Background/Objectives: Non-communicable diseases (NCDs) are strongly linked to beverage consumption. This study aimed to assess the average daily beverage intake of Saudi residents, energy intake from beverages, and the influence of socio-demographic factors, health behaviors, and health status on beverage intake. Methods: A nationally representative, cross-sectional study utilized stratified quota sampling to survey adults (≥18 years) across all 13 administrative regions of Saudi Arabia. Data were collected from April 2022 to December 2023 using the validated Arabic Beverage Frequency Questionnaire (ABFQ), assessing consumption patterns of 28 beverage types. Results: The study included 4385 participants (mean age: 36.1 ± 11.14 years, 65% male). Sweetened tea (28 mL/day), regular soft drinks (22.1 mL/day), and Saudi coffee (18 mL/day) were the most frequent beverages after water. Sweetened tea contributed to the highest average energy intake (33.2 ± 46.4 kcal/day). Consumption of sugar-sweetened beverages (SSBs) was higher among younger individuals (18–29 years: OR: 4.0, 95% CI [2.6–6.3]; 30–44 years: OR: 2.8, 95% CI [1.8–4.3]), males (OR:1.6, 95% CI [1.4–1.8]), and residents of specific regions [Al-Jawf (OR: 1.9, 95% CI [1.2–3.2]) and Jazan (OR: 3.2, 95% CI [2.2–4.7])]. Higher water intakes were associated with males (OR: 1.5, 95% CI [1.3–1.7]), higher education levels (OR: 1.4, 95% CI [1.2–1.8]), physically active (OR: 1.5, 95% CI [1.3–1.8]), and those overweight (OR: 1.6, 95% CI [1.2–2.3]) or obese (OR: 2, 95% CI [1.4–2.8]). Conclusions: This study provides a valuable insight into beverage consumption patterns among Saudi residents. The findings highlight the need for targeted public health interventions to promote healthier beverage choices, particularly among younger populations and those with lower socioeconomic status.

Hydrazono­[1,3,4]­thiadiazoles have a prominent position among the heterocyclic compounds due to their broadening aspects of biological activities. In the current study, a neoteric series of [1,3,4]­thiadiazoles tethered to alkoxyaryl hydrazone has been formulated via the treatment of methyl 2-[3-(pentyloxy)­benzylidene]­hydrazine-1-carbodithioate and hydrazonoyl chlorides in ethanolic solution under thermal conditions. DABCO, as an environmentally nontoxic material, was utilized as a superior basic catalyst for the latter reaction. The structures of the isolated products were explicated by spectral (IR, NMR, and MS) and elemental analysis tools. The antitumor activity of the synthesized products was assessed against the breast cancer MCF-7 cell line. The results displayed that compounds 5a and 5f have highly selective inhibition profiles related to doxorubicin as a reference drug. The molecular docking analysis was performed using the Molecular Operating Environment (MOE) software through the interaction with the VEGFR-2 protein (PDB: 2OH4) and revealed that compounds 5a and 5f are linked with the same amino acid (GLU883), similar to the reference antibiotic doxorubicin. Also, these compounds exhibited higher binding affinities (−7.86 and −8.47 kcal/mol, respectively) than the reference compound (−6.68 kcal/mol), which supported their antitumor efficacy against the MCF-7 cell line. Moreover, confirmation of the drug-like properties and toxicity predictions of the newly synthesized compounds (5a–m) was achieved via in silico ADME.