Pesticide poisoning in pediatric patients is still an important reason for presenting to the emergency department in Romania. In this context, the present study aims to raise awareness of the toxicological impact of pesticides on human health in pediatrics. For this purpose, the demographic characteristics, clinical assessment, and outcome of pediatric patients with acute pesticide poisoning admitted to the toxicology department of “Saint Mary” Emergency Children’s Hospital from Iasi, were analyzed. This retrospective study focused on the clinical and laboratory data of patients aged under 18 years diagnosed with acute pesticide poisoning between 2010–2020. The statistical analysis was performed using the Statistica 10 package. A total of 49 patients presented with manifestations of acute pesticide poisoning, and the most common pesticide involved was diazinon. The most frequent exposure route was accidentally ingesting pesticide products (95%). The primary clinical manifestations were toxic encephalopathy, coma, depressive disorder, gastric disorders, and respiratory failure. Changes in the glycemic status, liver, and kidney damage were also present. Treatment included decontamination, administration of antidote, supportive care, and recommendations to be closely monitored to avoid a new incident. These results highlight the toxic potential of pesticides on human health and their biological consequences, which require an increase in consciousness of the precautions imposed on their use, especially when children are nearby.

Cosmeceutical systems represent next-generation topical platforms designed to deliver bioactive molecules with therapeutic potential directly to the skin. This study evaluated four anti-wrinkle formulations (three creams and one emulgel) in terms of their stability, sensory characteristics, acceptability, and skin tolerance. The products incorporated a unique combination of active ingredients, including N-acetylcysteine, arginine HCl, Blainvillea camellia flower extract, tocopherol, and hyaluronic acid. For the cream formulations (EG01–EG03), different emulsifiers were employed, while EG04 was developed as an emulgel. Stability testing revealed that only three out of four formulations remained physically stable, with EG04 showing phase separation. Sensory analysis assessed parameters such as spreading, absorption, shininess, stickiness, greasiness, and smoothness, with results illustrated using a radar plot. EG01 and EG03 displayed similar sensory profiles, differing mainly in shininess and greasiness, while both exhibited high smoothness. In vivo testing was conducted on female human volunteers aged 50–65 years (Fitzpatrick skin types II–IV) to evaluate tolerance and acceptability. Only EG01 and EG03, formulated with methyl glucose sesquistearate and polyglyceryl-3-methylglucose distearate, respectively, demonstrated both superior sensory performance and 100% acceptability and tolerance in clinical assessment.

Community pharmacy has evolved a lot in recent years in terms of pharmaceutical services and marketing policies applied in Romania. This study aimed to evaluate the degree of patient satisfaction in community pharmacies in Iași, Romania correlated with the frequency of returning to the pharmacy, level of education, gender, and stress level at the time when the pharmacist dispenses the medication. A total of 30 community pharmacies were involved, and in a period of three months, they issued questionnaires to patients. 722 patients responded, and to verify the first research hypothesis, the Pearson correlation was applied. Statistical analysis revealed that there is a negative, medium-level, and significant correlation between the level of satisfaction with pharmaceutical services and the frequency of visits to the pharmacy, r = −0.342, p < 0.0001. There is also a significant, negative correlation of low intensity between the level of satisfaction with pharmaceutical services and patient status, r = −0.202, p < 0.0001. The degree of patient satisfaction is influenced by the quality of the basic pharmaceutical service offered, by the frequency of visits to the pharmacy, by the level of stress, and by social class.

Generally, NSAIDs are weakly soluble in water and contain both hydrophilic and hydrophobic groups. One of the most widely used NSAIDs is ibuprofen, which has a poor solubility and high permeability profile. By creating dynamic, non-covalent, water-soluble inclusion complexes, cyclodextrins (CDs) can increase the dissolution rate of low aqueous solubility drugs, operating as a drug delivery vehicle, additionally contributing significantly to the chemical stability of pharmaceuticals and to reducing drug-related irritability. In order to improve the pharmacological and pharmacokinetics profile of ibuprofen, new thiazolidin-4-one derivatives of ibuprofen (4b, 4g, 4k, 4m) were complexed with β-CD, using co-precipitation and freeze-drying. The new β-CD complexes (β-CD-4b, β-CD-4g, β-CD-4k, β-CD-4m) were characterized using scanning electronic microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction and a phase solubility test. Using the AutoDock-VINA algorithm included in YASARA-structure software, we investigated the binding conformation of ibuprofen derivatives to β-CD and measured the binding energies. We also performed an in vivo biological evaluation of the ibuprofen derivatives and corresponding β-CD complexes, using analgesic/anti-inflammatory assays, as well as a release profile. The results support the theory that β-CD complexes (β-CD-4b, β-CD-4g, β-CD-4k, β-CD-4m) have a similar effect to ibuprofen derivatives (4b, 4g, 4k, 4m). Moreover, the β-CD complexes demonstrated a delayed release profile, which provides valuable insights into the drug-delivery area, focused on ibuprofen derivatives.

