Rodrigo Isaias Lopes Pereira

Mr. Rodrigo Isaias Lopes Pereira

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Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 July 2025 in Biomedicines
Verified
Journal Article
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Glauco Rodrigues Carmo SilveiraGlauco Rodrigues Carmo Silveira
Glauco Rodrigues Carmo Silveira
VGVinícius Franzão Ganzaroli
Vinícius Franzão Ganzaroli
LTLuan Felipe Toro
Luan Felipe Toro
LCLeandro Lemes da Costa
Leandro Lemes da Costa
Rodrigo Isaias Lopes PereiraRodrigo Isaias Lopes Pereira
Rodrigo Isaias Lopes Pereira
Edilson ErvolinoEdilson Ervolino
Edilson Ervolino
Objective: This study aimed to evaluate the effects of local use of Brazilian Green Propolis (BGP), either as an ethanolic extract (the most common formulation) or incorporated into lipid-based nanostructures, as an adjuvant therapy for non-surgical periodontal treatment in managing experimental periodontitis (EP) in ovariectomized rats. Methods: Fifty-six female Wistar rats underwent bilateral ovariectomies. After 10 weeks, a cotton ligature was placed around the lower first molar and remained in place for two weeks to induce EP. The ligature was removed, and the rats were randomly assigned in the groups NLT (n = 14), SRP (n = 14), SRP-BGPee (n = 14), and SRP-BGPlns (n = 14). In the NLT group, no local treatment was performed. The SRP group received scaling and root planing (SRP), along with irrigation using a physiological saline solution. The SRP-BGPee group underwent SRP and irrigation with ethanolic extract of BGP. The SRP-BGPlns group underwent SRP and irrigation with BGP-loaded lipid nanostructure (BGPlns). Each group received one SRP session followed by four irrigation sessions with the specified solutions, which were conducted immediately after SRP and subsequently after 2, 4, and 6 days. Euthanasia was performed at 7 and 28 days following the removal of the ligatures. The hemimandibles were processed for the following analyses: microtomographic analysis; histological analysis; histometric analysis of the percentage of bone tissue in the furcation region (PBT); and immunohistochemical analysis for tartrate-resistant acid phosphatase activity (TRAP), transforming growth factor beta 1 (TGFβ1), and osteocalcin (OCN). Results: The SRP-BGPlns group demonstrated superior periodontal tissue repair, reduced alveolar bone loss, fewer TRAP-positive cells (at 7 days), and higher levels of immunolabeling for TGFβ1 (at both 7 and 28 days) and OCN (at 28 days) compared to the other experimental groups. Conclusions: The irrigation with BGP is an effective adjuvant therapy for non-surgical periodontal treatment in managing EP in ovariectomized rats. Its application in lipid-based nanostructures proved to be more effective than the ethanolic extract form.

1 August 2024 in Research, Society and Development
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EPEstêvão Lopes Pereira
Estêvão Lopes Pereira
ISIsadora Castaldi Sousa
Isadora Castaldi Sousa
Rodrigo Isaias Lopes PereiraRodrigo Isaias Lopes Pereira
Rodrigo Isaias Lopes Pereira
LCLeandro Lemes da Costa
Leandro Lemes da Costa
JAJoyce Sayuri Akazaki
Joyce Sayuri Akazaki
PBPaulo Roberto Botacin
Paulo Roberto Botacin
As Ligas Acadêmicas (L.A.) são grupos de estudantes que buscam aprofundar seus conhecimentos em temas específicos, atendendo às necessidades da comunidade, sob a orientação de um docente escolhido pelos discentes. Sem fins lucrativos, essas ligas promovem o ensino, a pesquisa e a extensão. A Liga Acadêmica de Anatomia Orofacial (LAAO) foi criada para integrar a anatomia com a harmonização orofacial (HOF) e a odontologia forense, áreas pouco exploradas na graduação. Este estudo busca identificar se a L.A. contribui positivamente para a formação acadêmica e pessoal dos discentes e beneficia toda a comunidade acadêmica. Foi realizada uma pesquisa exploratória, com abordagens quantitativa e qualitativa. A amostra, não probabilística, foi composta por alunos voluntários, membros internos da LAAO, do 2º ao 12º semestre do curso de Odontologia, exceto aqueles envolvidos na elaboração deste artigo. A coleta de dados ocorreu por meio de um questionário aplicado via "Google Forms". A análise dos resultados destaca a importância das ligas acadêmicas na complementação da formação, promovendo a integração entre teoria e prática. Elas oferecem benefícios tanto para os estudantes quanto para a comunidade acadêmica, além de aprofundar conhecimentos essenciais para cursos da área da saúde e promover um currículo diferenciado. O estudo confirma que as Ligas Acadêmicas são fundamentais para a formação dos graduandos, proporciona benefícios significativos para o desenvolvimento acadêmico e pessoal. Os alunos reconhecem seu valor e impacto positivo na comunidade acadêmica, aprimora o aprendizado e incentiva a integração.

