Dental rehabilitation with titanium implants may requires the optimization of techniques and materials when oral conditions affect the successful treatment result. Thus, this study aims to customize the surface of titanium implants with bioactive vitamin D3 molecules to increase the performance of bone repair. The surfaces were functionalized following the “dip-coating” incorporation method with vitamin D3 in a solution of 1000 I.U./goat. The work was carried out in two stages: (I) physicochemical and biological tests (in vivo) in order to characterize and validate the vitamin D3 surface as well as its ability to affect peri-implant bone biomechanics; and (II) in vitro experiments to characterize viability responses, interaction and cell mineralization capacity. Scanning electron microscopy showed that the creation of vitamin D3 films is stable and homogeneous, while the in vivo results showed an increase in the biomechanical and microarchitectural capacity of the bone when vitamin D3 implants were used. Furthermore, the application of functionalized surfaces proved effective in promoting cell interaction and bone mineralization processes while preserving cell viability and capacity. In conclusion, the delivery of bioactive molecules based on vitamin D3 promotes changes in the surface microstructure of titanium, enabling an increase in the structural characteristics of bone tissue that result in an improvement in bone repair and peri-implant biomechanics.

The use of herbal medicines has gained popularity, both in science and among the public, as a natural alternative for the treatment of numerous diseases, including type 2 diabetes. Objective: The objective of this study was to evaluate peri-implant and long bone biomechanics in type 2 diabetic animals, treated or not with Bauhinia forficata. Methods: Thirty-two rats were allocated into four groups: normoglycemic (NG), normoglycemic + Bauhinia forficata (NGBf), type 2 diabetes (T2D), and T2D + Bauhinia forficata (T2DBf). Diabetes was induced using a cafeteria diet and streptozotocin (35 mg/kg). Bauhinia forficata tea (50 g/L) was administered to the NGBf and T2DBf groups. After 14 days, titanium implants were installed in the tibial metaphysis of all animals. Biomechanical analysis (removal torque), computerized microtomography, three-point bending test, confocal microscopy, and real-time PCR were performed. The results were tabulated, and a statistical test was conducted with a significance level of 5%. Results: Bauhinia forficata significantly improved the weight and blood glucose levels of the animals. In terms of biomechanics and the microarchitecture of long bones, T2D did not impair bone metabolism, and the use of the therapy did not cause significant changes in the parameters evaluated. However, T2D promoted significant impairment in the structural, biomechanical, and molecular characteristics of the peri-implant repair process, and the use of Bauhinia forficata increased the parameters evaluated in T2DBf. Conclusions: Type 2 diabetes mellitus significantly compromises peri-implant bone repair, with no influence on the metabolism of long bones, and Bauhinia forficata acts positively on both the etiopathogenesis of the disease and the tissue response to bone repair.

As Ligas Acadêmicas (L.A.) são grupos de estudantes que buscam aprofundar seus conhecimentos em temas específicos, atendendo às necessidades da comunidade, sob a orientação de um docente escolhido pelos discentes. Sem fins lucrativos, essas ligas promovem o ensino, a pesquisa e a extensão. A Liga Acadêmica de Anatomia Orofacial (LAAO) foi criada para integrar a anatomia com a harmonização orofacial (HOF) e a odontologia forense, áreas pouco exploradas na graduação. Este estudo busca identificar se a L.A. contribui positivamente para a formação acadêmica e pessoal dos discentes e beneficia toda a comunidade acadêmica. Foi realizada uma pesquisa exploratória, com abordagens quantitativa e qualitativa. A amostra, não probabilística, foi composta por alunos voluntários, membros internos da LAAO, do 2º ao 12º semestre do curso de Odontologia, exceto aqueles envolvidos na elaboração deste artigo. A coleta de dados ocorreu por meio de um questionário aplicado via "Google Forms". A análise dos resultados destaca a importância das ligas acadêmicas na complementação da formação, promovendo a integração entre teoria e prática. Elas oferecem benefícios tanto para os estudantes quanto para a comunidade acadêmica, além de aprofundar conhecimentos essenciais para cursos da área da saúde e promover um currículo diferenciado. O estudo confirma que as Ligas Acadêmicas são fundamentais para a formação dos graduandos, proporciona benefícios significativos para o desenvolvimento acadêmico e pessoal. Os alunos reconhecem seu valor e impacto positivo na comunidade acadêmica, aprimora o aprendizado e incentiva a integração.