Background: The international migration of pharmaceutical professionals has implications for the availability of human resources and the sustainability of pharmaceutical services; however, the determinants of pharmacists’ readiness for cross-border mobility remain insufficiently examined. This study examines the associations of professional factors, the importance assigned to migration-related benefits, and relocation-related barriers with Migration Readiness within the Push–Pull–Mooring (PPM) theoretical framework. Methods: Data were collected via an online questionnaire administered to a sample of 542 professionally active pharmacists in Romania and were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM) with SmartPLS 4. The findings indicate that dissatisfaction with working conditions and remuneration is positively associated with both the Importance of Migration Benefits and Migration Readiness. Greater importance assigned to potential economic, professional, and personal migration-related benefits is, in turn, positively associated with Migration Readiness. Results: Among the mooring factors, Migration Mooring Barriers exhibit the strongest direct association with Migration Readiness, with a negative direction of the relationship; within this construct, family responsibilities and uncertainty regarding adjustment displayed the largest positive relative weights within the formative composite. By contrast, perceived institutional and professional deficits do not display significant associations with either perceived migration benefits or readiness to migrate. In addition, the internal cross-validated predictive assessment yielded positive Q² predict values for both endogenous constructs (Importance of Migration Benefits, IMB = 0.210; Migration Readiness, MR = 0.193). CVPAT indicated significantly lower predictive loss for the PLS-SEM model than for the indicator-mean and linear-model benchmarks, although the predictive advantage over the linear model was modest. These results support the internal predictive performance of the selected model for questionnaire responses within the analyzed sample. They do not establish the model’s ability to predict subsequent migration or monitor workforce vulnerability over time. The model should therefore be regarded as a candidate framework for future longitudinal and externally validated workforce research. Conclusions: The findings provide exploratory support for examining pharmacists’ Migration Readiness within the PPM framework. Because the instrument was author-developed or conceptually adapted from previous literature, measurement evaluation and refinement and structural-model testing were conducted within the same convenience sample, and the convergent validity of the formative composites was not established through redundancy analysis, the results require independent replication. The model should not be regarded as a validated workforce-monitoring, individual-prediction, or decision-support instrument.

Background/Objectives: The potential migration of future pharmacists can affect healthcare systems’ ability to maintain a sufficient, stable, and adequately distributed workforce, with implications for the continuity of pharmaceutical services and the safe use of medicines. This study examines Migration Readiness (MR) among pharmacy students in Romania as a candidate aggregate indicator of future workforce-retention vulnerability and identifies the associated professional, economic, social, and structural factors. Methods: A quantitative, cross-sectional, and observational design was employed, based on 520 valid questionnaires. An extended Push–Pull–Mooring model was developed and tested, incorporating internal professional pressures (PUSH), professional prospects in Romania (DPO), the professional-economic appeal of external opportunities (PEP), the appeal associated with quality of life (QLP), personal and social barriers (PB), structural barriers (SB), and Migration Readiness (MR). The model was estimated using PLS-SEM in SmartPLS 4. The significance of relationships was assessed via bootstrapping with 10,000 subsamples, while predictive performance was evaluated using PLSpredict and CVPAT. Results: The model explains 39.2% of the variance in MR and demonstrates a good approximate fit (estimated SRMR = 0.038). PUSH is negatively associated with DPO (β = −0.387) and positively associated with PEP (β = 0.413) and QLP (β = 0.173). PEP is strongly associated with QLP (β = 0.523), while PEP and QLP are positively associated with MR (β = 0.272 and β = 0.221, respectively). DPO, PB and SB are negatively associated with MR (β = −0.128, β = −0.187 and β = −0.175, respectively). Significant specific indirect associations indicate that part of the association between professional pressures and MR operates through the assessment of domestic career prospects and external opportunities. Conclusions: Pharmacy students’ migration readiness reflects a multidimensional process in which internal professional conditions, the attractiveness of external opportunities, and mobility barriers act simultaneously. At an aggregate level, MR may represent a candidate perceptual indicator of future workforce-retention vulnerability; however, longitudinal validation against actual post-graduation employment and migration outcomes is required before operational workforce use. The results suggest that pharmaceutical workforce planning should combine measures addressing career prospects, working conditions, professional development, and quality of life, rather than focusing solely on remuneration.