30 July 2025 in ARCHIVES OF HEALTH INVESTIGATION
Verified
Journal Article
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VGVinícius Franzão Ganzaroli
Vinícius Franzão Ganzaroli
JMJuliana de Aguiar Silveira Meira
Juliana de Aguiar Silveira Meira
ABAna Carolina Zucon Bacelar
Ana Carolina Zucon Bacelar
Laura Vidoto PaludettoLaura Vidoto Paludetto
Laura Vidoto Paludetto
Rodrigo Isaias Lopes PereiraRodrigo Isaias Lopes Pereira
Rodrigo Isaias Lopes Pereira
DPDaniela Ponzoni
Daniela Ponzoni
To report the surgical management of a dentigerous cyst associated with a transmigrated mandibular canine using resective and regenerative techniques. A 28-year-old male presented with mandibular swelling, numbness, and pain. Imaging revealed a bone lesion associated with an impacted, transmigrated canine. Treatment included cyst decompression, enucleation, and guided bone regeneration (GBR) using biomaterials and a collagen membrane. Follow-up evaluations were conducted at 3, 6, and 12 months. Histopathology confirmed a dentigerous cyst. Post-operative healing was successful, with no recurrence, pain, or paresthesia. Radiographic evaluations showed significant bone repair and no signs of lesion recurrence. The combination of decompression, enucleation, and GBR effectively treated this rare case, minimizing bone defects and ensuring favorable outcomes. This approach is recommended for similar cases.

18 December 2025 in ARCHIVES OF HEALTH INVESTIGATION
Verified
Journal Article
Closed access
Glauco Rodrigues Carmo SilveiraGlauco Rodrigues Carmo Silveira
Glauco Rodrigues Carmo Silveira
VGVinícius Franzão Ganzaroli
Vinícius Franzão Ganzaroli
Rodrigo Isaias Lopes PereiraRodrigo Isaias Lopes Pereira
Rodrigo Isaias Lopes Pereira
LCLeandro Lemes da Costa
Leandro Lemes da Costa
ARArthur Nascimento Rocha
Arthur Nascimento Rocha
EEEdilson Ervolino
Edilson Ervolino
The nasopalatine duct cyst (NPDC) is classified as a non-odontogenic cyst of the oral cavity, whose pathogenesis is not yet fully understood. Clinically, the patient may present with swelling in the anterior region of the maxilla and palatal mucosa or elevation of the upper lip; however, in many cases, the lesion is asymptomatic, and the adjacent teeth remain vital. The treatment of choice consists of complete enucleation of the lesion associated with curettage, especially when the cyst is not large. The aim of this study is to report a clinical case of NPDC treated surgically, in which complete enucleation was performed after a clinical and tomographic diagnosis compatible with the lesion. The case involves a 30-year-old male patient with no systemic comorbidities who reported pain and slight edema in the anterior region of the palate. During the clinical examination, a fluctuating mass was observed on palpation near the incisive papilla. The teeth adjacent to the lesion showed preserved pulp vitality. The tomographic examination showed a well-defined hypodense image in the nasopalatine duct region, associated with bone fenestration, corroborating the suspected diagnosis. Given these findings, surgical intervention was performed for complete enucleation and subsequent histopathological analysis, which confirmed the diagnosis of NPDC. The patient progressed favorably, receiving appropriate postoperative care and clinical follow-up. It is concluded that, for the present clinical case, surgical enucleation of the NPDC proved to be an effective treatment, avoiding further complications for the patient.

