreasing Oxidative Damage. Sustainability 2020, 12, 4732 .
AMA StyleHossam El-Beltagi, Mahmoud Sofy, Mohammed Aldaej, Heba Mohamed. Silicon Alleviates Copper Toxicity in Flax Plants by Up-Regulating Antioxidant Defense and Secondary Metabolites and Decreasing Oxidative Damage. Sustainability. 2020; 12 (11):4732.
Chicago/Turabian StyleHossam El-Beltagi; Mahmoud Sofy; Mohammed Aldaej; Heba Mohamed. 2020. "Silicon Alleviates Copper Toxicity in Flax Plants by Up-Regulating Antioxidant Defense and Secondary Metabolites and Decreasing Oxidative Damage." Sustainability 12, no. 11: 4732.
In recent years, the harmful effects of drought stress have been be mitigated by using bioactive compounds such as antioxidants and osmolytes. In this research, pot experiments were carried out to investigate the effects of ascorbic acid, glutathione and proline on alleviating the harmful effect of drought stress in chickpea plants during season 2017. Chickpea plant seeds were soaked in ascorbic acid (0.75 mM), glutathione (0.75 mM), proline (0.75 mM) singly and/or in sequence combinations for 4 h and then planted in pots. The pots were irrigated with water after seven days (to serve as control), after 14 days (moderate drought stress) and after 28 days (severe drought stress). The sequence combination of antioxidants and proline under drought stress has not been studied yet. The results showed significantly decreased in plant growth, yielding characteristics, photosynthetic pigments and soluble protein content in response to moderate and severe drought stress. Moreover, treatment with antioxidants caused increment the antioxidant enzyme activity, non-enzymatic antioxidant (ascorbic acid and glutathione) contents and endogenous proline in stressed and unstressed plants. In conclusion, The sequence combination of antioxidants and proline caused improvement in plant growth under drought stress by up-regulating the antioxidant defense system and osmolyte synthesis.
Hossam S. El-Beltagi; Heba I. Mohamed; Mahmoud R. Sofy. Role of Ascorbic acid, Glutathione and Proline Applied as Singly or in Sequence Combination in Improving Chickpea Plant through Physiological Change and Antioxidant Defense under Different Levels of Irrigation Intervals. Molecules 2020, 25, 1702 .
AMA StyleHossam S. El-Beltagi, Heba I. Mohamed, Mahmoud R. Sofy. Role of Ascorbic acid, Glutathione and Proline Applied as Singly or in Sequence Combination in Improving Chickpea Plant through Physiological Change and Antioxidant Defense under Different Levels of Irrigation Intervals. Molecules. 2020; 25 (7):1702.
Chicago/Turabian StyleHossam S. El-Beltagi; Heba I. Mohamed; Mahmoud R. Sofy. 2020. "Role of Ascorbic acid, Glutathione and Proline Applied as Singly or in Sequence Combination in Improving Chickpea Plant through Physiological Change and Antioxidant Defense under Different Levels of Irrigation Intervals." Molecules 25, no. 7: 1702.
Protein–polysaccharide interactions have been a focus of scientific attention. This study aimed to improve the antioxidant and hepatoprotective effects of buffalo total milk proteins and whey protein hydrolysate (WPH) through noncovalent interactions with Psyllium husk (ispaghula) mucilage (PHM) and Nabq mucilage (NabM). Chemical composition, phenolic content, and antioxidant activities of milk protein–mucilage complexes were explored. The effects of resulting complexes on liver function, hyperlipidemia, and histopathology of the liver in rats fed high-fat diet (HFD) were investigated. The results showed that the complexes exerted significant effect on normalizing tested parameters; WPH–NabM had the most significantly decreased level of malondialdehyde content and the liver histopathological examination proved an improvement in all groups fed with these complexes. These complexes can be used as functional protection elements against the nonalcoholic fatty liver disease. Practical applications PHM, NabM, and their complexes with milk proteins were proved to improve liver function, enhancing most of its measurable parameters and also diminishing the risk of cardiovascular disease. Mice with HFD achieved better health circumstances by combining these ingredients in their diet. Knowing how much these diseases proliferate in the western world and its correlation with high-fat consumption and modern lifestyle, its conjugation with PHM/NabM–MP complexes may reduce the negative impact of unhealthy food intake and, on some parameters, even improving the whole liver function. For that reason, the present study supports and pushes forward the dissemination and consumption of ispaghula or Nabq (the polysaccharides sources) or supplements originating from them. Although many interactions concerning milk proteins have already been analyzed, our study also proposes the interaction with bioactive polysaccharides as useful, opening a field of research aimed at the better application of milk proteins.