Objetivo: personalizar a superfície de implantes de titânio com moléculas bioativas de vitamina D3 para aumentar o desempenho do reparo ósseo periimplantar. Material e Métodos: o trabalho foi realizado em duas etapas: (I) testes físico-químicos e biológicos (in vivo) para caracterizar e validar a superfície com vitamina D3, bem como sua capacidade de afetar a biomecânica óssea peri-implantar; e (II) experimentos in vitro para caracterizar as respostas de viabilidade, interação e capacidade de mineralização celular. Resultados: a microscopia eletrônica de varredura mostrou que a criação de películas de vitamina D3 é estável e homogênea, enquanto os resultados in vivo mostraram um aumento da capacidade biomecânica e da microarquitetura óssea quando foram utilizados implantes com vitamina D3. Além disso, a aplicação de superfícies funcionalizadas revelou-se eficaz na promoção da interação celular e dos processos de mineralização óssea, preservando a viabilidade e a capacidade das células. Conclusão: a entrega de moléculas bioativas à base de vitamina D3 promove alterações na microestrutura da superfície do titânio, permitindo um aumento das características estruturais do tecido ósseo, que resultam em uma melhoria da reparação óssea e da biomecânica peri-implantar. Palavras-chave: Implantes Dentais; Sistemas de Liberação de Medicamentos; Vitamina D; Colecalciferol; Modelos Animais.

Immediate implant placement combined with immediate provisionalization may preserve peri-implant tissue contours and reduce the esthetic impact of the healing period. This case report describes the rehabilitation of tooth 21 in a systemically healthy 36-year-old man with a vertical root fracture after trauma and endodontic treatment. Minimally traumatic extraction was performed, followed by immediate implant placement in a palatal position with an insertion torque of 40 Ncm and filling of the buccal gap with a xenogeneic biomaterial. The extracted clinical crown was separated from the root, converted into a veneer, and bonded to a provisional titanium cylinder with flowable composite resin, allowing fabrication of a screw-retained provisional restoration. The emergence profile was adjusted to support the soft tissues, and sutures were unnecessary. At 90 days, uneventful healing, a favorable peri-implant contour, and maintenance of the gingival architecture were observed. Within the limitations of the short follow-up, the technique proved to be a conservative and esthetic alternative for selected cases in the anterior maxilla.

This study investigated the synergistic effects of resveratrol and antimicrobial photodynamic therapy (aPDT) on peri‐implant bone repair in a type 2 diabetes model. Forty‐eight rats were allocated into four groups: normoglycemic, normoglycemic + resveratrol, type 2 diabetes (T2D), and T2D + resveratrol. Diabetes was induced using a cafeteria diet and streptozotocin (35 mg/kg). Resveratrol (100 mg/kg) was administered systemically beginning 7 days later. After 14 days, maxillary molars were extracted, and surgical drilling was performed. Half of the animals in each group received aPDT (methylene blue and 660 nm diode laser) before immediate implant placement. Animals were euthanized 28 days post‐surgery for biomechanical, RT‐PCR, and confocal microscopy analyses. Resveratrol improved glycemic control and body weight. In T2D animals, aPDT significantly enhanced implant removal torque. Gene expression analyses revealed downregulation of bone resorption markers and upregulation of bone mineralization genes in T2D and T2D + resveratrol groups treated with aPDT. Confocal microscopy demonstrated increased mineral apposition rates in animals treated with resveratrol and/or aPDT. These findings suggest that the combination of systemic resveratrol and local aPDT enhances peri‐implant bone healing under diabetic conditions, highlighting a potential therapeutic approach to improve implant osseointegration in compromised metabolic states.