Silica nanoparticles (SiO₂ NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO₂ NPs surfaces. The DOX·HCl loading onto and release from the SiO₂ NPs was monitored via UV-VIS and fluorescence spectra. Alternatively, the zeta potential was also used to monitor and evaluate the DOX·HCl loading process. The results showed that nearly 98% of DOX·HCl was effectively loaded onto the SiO₂ NPs’ surfaces by electrostatic interaction. The pH-dependence of the process wherein DOX·HCl release out of DOX·HCl-SiO₂ NPs was investigated as well. For comparison, both the free DOX·HCl molecules and DOX·HCl-SiO₂ NPs were used as the labels for cultured cancer cells. Confocal laser scanning microscopy images showed that the DOX·HCl-SiO₂ NPs were better delivered to cancer cells which are more acidic than healthy cells. We propose that engineered DOX·HCl-SiO₂ systems are good candidates for drug delivery and clinical applications.

Neutrino oscillations are genuine quantum phenomena in which coherent oscillations are maintained over a long distance. As a result, in principle, the phenomena can be studied efficiently using quantum simulations. In today’s noisy quantum hardware, encoding neutrinos in a multiqubit system requires a redundant basis and tricky entangling gates. We encode a three-flavor neutrino in a superconducting qutrit and study its oscillations using Pontecorvo-Maki-Nakagawa-Sakata theory with time evolution expressed in terms of single qutrit gates. The qutrit is engineered from the multilevel structure of IBM transmon devices. High-fidelity gate control and readout are fine-tuned using programming microwave pulses using a high-level language. Our quantum simulations on real hardware match the analytical calculations well in three oscillation cases: vacuum, interaction with matter, and $CP$ violation.