Ahmed A. Abd El‐Maksoud; Reda M. S. Korany; Ismail H. Abd El‐Ghany; Hossam S. El‐Beltagi; Gustavo M. Ambrósio F. de Gouveia. Dietary solutions to dyslipidemia: Milk protein–polysaccharide conjugates as liver biochemical enhancers. Journal of Food Biochemistry 2020, 44, e13142 .
AMA StyleAhmed A. Abd El‐Maksoud, Reda M. S. Korany, Ismail H. Abd El‐Ghany, Hossam S. El‐Beltagi, Gustavo M. Ambrósio F. de Gouveia. Dietary solutions to dyslipidemia: Milk protein–polysaccharide conjugates as liver biochemical enhancers. Journal of Food Biochemistry. 2020; 44 (3):e13142.
Chicago/Turabian StyleAhmed A. Abd El‐Maksoud; Reda M. S. Korany; Ismail H. Abd El‐Ghany; Hossam S. El‐Beltagi; Gustavo M. Ambrósio F. de Gouveia. 2020. "Dietary solutions to dyslipidemia: Milk protein–polysaccharide conjugates as liver biochemical enhancers." Journal of Food Biochemistry 44, no. 3: e13142.
Today synthetic food dyes are being used most commonly as food colorant in confectionaries for children. Present study was designed to evaluate effect of tartrazine and chocolate brown as a synthetic color and turmeric, cocoa as a natural color on Swiss albino mice. The rats have been fed on color biscuits and after the acclimation period, rats were divided into 7 groups (5 rats each one). Rats treated with dose level 7.5 mg/kg /day (ADI) in tartrazine and turmeric and 0.15 mg/kg /day (ADI) in chocolate brown and cocoa. The study revealed a highly noticeable decrease in the body weight gain, food intake and feed efficiency in synthetic color of mice compared to the control group, the mixture improvement this effects and non-significant with natural color. A significant increase in the average weight of the major organs liver, spleen, heart, pancreas and kidney of the mice has been increased significantly in synthetic color treated groups with tartrazine and chocolate brown. Total cholesterol level, T-lipid, LDL and vLDL were no significant change in all mice administration color foods, but significant increase in T.G with tartrazine and chocolate brown and has significant decrease in HDL-C with tartrazine and chocolate brown. There was a significant increase in the level of ALT, AST and ALP with tartrazine and chocolate brown while compared to control group. The mixture synthetic and natural color improved the results. Bilirubin levels were significantly increased with tartrazine and chocolate brown.
Emam Abdel-Rahim; Hossam S. El-Beltagi; Rehab F.M. Ali; Abeer A. Amer; Somia M. Mousa. The Effects of Using Synthetic and Natural Color Foods on Lipid Profile and Liver Function in Rats. Notulae Scientia Biologicae 2019, 11, 363 -367.
AMA StyleEmam Abdel-Rahim, Hossam S. El-Beltagi, Rehab F.M. Ali, Abeer A. Amer, Somia M. Mousa. The Effects of Using Synthetic and Natural Color Foods on Lipid Profile and Liver Function in Rats. Notulae Scientia Biologicae. 2019; 11 (4):363-367.
Chicago/Turabian StyleEmam Abdel-Rahim; Hossam S. El-Beltagi; Rehab F.M. Ali; Abeer A. Amer; Somia M. Mousa. 2019. "The Effects of Using Synthetic and Natural Color Foods on Lipid Profile and Liver Function in Rats." Notulae Scientia Biologicae 11, no. 4: 363-367.
A synthetic scenario for functionalization of β-lactoglobulin (βLg) with polymeric units containing caffeic acid (βLg-polyCA) was developed; and all intermediates and final products were structurally confirmed using nuclear magnetic resonance spectroscopy, matrix assisted laser desorption ionization time-of-flight mass spectrometry, and physico-chemically characterized using differential scanning calorimetry and circular dichroism. The antioxidant properties and emulsion stability of βLg, βLg-CA conjugate and βLg-polyCA based systems containing high percentage of fish oil (50%) were evaluated; and βLg-polyCA presented the highest antioxidant and free radical-scavenging activity based on DPPH, ABTS and HS scavenging assays (92.4, 87.92 and 67.35% respectively). Thiobarbituric acid (TBARS) test demonstrated that compared to native βLg, βLg-polyCA afford up 4–5 fold of inhibition of oxidative rancidity and displayed drastic secondary structure changes. Compared to native βLg based emulsions, βLg-polyCA had larger oil droplet sizes, stronger negative zeta potentials (−69.9 mv), narrower size distributions (PDI: 0.22) and less creaming index.