18 December 2025 in ARCHIVES OF HEALTH INVESTIGATION
Verified
Journal Article
Closed access
Rodrigo Isaias Lopes PereiraRodrigo Isaias Lopes Pereira
Rodrigo Isaias Lopes Pereira
Gabriela Carrara SimionatoGabriela Carrara Simionato
Gabriela Carrara Simionato
EPEstêvão Lopes Pereira
Estêvão Lopes Pereira
CSCristiano Gama da Silva
Cristiano Gama da Silva
EEEdilson Ervolino
Edilson Ervolino
LTLeticia Helena Theodoro
Leticia Helena Theodoro
Hypertrophic labial frenulum is characterized by the permanence of gingival fibers connected to the incisive papilla or maintained in a low attachment, which may lead to the development of na interincisive diastema. In most cases, this condition representes an aesthetic and/or functional concern for the patient. This manuscript aims to present a case report of diastema closure using direct restorative techniques after upper labial frenectomy with a high-power laser, followed by photobiomodulation. A 42-year-old female patient complained of the space between her upper central incisors and reported having undergone orthodontic treatment twice. After a thorough medical history and clinical examination, it was decided to perform a labial frenectomy with a high-power diode laser (808 nm, 1.5 W, 20 Hz) to correct the hypertrophic labial frenulum. followed by low-power laser (660 nm, 6 J, 100 mW, 60 seconds) for photobiomodulation, with the aim of reducing trans and postoperative pain. Weeks after the procedure, with the surgical area completely healed, the diastema was closed using composite resins. It can be concluded that an excellent functional and aesthetic result was achieved, exceeding the patient's expectations, with an improvement in her self-esteem and social interaction.

25 May 2026 in ARCHIVES OF HEALTH INVESTIGATION
Verified
Journal Article
Closed access
VGVinícius Franzão Ganzaroli
Vinícius Franzão Ganzaroli
Rodrigo Isaias Lopes PereiraRodrigo Isaias Lopes Pereira
Rodrigo Isaias Lopes Pereira
AVArthur Henrique Alécio Viotto
Arthur Henrique Alécio Viotto
AMAna Paula Ribeiro Miranda
Ana Paula Ribeiro Miranda
MFMilena Forin
Milena Forin
IJIdelmo Rangel Garcia Júnior
Idelmo Rangel Garcia Júnior
Mandibular fractures are among the most common injuries in maxillofacial trauma, generally associated with high-energy accidents, such as motorcycle accidents. Due to its anatomical position and mobility, the mandible is particularly susceptible to direct impacts. The diagnosis of these fractures is based on clinical evaluation combined with imaging studies, with computed tomography (CT) being the gold standard. Treatment varies according to the complexity of the case, with open reduction and internal fixation being widely used because it provides stability and early functional recovery. The aim of this study is to report on a clinical case of a right mandibular angle fracture resulting from a motorcycle accident. A 25-year-old male patient presented with pain, limited mouth opening, edema, and malocclusion. A CT scan confirmed the diagnosis. The surgical procedure was performed under general anesthesia, with reduction and internal fixation of the fracture using two 2.0-system titanium plates and screws, combined with intraoperative maxillomandibular block. The postoperative course was satisfactory, without complications, with progressive improvement in mandibular function. It is concluded that the surgical approach employed proved effective, promoting adequate bone stability and functional recovery, reinforcing its indication for mandibular fractures with displacement.