Ahmed A. Abd El-Maksoud; Sampson Anankanbil; Ye Zhou; Ismail H. Abd El-Ghany; Hossam S. El-Beltagi; Chiranjib Banerjee; Steen V. Petersen; Zheng Guo. Grafting phenolics onto milk protein via conjugated polymerization for delivery of multiple functionalities: Synthesis and characterization. Food Chemistry 2019, 301, 125298 .
AMA StyleAhmed A. Abd El-Maksoud, Sampson Anankanbil, Ye Zhou, Ismail H. Abd El-Ghany, Hossam S. El-Beltagi, Chiranjib Banerjee, Steen V. Petersen, Zheng Guo. Grafting phenolics onto milk protein via conjugated polymerization for delivery of multiple functionalities: Synthesis and characterization. Food Chemistry. 2019; 301 ():125298.
Chicago/Turabian StyleAhmed A. Abd El-Maksoud; Sampson Anankanbil; Ye Zhou; Ismail H. Abd El-Ghany; Hossam S. El-Beltagi; Chiranjib Banerjee; Steen V. Petersen; Zheng Guo. 2019. "Grafting phenolics onto milk protein via conjugated polymerization for delivery of multiple functionalities: Synthesis and characterization." Food Chemistry 301, no. : 125298.
Biscuit is one of the most popular processed ready to eat snacks that have possesses several attractive features including wide consumer base, relatively less expensive, more convenient with long shelf-life and have ability to serve as vehicles for important nutrients. It’s usually available in different sizes, tastes and shapes. It can also be enriched or fortified with other ingredients in order to meet specific nutritional or therapeutic needs of consumers. In recent years, numerous studies have shown the potential of utilizing natural plant such as green leafy vegetable in cookies and biscuit production; the potential of amaranthus leaves used as a source of iron and β-carotene inpakora, vada, namakpal, kurmure, biscuit and cake. The present research was carried out to throw the light on the effect of wheat flour and barley flour with natural and synthetic colors to improve chemical composition, the nutritional value and quality characteristics of producing biscuits. The results indicate that that treatment 100% barley flour 72% with turmeric and cocoa as a natural colors recorded a significant increase in the content of protein, ash, minerals such as iron, zinc, potassium, magnesium and some physical analysis like weight, volume, density as well as sensory evaluation. As compared with wheat flour 72% and synthetic color tartrazine ADI 7.5 mg/kg.bw and chocolate brown ADI 0.15 mg/kg.bw. In conclusion, results showed that barley flour improved nutritional quality, physical characteristics and sensory characteristics of produce biscuit with mixture natural and natural color.
Hossam S. El-Beltagi; Abeer A. Amer; Rehab F. M. Ali; Somia M. Mousa; Emam Abdel-Rahim. The Effects of Wheat Flour and Barley Flour on the Quality and Properties of Biscuits Colored with Synthetic and Natural Colorants. Notulae Scientia Biologicae 2019, 11, 30 -38.
AMA StyleHossam S. El-Beltagi, Abeer A. Amer, Rehab F. M. Ali, Somia M. Mousa, Emam Abdel-Rahim. The Effects of Wheat Flour and Barley Flour on the Quality and Properties of Biscuits Colored with Synthetic and Natural Colorants. Notulae Scientia Biologicae. 2019; 11 (1):30-38.
Chicago/Turabian StyleHossam S. El-Beltagi; Abeer A. Amer; Rehab F. M. Ali; Somia M. Mousa; Emam Abdel-Rahim. 2019. "The Effects of Wheat Flour and Barley Flour on the Quality and Properties of Biscuits Colored with Synthetic and Natural Colorants." Notulae Scientia Biologicae 11, no. 1: 30-38.
Physalis peruviana L. belongs to the family Solanaceae and is considered as plant used for treating various diseases. The protective mechanism of Physalis consists of the ability to scavenge reactive oxygen species (ROS) and to enhance the antioxidant system in the human body. The ethanolic extract of Physalis peruviana fruits contains valuable and active compounds such as carotenoids, phenols, flavonoids, tannin, alkaloids, vitamins C, B3 and B6. Therefore, Physalis peruviana extract has antioxidant and antimicrobial activity against gram-positive and gram-negative bacteria. Gram-positive Bacillus cereus demonstrated higher susceptibility than gram-negative Escherichia coli and Pseudomonas typhimureum. Also, the extract showed positive effect on the fungus used (Aspergillus niger and Candida albicans). In addition, high concentrations of Physalis peruviana ethanolic extract (800 µg/ml) exhibited significant anticancer activity against lung (A549) cells but slight effect against colorectal adenocarcinoma (Caco-2) cells.
Hossam S. El-Beltagi; Heba I. Mohamed; Gehan Safwat; Mohammed Gamal; Basma M. H. Megahed. Chemical Composition and Biological Activity of Physalis peruviana L. Gesunde Pflanzen 2019, 71, 113 -122.
AMA StyleHossam S. El-Beltagi, Heba I. Mohamed, Gehan Safwat, Mohammed Gamal, Basma M. H. Megahed. Chemical Composition and Biological Activity of Physalis peruviana L. Gesunde Pflanzen. 2019; 71 (2):113-122.
Chicago/Turabian StyleHossam S. El-Beltagi; Heba I. Mohamed; Gehan Safwat; Mohammed Gamal; Basma M. H. Megahed. 2019. "Chemical Composition and Biological Activity of Physalis peruviana L." Gesunde Pflanzen 71, no. 2: 113-122.
This work investigated the effect of gamma irradiation with different doses (0.0, 2.5, 5 and 10 kGy) on some biochemical parameters, antioxidant and antimicrobial activities of two Egyptian dry date fruit genotypes. Reducing sugars (%) were significantly increased to 65.96% and 68.09% at 5 kGy for Sakouti and Bondoky cultivars, respectively. The dose level 5 kGy showed highest total soluble sugars (84.62% and 87.66%) for Sakouti and Bondoky cultivars, respectively. Bondoky cultivar has higher content of glucose and fructose at dose 5 kGy compared with Sakouti cultivar. Significantly sucrose content in both cultivars was decreased by increasing γ-irradiation dose level. Total phenolic and flavonoid contents were significantly increased at 5 kGy. The highest level (82.85%) of scavenging activity (DPPH %) was recorded at 5 kGy by Sakouti cultivar. Gamma irradiation caused a significant increase in antimicrobial activity of both cultivars against bacterial (Gram+ve and Gram–ve) and fungal strains. Antimicrobial activities against Escherichia coli and Enterobacter Cloacae were more pronounced with Sakouti than Bondoky cultivar. Antifungal activity was stronger than the antibacterial for both cultivars. Results concluded that γ-irradiation enhanced phenolic and flavonoids compounds, the antioxidant activity and antibacterial potentials of the studied two Egyptian date palm fruits.
Hossam S. El-Beltagi; Amina A. Aly; Wael El-Desouky. Effect of Gamma irradiation on some biochemical properties, antioxidant and antimicrobial activities of Sakouti and Bondoky dry dates fruits genotypes. Journal of Radiation Research and Applied Sciences 2019, 12, 437 -446.
AMA StyleHossam S. El-Beltagi, Amina A. Aly, Wael El-Desouky. Effect of Gamma irradiation on some biochemical properties, antioxidant and antimicrobial activities of Sakouti and Bondoky dry dates fruits genotypes. Journal of Radiation Research and Applied Sciences. 2019; 12 (1):437-446.
Chicago/Turabian StyleHossam S. El-Beltagi; Amina A. Aly; Wael El-Desouky. 2019. "Effect of Gamma irradiation on some biochemical properties, antioxidant and antimicrobial activities of Sakouti and Bondoky dry dates fruits genotypes." Journal of Radiation Research and Applied Sciences 12, no. 1: 437-446.
The objective of this research was to examine the response of different X-ray doses to two okra genotypes, Hassawi okra and the commercial Clemenson genotype on germination and biochemical analysis. The two genotypes of the okra were subjected to various X-ray doses (0–100 Gy). The findings have been shown that the low doses of X-ray up to 5 Gy caused a significant increase in all morphological criteria, total pigment, enzymatic (ascorbic acid, glutathione, and anthocyanin) and nonenzymatic antioxidants (ascorbate peroxidase, catalase, and superoxide dismutase) in the two okra genotypes as compared with untreated plants. On the other side, the high doses of X-ray above 5 Gy considerably decreased all the above parameters and significantly increased lipid peroxidation and oxidative damage (hydrogen peroxide and superoxide anion) in the two okra genotypes as compared with untreated plants. In conclusion, the low doses of X-ray caused stimulation effect and may be used to improve plant growth and alleviate the stress effects. Okra Hassawi genotype is more sensitive to X-ray than the other genotype.
Adel A. Rezk; Jameel M. Al-Khayri; Abdulaziz M. Al-Bahrany; Hossam S. El-Beltagi; Heba I. Mohamed. X-ray irradiation changes germination and biochemical analysis of two genotypes of okra (Hibiscus esculentus L.). Journal of Radiation Research and Applied Sciences 2019, 12, 393 -402.
AMA StyleAdel A. Rezk, Jameel M. Al-Khayri, Abdulaziz M. Al-Bahrany, Hossam S. El-Beltagi, Heba I. Mohamed. X-ray irradiation changes germination and biochemical analysis of two genotypes of okra (Hibiscus esculentus L.). Journal of Radiation Research and Applied Sciences. 2019; 12 (1):393-402.
Chicago/Turabian StyleAdel A. Rezk; Jameel M. Al-Khayri; Abdulaziz M. Al-Bahrany; Hossam S. El-Beltagi; Heba I. Mohamed. 2019. "X-ray irradiation changes germination and biochemical analysis of two genotypes of okra (Hibiscus esculentus L.)." Journal of Radiation Research and Applied Sciences 12, no. 1: 393-402.
Higher plants have been utilized worldwide as characteristic drug a long time to cure human diseases. About 80% of individuals globally use plants as safe sources of medication to cure human diseases through completely different medicine system. One of the available indigenous medicinal plants, Ficus sycomorus belongs to the Moraceae family. The plant contains totally different teams of biologically active compounds that square measure chargeable for the biological activity. Ethanolic and ethyl acetate extracts of leaves of Ficus sycomorus contain higher concentrations of total phenols, flavonoids, tannins, alkaloids and steroids than the fruit extracts. Ethanolic extract in both fruits and leaves gave higher concentrations of phytochemical compounds than the ethyl acetate extracts. Therefore, fruit and leaves extract have antioxidant and antimicrobial activity against gram positive, negative bacteria and fungus. Also, the percentage of Liver cell line (HepG2), Colorectal adenocarcinoma (Caco-2) and Breast cell line (MCF-7) viability was decreased with increasing the concentrations of the ethanolic extract of fruits and leaves of Ficus sycomorus. The high concentrations of ethanolic extract of fruits caused high reduction in the viability of cancer cells, especially in Colorectal adenocarcinoma (Caco-2) cell line. In addition, phytochemical compound screened by GC-MS method. In GC-MS analysis, 12 bioactive phytochemical compounds were identified in fruits and 29 bioactive compounds were detected in leaves extract. These totally different active phytochemicals are found to possess a good vary of activities, which can facilitate within the protection against incurable diseases.
Hossam S. El-Beltagi; Heba I. Mohamed; Abdelrahman S. Abdelazeem; Reem Youssef; Gehan Safwat. GC-MS Analysis, Antioxidant, Antimicrobial and Anticancer Activities of Extracts from Ficus sycomorus Fruits and Leaves. Notulae Botanicae Horti Agrobotanici Cluj-Napoca 2018, 47, 493 -505.
AMA StyleHossam S. El-Beltagi, Heba I. Mohamed, Abdelrahman S. Abdelazeem, Reem Youssef, Gehan Safwat. GC-MS Analysis, Antioxidant, Antimicrobial and Anticancer Activities of Extracts from Ficus sycomorus Fruits and Leaves. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2018; 47 (2):493-505.
Chicago/Turabian StyleHossam S. El-Beltagi; Heba I. Mohamed; Abdelrahman S. Abdelazeem; Reem Youssef; Gehan Safwat. 2018. "GC-MS Analysis, Antioxidant, Antimicrobial and Anticancer Activities of Extracts from Ficus sycomorus Fruits and Leaves." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 47, no. 2: 493-505.
The doum palm (Hyphaene thebaica) is a type palm tree which has a wood texture and has edible oval fruits and the origin native to upper Egypt. The trunk of this small palm is dichotomous. It is one of the most important useful plants in the world. All parts of doum palm have a useful role such as fiber and leaflets which used to weave baskets and doum nuts which have antioxidants and secondary metabolites such as tannins, phenols, saponin, steroids, glycosides, flavonoid, terpenes and terpinoids. Also, roots, stems and leaves are used in medicine, ropes and baskets. Studies on anti-inflammatory, antioxidant, antimicrobial, anticancer and pharmacological potential of Hyphaene thebaica extracts and its major phytoconstituents like the phenolic, essential oil and flavonoid compounds are extensively discussed in this review.
Hossam S. El-Beltagi; Heba I. Mohamed; Hany N. Yousef; Eman M. Fawzi. Biological Activities of the Doum Palm (Hyphaene thebaica L.) Extract and Its Bioactive Components. Antioxidants in Foods and Its Applications 2018 .
AMA StyleHossam S. El-Beltagi, Heba I. Mohamed, Hany N. Yousef, Eman M. Fawzi. Biological Activities of the Doum Palm (Hyphaene thebaica L.) Extract and Its Bioactive Components. Antioxidants in Foods and Its Applications. 2018; ():.
Chicago/Turabian StyleHossam S. El-Beltagi; Heba I. Mohamed; Hany N. Yousef; Eman M. Fawzi. 2018. "Biological Activities of the Doum Palm (Hyphaene thebaica L.) Extract and Its Bioactive Components." Antioxidants in Foods and Its Applications , no. : .
Diabetes mellitus type two (T2DM) is one of the most extensive diseases in the world. Herbal therapy remains a possible adjunct therapy to sustain better glycemic control and reduce complications arising from diabetes. In order to evaluate the curative impacts of olive leaf extract (OLE) on streptozotocin (STZ)-induced diabetic rats, twenty-four Wistar male adult rats were divided into four equal groups; control, diabetic control (45 mg/kg STZ), normal rats treated with OLE (17.8 mg/kg b.wt.), and diabetic rats treated with OLE (45 mg/kg STZ + 17.8 mg/kg b.wt.). The OLE extract was investigated for in vitro antioxidant activity using the DPPH• assay. The phenolic, tannin, and flavonoid contents were determined. The activity of GPX, SOD, and GSH in RBC lysate, CAT in plasma and MDA in serum were measured. The OLE prevented the decrease in GSH and kept MDA around the normal range in the treated diabetic rats. The current study suggests that OLE might be used safely to ameliorate T2DM and its accompanying oxidative stress.
A. M.R. Afify; H. S. El-Beltagi; S. A. Fayed; A. E. El-Ansary. In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats. Grasas y Aceites 2018, 69, 243 -e243.
AMA StyleA. M.R. Afify, H. S. El-Beltagi, S. A. Fayed, A. E. El-Ansary. In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats. Grasas y Aceites. 2018; 69 (1):243-e243.
Chicago/Turabian StyleA. M.R. Afify; H. S. El-Beltagi; S. A. Fayed; A. E. El-Ansary. 2018. "In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats." Grasas y Aceites 69, no. 1: 243-e243.
Carissa carandas L. is known in folk medicine for its anti-inflammatory and hepatoprotective activities. Meanwhile it is an evergreen shrub that constitutes a continuous source of leaves throughout the year. The leaves of Carissa carandas L. may be rich in compounds that can be used as safe anti-inflammatory and antioxidant remedies. The combined antioxidant and anti-inflammatory activities provoked the study of the hepatoprotective effects. To isolate major constituents from the leaves of Carissa carandas L. and test their anti-inflammatory and antioxidant activities in-vivo and in-vitro. The leaves of Carissa carandas L. were extracted with 80% MeOH and then defatted with CHCl3 to yield Carissa carandas defatted extract (CCDE). The extract was chemoprofiled using UPLC-MS/MS to stand for major constituents, then subjected to different chromatographic separation steps and naringin (NG) was isolated in a high yield. The anti-inflammatory activity of NG was investigated in-vivo by carrageenan induced hind rat paw edema model at two dose levels (50 and 25 mg/kg). The anti-inflammatory activity was also evaluated in-vitro by measuring its inhibitory effect on LPS induced release of NO from RAW 264.7 macrophages. The antioxidant activity was evaluated by superoxide and DPPH radical scavenging ability. The safety of NG was tested against primary rat hepatocytes. The hepatoprotective effect of CCDE was evaluated by detecting its effects on serum liver function markers and liver cell oxidative stress markers. NG exhibited potent inhibition of inflammation as compared to indomethacin (20 mg/kg). NG inhibited LPS induced release of NO from macrophages (IC50, 6.4 μM). NG showed significant antioxidant activity as it scavenged the superoxide radical (EC90, 10.95 μM) and DPPH radical (EC50, 11.2 μM). CCDE inhibited the elevation of the serum liver marker enzymes and increased GSH and decreased MDA contents in the liver homogenate. Liver histopathology supported the biochemical findings. C. carandas has potent anti-inflammatory, antioxidant and hepatoprotective activities.
Ahmed H. El-Desoky; Rehab F. Abdel-Rahman; Osama K. Ahmed; Hossam S. El-Beltagi; Masao Hattori. Anti-inflammatory and antioxidant activities of naringin isolated from Carissa carandas L.: In vitro and in vivo evidence. Phytomedicine 2018, 42, 126 -134.
AMA StyleAhmed H. El-Desoky, Rehab F. Abdel-Rahman, Osama K. Ahmed, Hossam S. El-Beltagi, Masao Hattori. Anti-inflammatory and antioxidant activities of naringin isolated from Carissa carandas L.: In vitro and in vivo evidence. Phytomedicine. 2018; 42 ():126-134.
Chicago/Turabian StyleAhmed H. El-Desoky; Rehab F. Abdel-Rahman; Osama K. Ahmed; Hossam S. El-Beltagi; Masao Hattori. 2018. "Anti-inflammatory and antioxidant activities of naringin isolated from Carissa carandas L.: In vitro and in vivo evidence." Phytomedicine 42, no. : 126-134.
Multi-functional phenolic emulsifiers were prepared by covalently coupling β-Lactoglobulin (βLg) to caffeic acid (CA) using crosslinker chemistry at different pH conditions (pH 2.5, 6.0, and 8.5). The resulting bioconjugates were characterized by MALDI-TOF MS, differential scanning calorimetry (DSC), fluorescence-quenching, infrared and circular dichroism spectroscopies. Furthermore, the emulsifying and antioxidant properties of βLg-CA conjugates were evaluated and compared to native β-Lactoglobulin and the non-covalent β-lactoglobulin/caffeic complex (βLg/CA). Results showed: 1) An optimal molar ratio (8:1) of caffeic acid to βLg was obtained at pH 6; 2) DPPH activity of βLg-CA increases as the number of CA units coupled increases; 3) βLg-CA conjugates displayed comparable or superior water solubility than native βLg and βLg/CA. Moreover, DSC results showed that coupling of CA with βLg significantly increased the thermal stability of βLg. In summary, βLg-CA conjugates can act as effective antioxidant emulsifiers and stabilizers and may find application in food and cosmetic industries.
Ahmed A. Abd El-Maksoud; Ismail H. Abd El-Ghany; Hossam S. El-Beltagi; Sampson Anankanbil; Chiranjib Banerjee; Steen V. Petersen; Bianca Pérez; Zheng Guo. Adding functionality to milk-based protein: Preparation, and physico-chemical characterization of β-lactoglobulin-phenolic conjugates. Food Chemistry 2018, 241, 281 -289.
AMA StyleAhmed A. Abd El-Maksoud, Ismail H. Abd El-Ghany, Hossam S. El-Beltagi, Sampson Anankanbil, Chiranjib Banerjee, Steen V. Petersen, Bianca Pérez, Zheng Guo. Adding functionality to milk-based protein: Preparation, and physico-chemical characterization of β-lactoglobulin-phenolic conjugates. Food Chemistry. 2018; 241 ():281-289.
Chicago/Turabian StyleAhmed A. Abd El-Maksoud; Ismail H. Abd El-Ghany; Hossam S. El-Beltagi; Sampson Anankanbil; Chiranjib Banerjee; Steen V. Petersen; Bianca Pérez; Zheng Guo. 2018. "Adding functionality to milk-based protein: Preparation, and physico-chemical characterization of β-lactoglobulin-phenolic conjugates." Food Chemistry 241, no. : 281-289.